Positron emission tomography (PET) imaging enables quantitative assessment of tissue physiology. Dynamic pharmacokinetic analysis of PET images requires accurate estimation of the radiotracer plasma input function to derive meaningful parameter estimates, and small discrepancies in parameter estimation can mimic subtle physiologic tissue variation. This study evaluates the impact of input function interpolation method on the accuracy of Patlak kinetic parameter estimation through simulations modeling the pharmacokinetic properties of [68Ga]-PSMA-11. This study evaluated both trained and untrained methods. Although the mean kinetic parameter accuracy was similar across all interpolation models, the trained node weighting interpolation model estimated accurate kinetic parameters with reduced overall variability relative to standard linear interpolation. Trained node weighting interpolation reduced kinetic parameter estimation variance by a magnitude approximating the underlying physiologic differences between normal and diseased prostatic tissue. Overall, this analysis suggests that trained node weighting improves the reliability of Patlak kinetic parameter estimation for [68Ga]-PSMA-11 PET.

Language users are remarkably good at making inferences about speakers' intentions in context, and children learning their native language also display substantial skill in acquiring the meanings of unknown words. These two cases are deeply related: Language users invent new terms in conversation, and language learners learn the literal meanings of words based on their pragmatic inferences about how those words are used. While pragmatic inference and word learning have both been independently characterized in probabilistic terms, no current work unifies these two. We describe a model in which language learners assume that they jointly approximate a shared, external lexicon and reason recursively about the goals of others in using this lexicon. This model captures phenomena in word learning and pragmatic inference; it additionally leads to insights about the emergence of communicative systems in conversation and the mechanisms by which pragmatic inferences become incorporated into word meanings.