SUMMARY: Structural visualization and analysis are fundamental to explore macromolecular functions. Here, we present a novel integrative web-based virtual reality (VR) system-VRmol, to visualize and study molecular structures in an immersive virtual environment. Importantly, it is integrated with multiple online databases and is able to couple structure studies with associated genomic variations and drug information in a visual interface by cloud-based drug docking. VRmol thus can serve as an integrative platform to aid structure-based translational research and drug design. AVAILABILITY AND IMPLEMENTATION: VRmol is freely available (https://VRmol.net), with detailed manual and tutorial (https://VRmol.net/docs). The code of VRmol is available as open source under the MIT license at http://github.com/kuixu/VRmol. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

One of the most compelling challenges of the next decade is the "last-meter" problem, extending the expanding data network into end-user data-collection and monitoring devices. PicoRadio supports the assembly of an ad hoc wireless network of self-contained mesoscale, low-cost, low-energy sensor and monitor nodes. While technology advances have made it conceivable to deploy wireless networks of heterogeneous nodes, the design of a low-power, low-cost, adaptive node in a reduced time to market is still a challenge. We present a design methodology for PicoRadio Networks, from system conception and optimization to silicon platform implementation. For each phase of the design, we demonstrate the applicability of our methodology through promising experimental results.

Targeted at multi-hop wireless sensor networks, a set of low power MAC design principles have been proposed, and a novel ultra-low power MAC is designed to be distributed in nature to support scalability, survivability and adaptability requirements. Simple CSMA and spread spectrum techniques are combined to trade off bandwidth and power efficiency. A distributed algorithm is used to do dynamic channel assignment. A novel wake-up radio scheme is incorporated to take advantage of new radio technologies. The notion of mobility awareness is introduced into an adaptive protocol to reduce network maintenance overhead. The resulting protocol shows much higher power efficiency for typical sensor network applications.