While the digitization of industrial factories provides tremendous improvements for the production of goods, it also renders such systems vulnerable to serious cyber-attacks. To research, test, and validate security measures protecting industrial networks against such cyber-attacks, the security community relies on testbeds to simulate industrial systems, as utilizing live systems endangers costly components or even human life. However, existing testbeds focus on individual parts of typically complex production lines in industrial factories. Consequently, the impact of cyber-attacks on industrial networks as well as the effectiveness of countermeasures cannot be evaluated in an end-to-end manner. To address this issue and facilitate research on novel security mechanisms, we present CoFacS, the first COmplete FACtory Simulation that replicates an entire production line and affords the integration of real-life industrial applications. To showcase that CoFacS accurately captures real-world behavior, we validate it against a physical model factory widely used in security research. We show that CoFacS has a maximum deviation of 0.11% to the physical reference, which enables us to study the impact of physical attacks or network-based cyber-attacks. Moreover, we highlight how CoFacS enables security research through two cases studies surrounding attack detection and the resilience of 5G-based industrial communication against jamming.

The industrial landscape is undergoing a significant transformation, moving away from traditional wired fieldbus networks to cutting-edge 5G mobile networks. This transition, extending from local applications to company-wide use and spanning multiple factories, is driven by the promise of low-latency communication and seamless connectivity for various devices in industrial settings. However, besides these tremendous benefits, the integration of 5G as the communication infrastructure in industrial networks introduces a new set of risks and threats to the security of industrial systems. The inherent complexity of 5G systems poses unique challenges for ensuring a secure integration, surpassing those encountered with any technology previously utilized in industrial networks. Most importantly, the distinct characteristics of industrial networks, such as real-time operation, required safety guarantees, and high availability requirements, further complicate this task. As the industrial transition from wired to wireless networks is a relatively new concept, a lack of guidance and recommendations on securely integrating 5G renders many industrial systems vulnerable and exposed to threats associated with 5G. To address this situation, in this paper, we summarize the state-of-the-art and derive a set of recommendations for the secure integration of 5G into industrial networks based on a thorough analysis of the research landscape. Furthermore, we identify opportunities to utilize 5G to enhance security and indicate remaining challenges, identifying future academic directions.

Deep generative models can be trained to represent the joint distribution of data, such as measurements of single nucleotide polymorphisms (SNPs) from several individuals. Subsequently, synthetic observations are obtained by drawing from this distribution. This has been shown to be useful for several tasks, such as removal of noise, imputation, for better understanding underlying patterns, or even exchanging data under privacy constraints. Yet, it is still unclear how well these approaches work with limited sample size. We investigate such settings specifically for binary data, e.g. as relevant when considering SNP measurements, and evaluate three frequently employed generative modeling approaches, variational autoencoders (VAEs), deep Boltzmann machines (DBMs) and generative adversarial networks (GANs). This includes conditional approaches, such as when considering gene expression conditional on SNPs. Recovery of pair-wise odds ratios (ORs) is considered as a primary performance criterion. For simulated as well as real SNP data, we observe that DBMs generally can recover structure for up to 300 variables, with a tendency of over-estimating ORs when not carefully tuned. VAEs generally get the direction and relative strength of pairwise relations right, yet with considerable under-estimation of ORs. GANs provide stable results only with larger sample sizes and strong pair-wise relations in the data. Taken together, DBMs and VAEs (in contrast to GANs) appear to be well suited for binary omics data, even at rather small sample sizes. This opens the way for many potential applications where synthetic observations from omics data might be useful.

MOTIVATION: Learning the joint distributions of measurements, and in particular identification of an appropriate low-dimensional manifold, has been found to be a powerful ingredient of deep leaning approaches. Yet, such approaches have hardly been applied to single nucleotide polymorphism (SNP) data, probably due to the high number of features typically exceeding the number of studied individuals. RESULTS: After a brief overview of how deep Boltzmann machines (DBMs), a deep learning approach, can be adapted to SNP data in principle, we specifically present a way to alleviate the dimensionality problem by partitioned learning. We propose a sparse regression approach to coarsely screen the joint distribution of SNPs, followed by training several DBMs on SNP partitions that were identified by the screening. Aggregate features representing SNP patterns and the corresponding SNPs are extracted from the DBMs by a combination of statistical tests and sparse regression. In simulated case-control data, we show how this can uncover complex SNP patterns and augment results from univariate approaches, while maintaining type 1 error control. Time-to-event endpoints are considered in an application with acute myeloid leukemia patients, where SNP patterns are modeled after a pre-screening based on gene expression data. The proposed approach identified three SNPs that seem to jointly influence survival in a validation dataset. This indicates the added value of jointly investigating SNPs compared to standard univariate analyses and makes partitioned learning of DBMs an interesting complementary approach when analyzing SNP data. AVAILABILITY AND IMPLEMENTATION: A Julia package is provided at 'http://github.com/binderh/BoltzmannMachines.jl'. CONTACT: [email protected]. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.