Sara Rampazzi

dblp:135/7828 · DBLP profile ↗
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29ranked-venue papers
2as first author
21since 2021 · last 2026
0000-0002-3630-6269ORCID · verified

Domains — the database's venue-derived domains; a paper can count in several

Security and privacy · 21 · 17 since 2021Systems, architecture and hardware · 3 · 1 first-author · 2 since 2021Applied, interdisciplinary, general and emerging computing · 3 · 1 first-author · 1 since 2021Artificial intelligence and machine learning · 2 · 1 first-author · 1 since 2021Computer networks · 1Software engineering, systems software and programming languages · 1 · 1 first-author
YearPublicationVenuePosition
2026 The Heat is On: Understanding and Mitigating Vulnerabilities of Thermal Image Perception in Autonomous Systems
S. Hrushikesh Bhupathiraju, Shaoyuan Xie, Michael Clifford, Qi Alfred Chen, Takeshi Sugawara 0001, Sara Rampazzi
NDSS6
2026 The Final Security Frontier: Using Privacy-Preserving Computation to Secure Satellite Rendezvous and Proximity Operations
Caroline M. Brandon, Carson Stillman, Joel Hirschmann, Sara Rampazzi, Marina Blanton, Christopher Petersen, Kevin R. B. Butler
WISEC4
2026 To Go or Not to Go: Shedding Light on Traffic Light Signal Manipulation and Defense Strategies
abstract
Connected autonomous vehicles must accurately detect, and adhere, to traffic light signals to ensure safe and efficient traffic flow. Misinterpretation of traffic lights can result in potential safety issues for drivers and pedestrians. Recent work demonstrated attacks that projected structured light patterns onto vehicle cameras, causing traffic signs and traffic light color misinterpretation. In this work, we characterize a novel vulnerability of traffic light physical structures that can be exploited by attackers to deceive recognition systems. When visible and invisible laser light is projected onto traffic lights, it is scattered by its internal reflectors. To a vehicle’s camera, the reflected light appears the same as a genuine light source, resulting in dangerous red and green traffic light status misclassifications. We evaluate our attack against three state-of-the-art traffic light recognition models and show successful misclassification up to 25 m from the target traffic light. Furthermore, the attack succeeds both in daytime and nighttime conditions both in static and moving vehicle scenarios up to 10 km/h speed. To mitigate this threat, we propose a detection system based on light texture patterns that achieve 100% TPR and 1.8% FPR in our real-world scenarios.
S. Hrushikesh Bhupathiraju, Takami Sato, Michael Clifford, Takeshi Sugawara 0001, Qi Alfred Chen, Sara Rampazzi
ACM Trans. Cyber Phys. Syst.6
2025 EM-Flow: Advanced Electromagnetic Control Flow Verification for Embedded Systems
abstract
Embedded devices play a major role in supporting critical infrastructure, but lack many of the security pro-tections of sophisticated systems. Determining whether these devices are compromised is, therefore, a challenge. In this work, we describe a novel control flow verification methodology via electromagnetic (EM) emanations. We design a framework that incorporates signal processing and training to detect subtle control flow deviations as small as three clock cycles, the minimum required to execute a return with malicious activity on modern embedded hardware. Our methodology leverages basic block detection, enabling the discovery of these subtle control flow deviations that escape conventional detection approaches. We evaluate our framework's ability to detect insertion and modification control flow attacks on six different case studies of real-world critical operations and two processors featuring different architectures. Our results show 96.6% detection accuracy across all tested programs and attacks. Finally, we show the transferability of our methodology to different instances of our evaluated processors, reaching up to 98.7% convergence with our baseline models while requiring a third of the collected EM samples compared to standard retraining. In doing so, we reveal the feasibility of fine-grained EM-based control flow monitoring for low-power microcontrollers.
Carson Stillman, Jennifer Sheldon, Ian Y. Garrett, Patrick Traynor, Ryan M. Gerdes, Sara Rampazzi, Kevin R. B. Butler
ACSAC6
2025 Enabling Plausible Deniability in Flash-based Storage through Data Permutation
abstract
Plausible deniability (PD) allows at-risk users to deny the existence of their sensitive data stored on storage devices. This is critical to protect the privacy and the personal safety of users, as adversaries might force users to decrypt their devices, risking the disclosure of sensitive data that could endanger their lives and liberty. In this work, we show how current PD systems built on flash memory fail to obscure distinguishable data layouts created when hidden data is written. This deficiency makes them vulnerable to coercive adversaries who can capture single or multiple data snapshots of storage devices for scrutiny. To defend against this threat, we propose MUTE, a perMUTation-based PD systEm designed for flash memory. Building upon widely-adopted full disk encryption (FDE) mechanisms that provide device-level data encryption, MUTE modifies the distribution of initialization vectors (IV s) for encryption blocks within FDE, translating the hidden data into a permutation derived from the IV. Unlike other PD solutions, MUTE allows for storing hidden data without requiring the reduction of storage capacity. Moreover, it preserves the plausible deni-ability of the hidden data in a provably secure manner by maintaining the original logic of data operations on the flash memory without changing the data layout. We implement MUTE in the flash translation layer (FTL) of flash-based SSDs using FEMU, a widely-used emulator supporting flash mem-ory research. Our evaluation with various micro-benchmarks and real-world workloads demonstrates that MUTE provides practical write and read throughputs of 23.4 MB/s and 15.7 MB/s and a capacity of 25.3 GB for hidden data in a 512 GB SSD, comparable with existing PD systems. MUTE achieves strong PD guarantees for flash-based devices against coercive adversaries, outperforming current PD systems. Index Terms-Plausible Deniability, Data Layout, Flash-based SSDs
Weidong Zhu 0002, Vincent Bindschaedler, Sara Rampazzi, Kevin R. B. Butler
ACSAC4
2025 Enabling Secure and Efficient Data Loss Prevention with a Retention-aware Versioning SSD
Weidong Zhu 0002, Carson Stillman, Sara Rampazzi, Kevin R. B. Butler
CCS3
2025 Poster: Recapture Detection Using Disparity Map Obtained from Dual-Pixel Image Sensors
abstract
Recapturing computer monitors with a camera is a common threat to cryptographic techniques designed to verify the origin of images and prevent AI-generated deepfakes. Although depth information can help distinguish a real-world scene from a flat computer monitor, incorporating additional depth sensors is often cost-prohibitive. To address this challenge, we explore the use of dual-pixel (DP) image sensors commonly found in still and smartphone cameras for fast autofocus, as a means to extract depth information for distinguishing real scenes from recaptured ones, without requiring additional hardware. Our signal processing pipeline is composed of (i) a stereo matching algorithm to obtain a disparity map using a pair of images generated from a DP image sensor and (ii) plane fitting to evaluate the flatness of the scene. Our proof-of-concept evaluation on a real-world DP image dataset demonstrates that the proposed method detects recaptured images at 100% accuracy. Similarly, it successfully distinguishes real-world scenes from recaptured deepfake images with >98% accuracy.
Tetsu Ishizue, Sara Rampazzi, Takeshi Sugawara 0001
CCS2
2025 FACE: Faithful Automatic Concept Extraction
abstract
Interpreting deep neural networks through concept-based explanations offers a bridge between low-level features and high-level human-understandable semantics. However, existing automatic concept discovery methods often fail to align these extracted concepts with the model’s true decision-making process, thereby compromising explanation faithfulness. In this work, we propose FACE (Faithful Automatic Concept Extraction), a novel framework that combines Non-negative Matrix Factorization (NMF) with a Kullback-Leibler (KL) divergence regularization term to ensure alignment between the model’s original and concept-based predictions. Unlike prior methods that operate solely on encoder activations, FACE incorporates classifier supervision during concept learning, enforcing predictive consistency and enabling faithful explanations. We provide theoretical guarantees showing that minimizing the KL divergence bounds the deviation in predictive distributions, thereby promoting faithful local linearity in the learned concept space. Systematic evaluations on ImageNet, COCO, and CelebA datasets demonstrate that FACE outperforms existing methods across faithfulness and sparsity metrics.
Dipkamal Bhusal, Michael Clifford, Sara Rampazzi, Nidhi Rastogi
NeurIPS3
2025 Sound of Interference: Electromagnetic Eavesdropping Attack on Digital Microphones Using Pulse Density Modulation
Arifu Onishi, S. Hrushikesh Bhupathiraju, Rishikesh Bhatt, Sara Rampazzi, Takeshi Sugawara 0001
USENIX Security Symposium4
2025 SrFTL: Leveraging Storage Semantics for Effective Ransomware Defense in Flash-based SSDs
abstract
Ransomware attacks have become increasingly frequent and high-profile, resulting in billions of dollars in data and operational losses annually. Current mechanisms typically deploy defenses in vulnerable operating systems, making them susceptible to advanced adversaries capable of compromising the OS. While implementing defense mechanisms within storage devices can address this vulnerability, they lack detection accuracy due to their inability to access data semantics, such as file system metadata. Moreover, these methods only expose block-level interfaces without file-level information, limiting the usability and practicality of data recovery management. Therefore, we develop SrFTL , a novel ransomware defense framework that allows leveraging data semantics for accurate ransomware detection and effective file-level data recovery against data compromise. Specifically, SrFTL employs defense enforcement within the flash translation layer (FTL) of SSDs. Then, SrFTL combines the secure enclave with the modified FTL through a secure channel to enable flexible ransomware defenses within the enclave. Finally, SrFTL deploys ransomware classification and data recovery defenses in the enclave, providing high detection accuracy and low-cost data recovery. Our evaluation demonstrates that SrFTL achieves zero false positives and negatives when detecting our collected real-world ransomware samples and benign applications, outperforming current FTL-level solutions (e.g., MimosaFTL). Moreover, SrFTL introduces on average a trivial performance overhead of 1.5% compared with a regular SSD. Finally, evaluating against multiple real-world ransomware samples, SrFTL enables fast data recovery with an average time of 9.3 seconds. SrFTL thus bridges the semantic gap between the FTL and OS-level file information to stop ransomware while maintaining the integrity and authenticity of employed defenses.
Weidong Zhu 0002, Grant Hernandez, Washington Garcia, Jing (Dave) Tian, Sara Rampazzi, Kevin R. B. Butler
ACM Trans. Storage5
2024 PASA: Attack Agnostic Unsupervised Adversarial Detection Using Prediction & Attribution Sensitivity Analysis
abstract
Deep neural networks for classification are vulnerable to adversarial attacks, where small perturbations to input samples lead to incorrect predictions. This susceptibility, combined with the black-box nature of such networks, limits their adoption in critical applications like autonomous driving. Feature-attribution-based explanation methods provide relevance of input features for model predictions on input samples, thus explaining model decisions. However, we observe that both model predictions and feature attributions for input samples are sensitive to noise. We develop a practical method for this characteristic of model prediction and feature attribution to detect adversarial samples. Our method, PASA, requires the computation of two test statistics using model prediction and feature attribution and can reliably detect adversarial samples using thresholds learned from benign samples. We validate our lightweight approach by evaluating the performance of PASA on varying strengths of FGSM, PGD, BIM, and CW attacks on multiple image and non-image datasets. On average, we outperform state-of-the-art statistical unsupervised adversarial detectors on CIFAR-10 and ImageNet by 14% and 35% ROC-AUC scores, respectively. Moreover, our approach demonstrates competitive performance even when an adversary is aware of the defense mechanism.
Dipkamal Bhusal, Md Tanvirul Alam, Monish Kumar Manikya Veerabhadran, Michael Clifford, Sara Rampazzi, Nidhi Rastogi
EuroS&P5
2024 Invisible Reflections: Leveraging Infrared Laser Reflections to Target Traffic Sign Perception
Takami Sato, S. Hrushikesh Bhupathiraju, Michael Clifford, Takeshi Sugawara 0001, Qi Alfred Chen, Sara Rampazzi
NDSS6
2024 AquaSonic: Acoustic Manipulation of Underwater Data Center Operations and Resource Management
abstract
Underwater data centers (UDCs) hold promise as next-generation data storage due to their energy efficiency and environmental sustainability benefits. While the natural cooling properties of water save power, the isolated aquatic environment and long-range sound propagation characteristics in water create unique vulnerabilities which differ from those of on-land data centers. Our research discovers the unique vulnerabilities of fault-tolerant storage devices, resource allocation software, and distributed file systems to acoustic injection attacks in UDCs. With a realistic testbed approximating UDC server operations, we empirically characterize the capabilities of acoustic injection underwater and find that an attacker can reduce fault-tolerant RAID 5 storage system throughput by 17% up to 100%. Our closed-water analyses reveal that an attacker can (i) cause unresponsiveness and automatic node removal in a distributed filesystem with only 2.4 minutes of sustained acoustic injection, (ii) induce a distributed database’s latency to increase by up to 92.7% to reduce system reliability, and (iii) induce load-balance managers to redirect up to 74% of resources to a target server to cause overload or force resource colocation. Furthermore, we perform open-water experiments in a lake and find that an attacker can cause controlled throughput degradation at the maximum allowable distance of 6.35 m using a commercial speaker. We also investigate and discuss the effectiveness of standard defenses against acoustic injection attacks. Finally, we formulate a novel machine learning-based detection system that reaches 0% False Positive Rate and 98.2% True Positive Rate trained on our dataset of profiled hard disk drives under 30-second FIO benchmark execution. With this work, we aim to help manufacturers proactively protect UDCs against acoustic injection attacks and ensure the security of subsea computing infrastructures.
Jennifer Sheldon, Weidong Zhu 0002, Adnan Abdullah, S. Hrushikesh Bhupathiraju, Takeshi Sugawara 0001, Kevin R. B. Butler, Md Jahidul Islam, Sara Rampazzi
SP8
2023 SoK: Modeling Explainability in Security Analytics for Interpretability, Trustworthiness, and Usability
abstract
Interpretability, trustworthiness, and usability are key considerations in high-stake security applications, especially when utilizing deep learning models. While these models are known for their high accuracy, they behave as black boxes in which identifying important features and factors that led to a classification or a prediction is difficult. This can lead to uncertainty and distrust, especially when an incorrect prediction results in severe consequences. Thus, explanation methods aim to provide insights into the inner working of deep learning models. However, most explanation methods provide inconsistent explanations, have low fidelity, and are susceptible to adversarial manipulation, which can reduce model trustworthiness. This paper provides a comprehensive analysis of explainable methods and demonstrates their efficacy in three distinct security applications: anomaly detection using system logs, malware prediction, and detection of adversarial images. Our quantitative and qualitative analysis1 reveals serious limitations and concerns in state-of-the-art explanation methods in all three applications. We show that explanation methods for security applications necessitate distinct characteristics, such as stability, fidelity, robustness, and usability, among others, which we outline as the prerequisites for trustworthy explanation methods.
Dipkamal Bhusal, Rosalyn Shin, Ajay Ashok Shewale, Monish Kumar Manikya Veerabhadran, Michael Clifford, Sara Rampazzi, Nidhi Rastogi
ARES6
2023 Deep Note: Can Acoustic Interference Damage the Availability of Hard Disk Storage in Underwater Data Centers?
abstract
The growing worldwide attention toward large-scale subsea data centers has garnered substantial interest from commercial entities which have built and deployed underwater prototypes since 2015. These data centers utilize hard disk drives (HDDs) as a cost-effective method of data storage. However, researchers have demonstrated that acoustic waves can affect the availability and integrity of HDDs and applications that rely on them. These studies are all conducted in air on commercial laptops, hence their applicability and implications in submerged environments remain unexplored. In this position paper, we investigate potential vulnerabilities of storage devices deployed in underwater data centers and subsea storage platforms against targeted acoustic attacks. Based on our initial investigation of a simplified scenario, a victim HDD deployed in an enclosed submerged container is especially vulnerable to those acoustic attacks, which at frequencies ranging from 300 Hz 1300 Hz can result in up to 100% throughput loss and application crashes. Based on these findings, we argue that further study is necessary to assess underwater storage system security and develop effective defenses against overlooked acoustic attacks.
Jennifer Sheldon, Weidong Zhu 0002, Adnan Abdullah, Kevin R. B. Butler, Md Jahidul Islam, Sara Rampazzi
HotStorage6
2023 Shimware: Toward Practical Security Retrofitting for Monolithic Firmware Images
abstract
In today’s era of the Internet of Things, we are surrounded by security- and safety-critical, network-connected devices. In parallel with the rise in attacks on such devices, we have also seen an increase in devices that are abandoned, reached the end of their support periods, or will not otherwise receive future security updates. While this issue exists for a wide array of devices, those that use monolithic firmware, where the code and data are opaquely intermixed, have traditionally been difficult to examine and protect.
Eric Gustafson, Paul Grosen, Nilo Redini, Saagar Jha, Andrea Continella, Ruoyu Wang 0001, Kevin Fu, Sara Rampazzi, Christopher Krügel, Giovanni Vigna
RAID8
2023 Side Eye: Characterizing the Limits of POV Acoustic Eavesdropping from Smartphone Cameras with Rolling Shutters and Movable Lenses
abstract
Our research discovers how the rolling shutter and movable lens structures widely found in smartphone cameras modulate structure-borne sounds onto camera images, creating a point-of-view (POV) optical-acoustic side channel for acoustic eavesdropping. The movement of smartphone camera hardware leaks acoustic information because images unwittingly modulate ambient sound as imperceptible distortions. Our experiments find that the side channel is further amplified by intrinsic behaviors of Complementary Metal-oxide–Semiconductor (CMOS) rolling shutters and movable lenses such as in Optical Image Stabilization (OIS) and Auto Focus (AF). Our paper characterizes the limits of acoustic information leakage caused by structure-borne sound that perturbs the POV of smartphone cameras. In contrast with traditional optical-acoustic eavesdropping on vibrating objects, this side channel requires no line of sight and no object within the camera’s field of view (images of a ceiling suffice). Our experiments test the limits of this side channel with a novel signal processing pipeline that extracts and recognizes the leaked acoustic information. Our evaluation with 10 smartphones on a spoken digit dataset reports 80.66%, 91.28%, and 99.67% accuracies on recognizing 10 spoken digits, 20 speakers, and 2 genders respectively. We further systematically discuss the possible defense strategies and implementations. By modeling, measuring, and demonstrating the limits of acoustic eavesdropping from smartphone camera image streams, our contributions explain the physics-based causality and possible ways to reduce the threat on current and future devices.
Yan Long 0002, Pirouz Naghavi, Blas Kojusner, Kevin R. B. Butler, Sara Rampazzi, Kevin Fu
SP5
2023 You Can't See Me: Physical Removal Attacks on LiDAR-based Autonomous Vehicles Driving Frameworks
S. Hrushikesh Bhupathiraju, Pirouz Naghavi, Takeshi Sugawara 0001, Z. Morley Mao, Sara Rampazzi
USENIX Security Symposium6
2023 Auditory Eyesight: Demystifying μs-Precision Keystroke Tracking Attacks on Unconstrained Keyboard Inputs
Yazhou Tu, Liqun Shan, Md. Imran Hossen, Sara Rampazzi, Kevin R. B. Butler, Xiali Hei 0001
USENIX Security Symposium4
2023 EMI-LiDAR: Uncovering Vulnerabilities of LiDAR Sensors in Autonomous Driving Setting using Electromagnetic Interference
abstract
Autonomous Vehicles (AVs) using LiDAR-based object detection systems are rapidly improving and becoming an increasingly viable method of transportation. While effective at perceiving the surrounding environment, these detection systems are shown to be vulnerable to attacks using lasers which can cause obstacle misclassifications or removal. These laser attacks, however, are challenging to perform, requiring precise aiming and accuracy. Our research exposes a new threat in the form of Intentional Electro-Magnetic-Interference (IEMI), which affects the time-of-flight (TOF) circuits that make up modern LiDARs. We show that these vulnerabilities can be exploited to force the AV Perception system to misdetect, misclassify objects, and perceive non-existent obstacles. We evaluate the vulnerability in three AV perception modules (PointPillars, PointRCNN, and Apollo) and show how the classification rate drops below 50%. We also analyze the impact of the IEMI injection on two fusion models (AVOD and Frustum-ConvNet) and in real-world scenarios. Finally, we discuss potential countermeasures and propose two strategies to detect signal injection.
S. Hrushikesh Bhupathiraju, Jennifer Sheldon, Luke A. Bauer, Vincent Bindschaedler, Takeshi Sugawara 0001, Sara Rampazzi
WISEC6
2022 Analyzing the Monetization Ecosystem of Stalkerware
abstract
Stalkerware is a form of malware that allows for the abusive monitoring of intimate partners. Primarily deployed on information-rich mobile platforms, these malicious applications allow for collecting information about a victim’s actions and behaviors, including location data, call audio, text messages, photos, and other personal details. While stalkerware has received increased attention from the security community, the ways in which stalkerware authors monetize their efforts have not been explored in depth. This paper represents the first large-scale technical analysis of monetization within the stalkerware ecosystem. We analyze the code base of 6,432 applications collected by the Coalition Against Stalkerware to determine their monetization strategies. We find that while far fewer stalkerware apps use ad libraries than normal apps, 99% of those that do use Google AdMob. We also find that payment services range from traditional in-app billing to cryptocurrency. Finally, we demonstrate that Google’s recent change to their Terms of Service (ToS) did not eliminate these applications, but instead caused a shift to other payment processors, while the apps can still be found on the Play Store; we verify through emulation that these apps often operate in blatant contravention of the ToS. Through this analysis, we find that the heterogeneity of markets and payment processors means that while point solutions can have impact on monetization, a multi-pronged solution involving multiple stakeholders is necessary to mitigate the financial incentive for developing stalkerware.
Cassidy Gibson, Vanessa Frost, Katie Platt, Washington Garcia, Luis Vargas, Sara Rampazzi, Vincent Bindschaedler, Patrick Traynor, Kevin R. B. Butler
Proc. Priv. Enhancing Technol.6
2020 Automating decontamination of N95 masks for frontline workers in COVID-19 pandemic: poster abstract
abstract
In response to the N95 mask shortage caused by the COVID-19 pandemic, the US CDC has recognized moist-heat as one of the most effective and accessible methods for decontaminating N95 masks for reuse. However, it is challenging to reliably deploy this technique in healthcare settings due to a lack of specialized equipment capable of ensuring proper decontamination conditions. To this end, we developed a wireless sensor platform for moist-heat decontamination process verification, capable of monitoring hundreds of masks simultaneously in commercially available heating systems. Our easy-to-use, low-power, low-cost, scalable platform can be broadly deployed to protect front-line healthcare workers by lowering their risk of infection from reused N95 masks.
Yan Long 0002, Alexander Curtiss, Sara Rampazzi, Josiah D. Hester, Kevin Fu
SenSys3
2020 Light Commands: Laser-Based Audio Injection Attacks on Voice-Controllable Systems
Takeshi Sugawara 0001, Benjamin Cyr, Sara Rampazzi, Daniel Genkin, Kevin Fu
USENIX Security Symposium3
2019 Adversarial Sensor Attack on LiDAR-based Perception in Autonomous Driving
abstract
In Autonomous Vehicles (AVs), one fundamental pillar is perception,which leverages sensors like cameras and LiDARs (Light Detection and Ranging) to understand the driving environment. Due to its direct impact on road safety, multiple prior efforts have been made to study its the security of perception systems. In contrast to prior work that concentrates on camera-based perception, in this work we perform the first security study of LiDAR-based perception in AV settings, which is highly important but unexplored. We consider LiDAR spoofing attacks as the threat model and set the attack goal as spoofing obstacles close to the front of a victim AV. We find that blindly applying LiDAR spoofing is insufficient to achieve this goal due to the machine learning-based object detection process.Thus, we then explore the possibility of strategically controlling the spoofed attack to fool the machine learning model. We formulate this task as an optimization problem and design modeling methods for the input perturbation function and the objective function.We also identify the inherent limitations of directly solving the problem using optimization and design an algorithm that combines optimization and global sampling, which improves the attack success rates to around 75%. As a case study to understand the attack impact at the AV driving decision level, we construct and evaluate two attack scenarios that may damage road safety and mobility.We also discuss defense directions at the AV system, sensor, and machine learning model levels.
Chaowei Xiao, Benjamin Cyr, Yimeng Zhou, Won Park, Sara Rampazzi, Qi Alfred Chen, Kevin Fu, Z. Morley Mao
CCS6
2019 Trick or Heat?: Manipulating Critical Temperature-Based Control Systems Using Rectification Attacks
abstract
Temperature sensing and control systems are widely used in the closed-loop control of critical processes such as maintaining the thermal stability of patients, or in alarm systems for detecting temperature-related hazards. However, the security of these systems has yet to be completely explored, leaving potential attack surfaces that can be exploited to take control over critical systems.
Yazhou Tu, Sara Rampazzi, Bin Hao, Angel Rodriguez, Kevin Fu, Xiali Hei 0001
CCS2
2019 Protease target prediction via matrix factorization
abstract
MOTIVATION: Protein cleavage is an important cellular event, involved in a myriad of processes, from apoptosis to immune response. Bioinformatics provides in silico tools, such as machine learning-based models, to guide the discovery of targets for the proteases responsible for protein cleavage. State-of-the-art models have a scope limited to specific protease families (such as Caspases), and do not explicitly include biological or medical knowledge (such as the hierarchical protein domain similarity or gene-gene interactions). To fill this gap, we present a novel approach for protease target prediction based on data integration. RESULTS: By representing protease-protein target information in the form of relational matrices, we design a model (i) that is general and not limited to a single protease family, and (b) leverages on the available knowledge, managing extremely sparse data from heterogeneous data sources, including primary sequence, pathways, domains and interactions. When compared with other algorithms on test data, our approach provides a better performance even for models specifically focusing on a single protease family. AVAILABILITY AND IMPLEMENTATION: https://gitlab.com/smarini/MaDDA/ (Matlab code and utilized data.). SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
Simone Marini, Francesca Vitali, Sara Rampazzi, Andrea Demartini, Tatsuya Akutsu
Bioinform.3
2018 Blue Note: How Intentional Acoustic Interference Damages Availability and Integrity in Hard Disk Drives and Operating Systems
abstract
Intentional acoustic interference causes unusual errors in the mechanics of magnetic hard disk drives in desktop and laptop computers, leading to damage to integrity and availability in both hardware and software such as file system corruption and operating system reboots. An adversary without any special purpose equipment can co-opt built-in speakers or nearby emitters to cause persistent errors. Our work traces the deeper causality of these risks from the physics of materials to the I/O request stack in operating systems for audible and ultrasonic sound. Our experiments show that audible sound causes the head stack assembly to vibrate outside of operational bounds; ultrasonic sound causes false positives in the shock sensor, which is designed to prevent a head crash. The problem poses a challenge for legacy magnetic disks that remain stubbornly common in safety critical applications such as medical devices and other highly utilized systems difficult to sunset. Thus, we created and modeled a new feedback controller that could be deployed as a firmware update to attenuate the intentional acoustic interference. Our sensor fusion method prevents unnecessary head parking by detecting ultrasonic triggering of the shock sensor.
Connor Bolton, Sara Rampazzi, Chaohao Li, Andrew Kwong, Wenyuan Xu 0001, Kevin Fu
IEEE Symposium on Security and Privacy2
2013 Lab on Chip: Portable Optical Device for On-site Multi-parametric Analysis
abstract
Recently the demand dramatically grew up for portable biosensors, providing an on-site multi-parametric measurement. Present instruments, however, are limited by large size and consumption (which prevents portability) and costs (which prevents their usage in some Countries). In this paper, we propose a compact and portable device based on a nano-structured array biochip featuring the Surface Plasmonic Resonance, lighted by a suitable optics and equipped with an 830 nm irradiating LED. The reflected image is detected by an Aptina CMOS sensor and managed by an ARM9 processor which is responsible of the acquisition end processing, performed within 14 sec form the application of the assy. The processor evaluates the average grey level pixel ratio between suitable biochip areas so as to be independent on illumination fluctuations and external noise. Preliminary results indicate a sensitivity close to 10-4 RIU change in the refractive index and applicability of the device to different applications and fields (waste water and food pollution analysis, among the main ones).
Sara Rampazzi, Giovanni Danese, Lucia Fornasari, Francesco Leporati, Franco Marabelli, Nelson Nazzicari, Armand Valsesia
DSD1
2013 A Novel Portable Surface Plasmon Resonance Based Imaging Instrument for On-Site Multi-Analyte Detection
Sara Rampazzi, Francesco Leporati, Giovanni Danese, Lucia Fornasari, Franco Marabelli, Nelson Nazzicari, Andrea Valsesia
FedCSIS1