Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due to the fundamental imbalance where a single bag-level label must guide the learning of numerous patch-level features. This sparse supervision makes it difficult to reliably identify discriminative patches during training, leading to unstable optimization and suboptimal solutions. We propose a spatially regularized MIL framework that leverages inherent spatial relationships among patch features as label-independent regularization signals. Our approach learns a shared representation space by jointly optimizing feature-induced spatial reconstruction and label-guided classification objectives, enforcing consistency between intrinsic structural patterns and supervisory signals. Experimental results on multiple public datasets demonstrate significant improvements over state-of-the-art methods, offering a promising direction. The code is available at https://github.com/wwyi1828/SRMIL.

Visual Question Answering (VQA) is increasingly used in diverse applications ranging from general visual reasoning to safety-critical domains such as medical imaging and autonomous systems, where models must provide not only accurate answers but also explanations that humans can easily understand and verify.Prototype-based modeling has shown promise for interpretability by grounding predictions in semantically meaningful regions for purely visual reasoning tasks, yet remains underexplored in the context of VQA.We present ProtoVQA, a unified prototypical framework that (i) learns question-aware prototypes that serve as reasoning anchors, connecting answers to discriminative image regions, (ii) applies spatially constrained matching to ensure that the selected evidence is coherent and semantically relevant, and (iii) supports both answering and grounding tasks through a shared prototype backbone.To assess explanation quality, we propose the Visual-Linguistic Alignment Score (VLAS), which measures how well the model's attended regions align with ground-truth evidence.Experiments on Visual7W show that ProtoVQA yields faithful, fine-grained explanations while maintaining competitive accuracy, advancing the development of transparent and trustworthy VQA systems.

Xingjian Diao, Chunhui Zhang, Keyi Kong, Weiyi Wu, Chiyu Ma, Zhongyu Ouyang, Peijun Qing, Soroush Vosoughi, Jiang Gui. Proceedings of the 2025 Conference on Empirical Methods in Natural Language Processing. 2025.

MOTIVATION: An important application of microarray technology is to relate gene expression profiles to various clinical phenotypes of patients. Success has been demonstrated in molecular classification of cancer in which the gene expression data serve as predictors and different types of cancer serve as a categorical outcome variable. However, there has been less research in linking gene expression profiles to the censored survival data such as patients' overall survival time or time to cancer relapse. It would be desirable to have models with good prediction accuracy and parsimony property. RESULTS: We propose to use the L(1) penalized estimation for the Cox model to select genes that are relevant to patients' survival and to build a predictive model for future prediction. The computational difficulty associated with the estimation in the high-dimensional and low-sample size settings can be efficiently solved by using the recently developed least-angle regression (LARS) method. Our simulation studies and application to real datasets on predicting survival after chemotherapy for patients with diffuse large B-cell lymphoma demonstrate that the proposed procedure, which we call the LARS-Cox procedure, can be used for identifying important genes that are related to time to death due to cancer and for building a parsimonious model for predicting the survival of future patients. The LARS-Cox regression gives better predictive performance than the L(2) penalized regression and a few other dimension-reduction based methods. CONCLUSIONS: We conclude that the proposed LARS-Cox procedure can be very useful in identifying genes relevant to survival phenotypes and in building a parsimonious predictive model that can be used for classifying future patients into clinically relevant high- and low-risk groups based on the gene expression profile and survival times of previous patients.