Peptide-based drug design targeting “undruggable” proteins remains one of the most critical challenges in modern drug discovery. Conventional peptide-discovery pipelines rely on low-throughput experimental screening, which is both time-consuming and prohibitively expensive. Moreover, existing computational approaches for designing peptides against target proteins typically depend on the availability of high-quality structural information. Although recent structure-prediction tools such as AlphaFold3 have achieved breakthroughs in protein modeling, their accuracy for functional interfaces remains limited. The acquisition of high-resolution structures is often expensive, time-intensive, and particularly challenging for targets with dynamic conformations, further restricting the efficient development of peptide therapeutics. Additionally, current sequence-based generative methods follow a paradigm that relies on known templates, which limits the exploration of sequence space and results in generated peptides lacking diversity and novelty. To address these limitations, we propose a contrastive conditioned diffusion framework for target-specific peptide generation, referred to as PepCCD. It employs a contrastive learning strategy between proteins and peptides to extract sequence-based conditioning representations of target proteins, which serve as precise conditions to guide a pre-trained diffusion model to generate peptide sequences with the desired target specificity. Extensive experiments on multiple benchmark target proteins demonstrate that the peptides designed by PepCCD exhibit strong binding affinity and outperform state-of-the-art methods in terms of diversity and generation efficiency.

Multi-view clustering aims to integrate complementary information from multiple views to achieve better performance than single-view clustering. However, in practical scenarios, the quality of each view is often inconsistent, with some views containing substantial noise or redundant information, which may adversely affect the overall clustering performance. Moreover, existing contrastive learning techniques typically employ overly simplistic strategies for negative sample selection, making them prone to local optima during training and compromising model effectiveness. To address these challenges, this paper proposes a novel information fusion-based deep multi-view contrastive clustering algorithm, termed ECMVC. The proposed method explicitly models both consistency and complementarity among views and leverages a feature fusion network to enhance the stability and accuracy of clustering in noisy and redundant environments. In addition, we further propose a curriculum-guided contrastive learning approach, where an entropy-driven dynamic scheduler adaptively selects informative negative samples and progressively increases the training difficulty. This curriculum-guided mechanism enables faster convergence and more stable optimization. Experiments on multiple benchmark datasets demonstrate the effectiveness of the proposed method.

Textual emotion detection is playing an important role in the human-computer interaction domain. The mainstream methods of textual emotion detection are extracting semantic features and fine-tuning by language models. Due to the information redundancy in semantics, it is difficult for these methods to accurately detect all the emotions implied in the text. The prompting method has been shown to make the language models more purposeful in prediction by filling the cloze or prefix prompts defined. Therefore, we design a prompting method for multi-label classification. To stabilize the output, we design two consistency training strategies. We experiment on two multi-label emotion classification datasets: Ren-CECps and NLPCC2018. Our proposed prompting method with consistency training strategies for multi-label textual emotion detection (PC-MTED) model achieves state-of-the-art Macro F1 scores of 0.5432 and 0.5269, respectively. The experimental results indicate that our proposed method is effective in the multi-label textual emotion detection task.