Natural graphs, such as social networks, email graphs, or instant messaging patterns, have become pervasive through the internet. These graphs are massive, often containing hundreds of millions of nodes and billions of edges. While some theoretical models have been proposed to study such graphs, their analysis is still difficult due to the scale and nature of the data.

Material and methods For a large-scale dataset of over 200,000 SNPs from about 200 individuals together with several phenotypes, published by Atwell et al. [1], we develop efficient methods to find pairs of SNPs which are strongly associated with the phenotype. As an exhaustive search of all possible combinations of interacting SNPs is often unfeasible, even when only considering pairs of interacting SNPs, the challenge is to find methods which avoid an exhaustive search but can still guarantee to find the causal pair. We propose two distinct approaches to efficiently determine the t top-scoring pairs of SNPs.

This letter presents a graph kernel for spatio-spectral remote sensing image classification with support vector machines (SVMs). The method considers higher order relations in the neighborhood (beyond pairwise spatial relations) to iteratively compute a kernel matrix for SVM learning. The proposed kernel is easy to compute and constitutes a powerful alternative to existing approaches. The capabilities of the method are illustrated in several multi- and hyperspectral remote sensing images acquired over both urban and agricultural areas.

Current graph kernels suffer from two limitations: graph kernels based on counting particular types of subgraphs ignore the relative position of these subgraphs to each other, while graph kernels based on algebraic methods are limited to graphs without node labels. In this paper we present the graphlet spectrum, a system of graph invariants derived by means of group representation theory that capture information about the number as well as the position of labeled subgraphs in a given graph. In our experimental evaluation the graphlet spectrum outperforms state-of-the-art graph kernels.

In this article, we propose fast subtree kernels on graphs. On graphs with n nodes and m edges and maximum degree d, these kernels comparing subtrees of height h can be computed in O(mh), whereas the classic subtree kernel by Ramon & G¨artner scales as O(n24dh). Key to this efficiency is the observation that the Weisfeiler-Lehman test of isomorphism from graph theory elegantly computes a subtree kernel as a byproduct. Our fast subtree kernels can deal with labeled graphs, scale up easily to large graphs and outperform state-of-the-art graph ker- nels on several classification benchmark datasets in terms of accuracy and runtime.