Drug-resistant epilepsy (DRE) patients typically require surgical intervention or neurostimulation. Therefore, accurate localization of the seizure onset zone (SOZ) is essential for effective clinical intervention. Although some physiologically meaningful parameters of neural computational models show substantial differences across brain regions during seizures, few studies pay attention to applying these model parameters to SOZ localization. To investigate whether the parameter can be used for accurate SOZ localization, the unscented kalman filter (UKF) is employed to estimate the excitatory-inhibitory balance parameter c from the Z6 neural computational model using DRE patients' electrocorticography (ECoG). The results indicate that this parameter follows a unimodal distribution during the pre-ictal period and the post-ictal period, while exhibiting a bimodal distribution during the ictal period. Then, the distribution of this parameter is combined with machine learning methods, and a bagged tree classifier is constructed to localize the SOZ. The classification results demonstrate that the classifier based on parameter distributions exhibits excellent performance, particularly during the post-ictal period, with an average accuracy of 91.60% . Interestingly, SOZ localization is more accurate when no lesions are detected on magnetic resonance imaging (MRI) compared to when lesions are present. Finally, the model parameter distributions of the SOZs are utilized to predict the outcome of epilepsy surgery. Of note, the results demonstrate that the parameter distribution accurately predicts surgical outcomes with an average accuracy of 92.56% . These findings suggest that the distribution of neural computational model parameters may serve as biomarkers for SOZ localization and epilepsy surgery outcome prediction, providing valuable support and assistance for clinical decision-making.

Video colorization aims to add color to black-and-white films. However, propagating color information to the whole video clip accurately is a challenging task. In this paper, we propose Flow-Guided Transformer for Video Colorization (FGTVC), consisting of a Global Motion Aggregation (GMA) module, Residual modules, Flow-Guided Attention blocks (FGAB) based on encoder and decoder, to exploit the information from the neighbor patch with high similarity for each video patch colorization. Specifically, we employ Transformer to capture the long-distance dependencies between frames and learn non-local self-similarity in the frame. To overcome the shortcomings of previous optical flow-based methods, FGAB enjoys the guidance of optical flow to sample elements from spatio-temporal adjacent frames when calculating self-attention. Experiments show that the proposed FGTVC has an outstanding performance than the state-of-the-art methods. In addition, comprehensive findings demonstrate the superiority of our framework in real-world video colorization tasks.

Medicinal plants are the main source of natural metabolites with specialised pharmacological activities and have been widely examined by plant researchers. Numerous omics studies of medicinal plants have been performed to identify molecular markers of species and functional genes controlling key biological traits, as well as to understand biosynthetic pathways of bioactive metabolites and the regulatory mechanisms of environmental responses. Omics technologies have been widely applied to medicinal plants, including as taxonomics, transcriptomics, metabolomics, proteomics, genomics, pangenomics, epigenomics and mutagenomics. However, because of the complex biological regulation network, single omics usually fail to explain the specific biological phenomena. In recent years, reports of integrated multi-omics studies of medicinal plants have increased. Until now, there have few assessments of recent developments and upcoming trends in omics studies of medicinal plants. We highlight recent developments in omics research of medicinal plants, summarise the typical bioinformatics resources available for analysing omics datasets, and discuss related future directions and challenges. This information facilitates further studies of medicinal plants, refinement of current approaches and leads to new ideas.

Learning representations for multimedia content is critical for multimedia recommendation. Current representation learning methods roughly fall into two groups: (1) using the historical interactions to create ID embeddings of users and items, and (2) treating multi-modal data as the side information of items to enrich their ID embeddings. Each user-item interaction offers the supervisory signal to optimize the representation learning by the traditional supervised learning paradigm. Due to the overlook of the multi-modal patterns ($e.g.$, co-occurrence of visual, acoustic, textual features in micro-videos a user saw before, and her behavioral features) hidden in the data, these methods are insufficient to create powerful representations and obtain satisfactory recommendation accuracy. To capture multi-modal patterns in the data itself, we go beyond the supervised learning paradigm, and incorporate the idea of self-supervised learning (SSL) into multimedia recommendation. Specifically, SSL consists of two components: (1) data augmentation upon multi-modal contents, where we design three operators — feature dropout (FD), feature masking (FM), feature fine and coarse spaces (FAC) — to generate multiple views of individual items; and (2) contrastive learning, which differentiates the views of an item from the others’ to distill additional supervisory signals. Clearly, SSL enables us to explore and exhibit the underlying relations among modalities, thereby resulting in powerful representations. We denote the generic framework by Self-supervised Learning-guided Multimedia Recommendation (SLMRec). Extensive experiments are performed on three real-world datasets, showing that SLMRec achieves significant improvements over several state-of-the-art baselines like LightGCN [1], MMGCN [2]. Further analysis shows how SSL affects recommendation performance.

The main idea of multimedia recommendation is to introduce the profile content of multimedia documents as an auxiliary, so as to endow recommenders with generalization ability and gain better performance. However, recent studies using non-uniform datasets roughly fuse single-modal features into multi-modal features and adopt the strategy of directly maximizing the likelihood of user preference scores, leading to the single-modal bias. Owing to the defect in architecture, there is still room for improvement for recent multimedia recommendation.

Transformer typically enjoys larger model capacity but higher computational loads than convolutional neural network (CNN) in vision tasks. In this letter, the advantages of such two networks are fused for achieving effective and efficient real image denoising. We propose a hybrid denoising model based on Transformer Encoder and Convolutional Decoder Network (TECDNet). The Transformer based on novel radial basis function (RBF) attention is used as encoder to improve the representation capability of overall model. In decoder, the residual CNN instead of Transformer is adopted to greatly reduce computational complexity of the whole denoising network. Extensive experimental results on real images show that TECDNet achieves the state-of-the-art denosing performance with relatively low computational cost.

As a fundamental task of natural language processing, text classification has been widely used in various applications such as sentiment analysis and spam detection. In recent years, the continuous-valued word embedding learned by neural network attaches extensive attentions. Although word embedding achieves impressive results in capturing similarities and regularities between words, it fails to highlight important words for identifying text category. Such deficiency could be attenuated by word weight, which conveys word contribution in text categorization. Toward this end, we propose an effective text classification scheme by incorporating word weight into word embedding in this paper. Specifically, in order to enrich word representation, the bidirectional gated recurrent units (Bi-GRU) is first employed to grasp context information of words. Then the word weights yielded by term frequency (TF) are used to modulate the word representation of Bi-GRU for constructing text representation. Extensive experimental results on several large text datasets verify that the accuracy of our proposed text classification scheme outperforms the state-of-the-art ones.

Many works have devoted to exploring local region information including both the information of the local features in local region and their spatial relationships, but none of these can provide a compact representation of the information. To achieve this, we propose a new approach named Local Visual Similarity (LVS). LVS first calculates the similarities among the local features in a local region and then forms these similarities as a single vector named LVS descriptor. In our experiments, we show that LVS descriptor can preserve local region information with low dimensionality. Besides, experimental results on two public datasets also demonstrate the effectiveness of LVS descriptor.