The 2025 ISSAC conference in Guanajuato, Mexico, marks the 50th event in this significant series, making it an ideal moment to reflect on the field’s history. This paper reviews the formative years of symbolic computation up to 1975, fifty years ago. By revisiting a period unfamiliar to most current participants, this survey aims to shed light on once-pressing issues that are now largely resolved and to highlight how some of today’s challenges were recognized earlier than expected.