Industrial Anomaly Detection (IAD) is critical for ensuring product quality by identifying defects. Traditional methods such as feature embedding and reconstruction-based approaches require large datasets and struggle with scalability. Existing vision-language models (VLMs) and Multimodal Large Language Models (MLLMs) address some limitations but rely on mask annotations, leading to high implementation costs and false positives. Additionally, industrial datasets like MVTec-AD and VisA suffer from severe class imbalance, with defect samples constituting only 23.8 % and 11.1 % of total data respectively. To address these challenges, we propose a reward function that dynamically prioritizes rare defect patterns during training to handle class imbalance. We also introduce a mask-free reasoning framework using Chain of Thought (CoT) and Group Relative Policy Optimization (GRPO) mechanisms, enabling anomaly detection directly from raw images without annotated masks. This approach generates interpretable step-by-step explanations for defect localization. Our method achieves state-of-the-art performance, outperforming prior approaches by 36% in accuracy on MVTec-AD and 16% on VisA. By eliminating mask dependency and reducing costs while providing explainable outputs, this work advances industrial anomaly detection and supports scalable quality control in manufacturing.

Process synchronization primitives lubricate server computing involving a group of processes as they ensure those processes to properly coordinate their executions for a common purpose such as provisioning a web service. A malfunctioned synchronization due to attacks causes friction among processes and leads to unexpected, and often hard-to-detect, application transaction errors. Unfortunately, synchronization primitives are not naturally protected by existing hardware-assisted isolation techniques e.g., SGX, because their process-oriented isolation conflicts with the primitive's demand for cross-process operations.

Frauds in supply chain finance not only result in substantial loss for financial institutions (e.g., banks, trust company, private funds), but also are detrimental to the reputation of the ecosystem. However, such frauds are hard to detect due to the complexity of the operating environment in supply chain finance such as involvement of multiple parties under different agreements. Traditional instruments of financial institutions are time-consuming yet insufficient in countering fraudulent supply chain financing. In this study, we propose a novel blockchain-driven framework for deterring fraud in supply chain finance. Specifically, we use inventory financing in jewelry supply chain as an illustrative scenario. The blockchain technology enables secure and trusted data sharing among multiple parties due to its characteristics of immutability and traceability. Consequently, information on manufacturing, brand license, and warehouse status are available to financial institutions in real time. Moreover, we develop a novel rule-based fraud check module to automatically detect suspicious fraud cases by auditing documents shared by multiple parties through a blockchain network. To validate the effectiveness of the proposed framework, we employ agent-based modeling and simulation. Experimental results show that our proposed framework can effectively deter fraudulent supply chain financing as well as improve operational efficiency.

To understand whether any human-specific new genes may be associated with human brain functions, we computationally screened the genetic vulnerable factors identified through Genome-Wide Association Studies and linkage analyses of nicotine addiction and found one human-specific de novo protein-coding gene, FLJ33706 (alternative gene symbol C20orf203). Cross-species analysis revealed interesting evolutionary paths of how this gene had originated from noncoding DNA sequences: insertion of repeat elements especially Alu contributed to the formation of the first coding exon and six standard splice junctions on the branch leading to humans and chimpanzees, and two subsequent substitutions in the human lineage escaped two stop codons and created an open reading frame of 194 amino acids. We experimentally verified FLJ33706's mRNA and protein expression in the brain. Real-Time PCR in multiple tissues demonstrated that FLJ33706 was most abundantly expressed in brain. Human polymorphism data suggested that FLJ33706 encodes a protein under purifying selection. A specifically designed antibody detected its protein expression across human cortex, cerebellum and midbrain. Immunohistochemistry study in normal human brain cortex revealed the localization of FLJ33706 protein in neurons. Elevated expressions of FLJ33706 were detected in Alzheimer's brain samples, suggesting the role of this novel gene in human-specific pathogenesis of Alzheimer's disease. FLJ33706 provided the strongest evidence so far that human-specific de novo genes can have protein-coding potential and differential protein expression, and be involved in human brain functions.