The convergence of large language models (LLMs) and virtual reality (VR) technologies has led to significant breakthroughs across multiple domains, particularly in healthcare and medicine. Owing to its immersive and interactive capabilities, VR technology has demonstrated exceptional utility in surgical simulation, rehabilitation, physical therapy, mental health, and psychological treatment. By creating highly realistic and precisely controlled environments, VR not only enhances the efficiency of medical training but also enables personalized therapeutic approaches for patients. The convergence of LLMs and VR extends the potential of both technologies. LLM-empowered VR can transform medical education through interactive learning platforms and address complex healthcare challenges using comprehensive solutions. This convergence enhances the quality of training, decision-making, and patient engagement, paving the way for innovative healthcare delivery. This study aims to comprehensively review the current applications, research advancements, and challenges associated with these two technologies in healthcare and medicine. The rapid evolution of these technologies is driving the healthcare industry toward greater intelligence and precision, establishing them as critical forces in the transformation of modern medicine.

Given a target grayscale image and a reference color image, exemplar-based image colorization aims to generate a visually natural-looking color image by transforming meaningful color information from the reference image to the target image. It remains a challenging problem due to the differences in semantic content between the target image and the reference image. In this paper, we present a novel globally and locally semantic colorization method called exemplar-based conditional broad-GAN, a broad generative adversarial network (GAN) framework, to deal with this limitation. Our colorization framework is composed of two sub-networks: the match sub-net and the colorization sub-net. We reconstruct the target image with a dictionary-based sparse representation in the match sub-net, where the dictionary consists of features extracted from the reference image. To enforce global-semantic and local-structure self-similarity constraints, global-local affinity energy is explored to constrain the sparse representation for matching consistency. Then, the matching information of the match sub-net is fed into the colorization sub-net as the perceptual information of the conditional broad-GAN to facilitate the personalized results. Finally, inspired by the observation that a broad learning system is able to extract semantic features efficiently, we further introduce a broad learning system into the conditional GAN and propose a novel loss, which substantially improves the training stability and the semantic similarity between the target image and the ground truth. Extensive experiments have shown that our colorization approach outperforms the state-of-the-art methods, both perceptually and semantically.