Homomorphic encryption enables computation on encrypted data while maintaining secrecy. This leads to an important open question whether quantum computation can be delegated and verified in a non-interactive manner or not. In this paper, we affirmatively answer this question by constructing the quantum homomorphic encryption scheme with quantum obfuscation. It takes advantage of the interchangeability of the unitary operator, and exchanges the evaluation operator and the encryption operator by means of equivalent multiplication to complete homomorphic encryption. The correctness of the proposed scheme is proved theoretically. The evaluator does not know the decryption key and does not require a regular interaction with a user. Because of key transmission after quantum obfuscation, the encrypting party and the decrypting party can be different users. The output state has the property of complete mixture, which guarantees the scheme security. Moreover, the security level of the quantum homomorphic encryption scheme depends on quantum obfuscation and encryption operators.