Time-to-event analysis provides insights into clinical prognosis and treatment recommendations. However, this task is more challenging than standard regression problems due to the presence of censored observations. Additionally, the lack of confidence assessment, model robustness, and prediction calibration raises concerns about the reliability of predictions. To address these challenges, we propose an evidential regression model specifically designed for time-to-event prediction. Our approach computes a degree of belief for the event time occurring within a time interval, without any strict distribution assumption. Meanwhile, the proposed model quantifies both epistemic and aleatory uncertainties using Gaussian Random Fuzzy Numbers and belief functions, providing clinicians with uncertainty-aware survival time predictions. Experimental evaluations using simulated and real-world survival datasets highlight the potential of our approach for enhancing clinical decision-making in survival analysis. • Calculate survival time without strict distribution assumptions. • Quantifies epistemic and aleatory uncertainties via GRFN and belief functions. • Provides uncertainty-aware survival predictions for clinicians. • Validated on simulated & real-world survival datasets.

Human mobility plays a critical role in the transmission dynamics of infectious diseases, influencing both their spread and the effectiveness of control measures. In the process of quantifying the real-time situation of an epidemic, the instantaneous reproduction number Rt appears to be one of the useful metrics widely used by public health researchers, officials, and policy makers. Since individuals can contract infections both within their region of origin and in other regions they visit, ignoring human mobility in the estimation process overlooks its impact on transmission dynamics and can lead to biased estimates of Rt, potentially misrepresenting the true epidemic situation. Our study explicitly integrates human mobility into a renewal-equation based disease transmission model to capture the mobility-driven effect on transmission. By incorporating pathogen-specific generation-time distribution, observational delay, the framework is epidemiologically informed and flexible to a wide range of diseases. We primarily validate the approach using simulated data, and demonstrate the limitations of estimating Rt without considering mobility. We then apply it to two real-world mobility settings using SARS-CoV-2 mortality data: the regions of England and the LTLAs of North East region of England, and uncover the mobility driven effect on transmission at different spatial resolutions. This framework uses non-identifiable and widely accessible publicly available datasets, demonstrating its practical applicability and supporting better-informed and more targeted public health measures.

Updating observations of a signal due to the delays in the measurement process is a common problem in signal processing, with prominent examples in a wide range of fields. An important example of this problem is the nowcasting of COVID-19 mortality: given a stream of reported counts of daily deaths, can we correct for the delays in reporting to paint an accurate picture of the present, with uncertainty? Without this correction, raw data will often mislead by suggesting an improving situation. We present a flexible approach using a latent Gaussian process that is capable of describing the changing auto-correlation structure present in the reporting time-delay surface. This approach also yields robust estimates of uncertainty for the estimated nowcasted numbers of deaths. We test assumptions in model specification such as the choice of kernel or hyper priors, and evaluate model performance on a challenging real dataset from Brazil. Our experiments show that Gaussian process nowcasting performs favourably against both comparable methods, and against a small sample of expert human predictions. Our approach has substantial practical utility in disease modelling — by applying our approach to COVID-19 mortality data from Brazil, where reporting delays are large, we can make informative predictions on important epidemiological quantities such as the current effective reproduction number.

Developing new methods for modelling infectious diseases outbreaks is important for monitoring transmission and developing policy. In this paper we propose using semi-mechanistic Hawkes Processes for modelling malaria transmission in near-elimination settings. Hawkes Processes are well founded mathematical methods that enable us to combine the benefits of both statistical and mechanistic models to recreate and forecast disease transmission beyond just malaria outbreak scenarios. These methods have been successfully used in numerous applications such as social media and earthquake modelling, but are not yet widespread in epidemiology. By using domain-specific knowledge, we can both recreate transmission curves for malaria in China and Eswatini and disentangle the proportion of cases which are imported from those that are community based.

In order to monitor progress towards malaria elimination, it is crucial to be able to measure changes in spatio-temporal transmission. However, common metrics of malaria transmission such as parasite prevalence are under powered in elimination contexts. China has achieved major reductions in malaria incidence and is on track to eliminate, having reporting zero locally-acquired malaria cases in 2017 and 2018. Understanding the spatio-temporal pattern underlying this decline, especially the relationship between locally-acquired and imported cases, can inform efforts to maintain elimination and prevent re-emergence. This is particularly pertinent in Yunnan province, where the potential for local transmission is highest. Using a geo-located individual-level dataset of cases recorded in Yunnan province between 2011 and 2016, we introduce a novel Bayesian framework to model a latent diffusion process and estimate the joint likelihood of transmission between cases and the number of cases with unobserved sources of infection. This is used to estimate the case reproduction number, Rc. We use these estimates within spatio-temporal geostatistical models to map how transmission varied over time and space, estimate the timeline to elimination and the risk of resurgence. We estimate the mean Rc between 2011 and 2016 to be 0.171 (95% CI = 0.165, 0.178) for P. vivax cases and 0.089 (95% CI = 0.076, 0.103) for P. falciparum cases. From 2014 onwards, no cases were estimated to have a Rc value above one. An unobserved source of infection was estimated to be moderately likely (p>0.5) for 19/ 611 cases and high (p>0.8) for 2 cases, suggesting very high levels of case ascertainment. Our estimates suggest that, maintaining current intervention efforts, Yunnan is unlikely to experience sustained local transmission up to 2020. However, even with a mean of 0.005 projected up to 2020, locally-acquired cases are possible due to high levels of importation.

Understanding and predicting the popularity of online items is an important open problem in social media analysis. Most of the recent work on popularity prediction is either based on learning a variety of features from full network data or using generative processes to model the event time data. We identify two gaps in the current state of the art prediction models. The first is the unexplored connection and comparison between the two aforementioned approaches. In our work, we bridge gap between feature-driven and generative models by modelling social cascade with a marked Hawkes self-exciting point process. We then learn a predictive layer on top for popularity prediction using a collection of cascade history. Secondly, the existing methods typically focus on a single source of external influence, whereas for many types of online content such as YouTube videos or news articles, attention is driven by multiple heterogeneous sources simultaneously - e.g. microblogs or traditional media coverage. We propose a recurrent neural network based model for asynchronous streams that connects multiple streams of different granularity via joint inference. We further design two new measures, one to explain the viral potential of videos, the other to uncover latent influences including seasonal trends. This work provides accurate and explainable popularity predictions, as well as computational tools for content producers and marketers to allocate resources for promotion campaigns.

Among the statistical tools for online information diffusion modeling, both epidemic models and Hawkes point processes are popular choices. The former originate from epidemiology, and consider information as a viral contagion which spreads into a population of online users. The latter have roots in geophysics and finance, view individual actions as discrete events in continuous time, and modulate the rate of events according to the self-exciting nature of event sequences. Here, we establish a novel connection between these two frameworks. Namely, the rate of events in an extended Hawkes model is identical to the rate of new infections in the Susceptible-Infected-Recovered (SIR) model after marginalizing out recovery events -- which are unobserved in a Hawkes process. This result paves the way to apply tools developed for SIR to Hawkes, and vice versa. It also leads to HawkesN, a generalization of the Hawkes model which accounts for a finite population size. Finally, we derive the distribution of cascade sizes for HawkesN, inspired by methods in stochastic SIR. Such distributions provide nuanced explanations to the general unpredictability of popularity: the distribution for diffusion cascade sizes tends to have two modes, one corresponding to large cascade sizes and another one around zero.

Predicting popularity, or the total volume of information outbreaks, is an important subproblem for understanding collective behavior in networks. Each of the two main types of recent approaches to the problem, feature-driven and generative models, have desired qualities and clear limitations. This paper bridges the gap between these solutions with a new hybrid approach and a new performance benchmark. We model each social cascade with a marked Hawkes self-exciting point process, and estimate the content virality, memory decay, and user influence. We then learn a predictive layer for popularity prediction using a collection of cascade history. To our surprise, Hawkes process with a predictive overlay outperform recent feature-driven and generative approaches on existing tweet data [44] and a new public benchmark on news tweets. We also found that a basic set of user features and event time summary statistics performs competitively in both classification and regression tasks, and that adding point process information to the feature set further improves predictions. From these observations, we argue that future work on popularity prediction should compare across feature-driven and generative modeling approaches in both classification and regression tasks.

In topic modelling, various alternative priors have been developed, for instance asymmetric and symmetric priors for the document-topic and topic-word matrices respectively, the hierarchical Dirichlet process prior for the document-topic matrix and the hierarchical Pitman-Yor process prior for the topic-word matrix. For information retrieval, language models exhibiting word burstiness are important. Indeed, this burstiness effect has been show to help topic models as well, and this requires additional word probability vectors for each document. Here we show how to combine these ideas to develop high-performing non-parametric topic models exhibiting burstiness based on standard Gibbs sampling. Experiments are done to explore the behavior of the models under different conditions and to compare the algorithms with previously published. The full non-parametric topic models with burstiness are only a small factor slower than standard Gibbs sampling for LDA and require double the memory, making them very competitive. We look at the comparative behaviour of different models and present some experimental insights.