Nucleus instance segmentation from histopathology images suffers from the extremely laborious and expert-dependent annotation of nucleus instances. As a promising solution to this task, annotation-efficient deep learning paradigms have recently attracted much research interest, such as weakly-/semi-supervised learning, generative adversarial learning, etc. In this paper, we propose to formulate annotation-efficient nucleus instance segmentation from the perspective of few-shot learning (FSL). Our work was motivated by that, with the prosperity of computational pathology, an increasing number of fully-annotated datasets are publicly accessible, and we hope to leverage these external datasets to assist nucleus instance segmentation on the target dataset which only has very limited annotation. To achieve this goal, we adopt the meta-learning based FSL paradigm, which however has to be tailored in two substantial aspects before adapting to our task. First, since the novel classes may be inconsistent with those of the external dataset, we extend the basic definition of few-shot instance segmentation (FSIS) to generalized few-shot instance segmentation (GFSIS). Second, to cope with the intrinsic challenges of nucleus segmentation, including touching between adjacent cells, cellular heterogeneity, etc., we further introduce a structural guidance mechanism into the GFSIS network, finally leading to a unified Structurally-Guided Generalized Few-Shot Instance Segmentation (SGFSIS) framework. Extensive experiments on a couple of publicly accessible datasets demonstrate that, SGFSIS can outperform other annotation-efficient learning baselines, including semi-supervised learning, simple transfer learning, etc., with comparable performance to fully supervised learning with around 10% annotations.

Histopathological tissue classification is a simpler way to achieve semantic segmentation for the whole slide images, which can alleviate the requirement of pixel-level dense annotations. Existing works mostly leverage the popular CNN classification backbones in computer vision to achieve histopathological tissue classification. In this paper, we propose a super lightweight plug-and-play module, named Pyramidal Deep-Broad Learning (PDBL), for any well-trained classification backbone to improve the classification performance without a re-training burden. For each patch, we construct a multi-resolution image pyramid to obtain the pyramidal contextual information. For each level in the pyramid, we extract the multi-scale deep-broad features by our proposed Deep-Broad block (DB-block). We equip PDBL in three popular classification backbones, ShuffLeNetV2, EfficientNetb0, and ResNet50 to evaluate the effectiveness and efficiency of our proposed module on two datasets (Kather Multiclass Dataset and the LC25000 Dataset). Experimental results demonstrate the proposed PDBL can steadily improve the tissue-level classification performance for any CNN backbones, especially for the lightweight models when given a small among of training samples (less than 10%). It greatly saves the computational resources and annotation efforts. The source code is available at: https://github.com/linjiatai/PDBL.

Cyber-physical systems (CPS) including power systems, transportation, industrial control systems, etc. support both advanced control and communications among system components. Frequent data operations could introduce random failures and malicious attacks or even bring down the whole system. The dependency on a central authority increases the risk of single point of failure. To establish an immutable data provenance scheme for CPS, the authors adopt blockchain and propose a decentralized architecture to assure data integrity. In business-driven CPS, end users are required to share their personal information with multiple third parties. To prevent data leakage and preserve user privacy, the authors isolate and feed different information retrieval requests using tokens specifically generated for each type of request. Providing both traceability of data operations, and unlinkability of end user activities, a robust blockchain-based CPS is prototyped. Evaluation indicates the architecture is capable of assured data provenance validation and user privacy preservation at a low overhead.

DeepMatching (DM) is one of the state-of-art matching algorithms to compute quasi-dense correspondences between images. Recent optical flow methods use DeepMatching to find initial image correspondences and achieves outstanding performance. However, the key building block of DeepMatching, the correlation map computation, is time-consuming. In this paper, we propose a new algorithm, LSHDM, which addresses the problem by employing Locality Sensitive Hashing (LSH) to DeepMatching. The computational complexity is greatly reduced for the correlation map computation step. Experiments show that image matching can be accelerated by our approach in ten times or more compared to DeepMatching, while retaining comparable accuracy for optical flow estimation.

Enabled by mobile and wearable technology, personal health data delivers immense and increasing value for healthcare, benefiting both care providers and medical research. The secure and convenient sharing of personal health data is crucial to the improvement of the interaction and collaboration of the healthcare industry. Faced with the potential privacy issues and vulnerabilities existing in current personal health data storage and sharing systems, as well as the concept of self-sovereign data ownership, we propose an innovative user-centric health data sharing solution by utilizing a decentralized and permissioned blockchain to protect privacy using channel formation scheme and enhance the identity management using the membership service supported by the blockchain. A mobile application is deployed to collect health data from personal wearable devices, manual input, and medical devices, and synchronize data to the cloud for data sharing with healthcare providers and health insurance companies. To preserve the integrity of health data, within each record, a proof of integrity and validation is permanently retrievable from cloud database and is anchored to the blockchain network. Moreover, for scalable and performance considerations, we adopt a tree-based data processing and batching method to handle large data sets of personal health data collected and uploaded by the mobile platform.