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Sabrina Maniscalco

dblp:133/2154 · DBLP profile ↗
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1ranked-venue papers
0as first author
1since 2021 · last 2024
0000-0001-8559-0828ORCID · verified

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1 · 1 since 2021

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 1 heaviest of 1, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › genomics › computational genomics
disease gene prioritization
0.812024
Disease gene prioritization with quantum walks · Bioinform. 2024

Methods — techniques the papers use, named apart from their topics

enrichment analysis · 0.8cross-validation · 0.8continuous-time quantum walk · 0.8
YearPublicationVenuePosition
2024 Disease gene prioritization with quantum walks
abstract
MOTIVATION: Disease gene prioritization methods assign scores to genes or proteins according to their likely relevance for a given disease based on a provided set of seed genes. This scoring can be used to find new biologically relevant genes or proteins for many diseases. Although methods based on classical random walks have proven to yield competitive results, quantum walk methods have not been explored to this end. RESULTS: We propose a new algorithm for disease gene prioritization based on continuous-time quantum walks using the adjacency matrix of a protein-protein interaction (PPI) network. We demonstrate the success of our proposed quantum walk method by comparing it to several well-known gene prioritization methods on three disease sets, across seven different PPI networks. In order to compare these methods, we use cross-validation and examine the mean reciprocal ranks of recall and average precision values. We further validate our method by performing an enrichment analysis of the predicted genes for coronary artery disease. AVAILABILITY AND IMPLEMENTATION: The data and code for the methods can be accessed at https://github.com/markgolds/qdgp.
Harto Saarinen, Mark Goldsmith, Rui-Sheng Wang, Joseph Loscalzo, Sabrina Maniscalco
Bioinform.5