Identifying whether a mixed quantum state is uniquely determined among all states (UDA) by its local marginals is a basic problem in quantum information theory. We establish necessary and sufficient conditions under which several classes of multipartite mixed states are UDA by theirk-partite marginals. We also prove structural properties based on ranges and marginals, and formulate a recursive procedure for the determination of UDA states. We show that sufficiently high rank rules out unique determination from fixed-order marginals, implying that almost all multipartite mixed states are not UDA from such marginals. Finally, we completely characterize the additivity of bipartite UDA states, three-qubit and several families ofn-qubit product UDA states. These results clarify the boundary between UDA and non-UDA mixed states and provide a framework for local-marginal reconstruction and related certification tasks.