This work exploits Riemannian manifolds to introduce a geometric framework for online state and community classification in dynamic multilayer networks where nodes are annotated with time series. A bottom-up approach is followed, starting from the extraction of Riemannian features from nodal time series, and reaching up to on- line/sequential classification of features via geodesic distances and angular information in the tangent spaces of a Riemannian manifold. As a case study, features in the Grassmann manifold are generated by fitting a kernel autoregressive-moving-average model to the nodal time series of the multilayer network. The paper highlights also numerical tests on synthetic and real brain-network data, where it is shown that the proposed geometric framework outperforms state-of- the-art deep-learning models in classification accuracy, especially in cases where the number of training data is small with respect to the number of the testing ones.

Modern neuroimaging techniques offer disctinct views on brain structure and function. Data acquired using these techniques can be analyzed in terms of its network structure to identify organizing principles at the systems level. Graph representations are flexible frameworks where nodes are related to brain regions and edges to structural or functional links. Most research to date has focused on analyzing these graphs reflecting structure or function. Graph signal processing (GSP) is an emerging area of research where signals at the nodes are studied atop the underlying graph structure. Here, we review GSP tools for brain imaging data and discuss their potential to integrate brain structure with function. We discuss how brain activity can be meaningfully filtered. We also derive surrogate data as a null model to test significance for graph signals. We review that individuals with less concentration on graph high frequency could switch attention faster.

Modern neuroimaging techniques provide us with unique views on brain structure and function; i.e., how the brain is wired, and where and when activity takes place. Data acquired using these techniques can be analyzed in terms of its network structure to reveal organizing principles at the systems level. Graph representations are versatile models where nodes are associated to brain regions and edges to structural or functional connections. Structural graphs model neural pathways in white matter, which are the anatomical backbone between regions. Functional graphs are built based on functional connectivity, which is a pairwise measure of statistical interdependency between pairs of regional activity traces. Therefore, most research to date has focused on analyzing these graphs reflecting structure or function. Graph signal processing (GSP) is an emerging area of research where signals recorded at the nodes of the graph are studied atop the underlying graph structure. An increasing number of fundamental operations have been generalized to the graph setting, allowing to analyze the signals from a new viewpoint. Here, we review GSP for brain imaging data and discuss their potential to integrate brain structure, contained in the graph itself, with brain function, residing in the graph signals. We review how brain activity can be meaningfully filtered based on concepts of spectral modes derived from brain structure. We also derive other operations such as surrogate data generation or decompositions informed by cognitive systems. In sum, GSP offers a novel framework for the analysis of brain imaging data.

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of anatomical brain organization on human task performance, we use a data-driven computational modeling approach and explore the functional effects of naturally occurring structural differences in brain networks. We construct personalized brain network models by combining anatomical connectivity estimated from diffusion spectrum imaging of individual subjects with a nonlinear model of brain dynamics. By performing computational experiments in which we measure the excitability of the global brain network and spread of synchronization following a targeted computational stimulation, we quantify how individual variation in the underlying connectivity impacts both local and global brain dynamics. We further relate the computational results to individual variability in the subjects' performance of three language-demanding tasks both before and after transcranial magnetic stimulation to the left-inferior frontal gyrus. Our results show that task performance correlates with either local or global measures of functional activity, depending on the complexity of the task. By emphasizing differences in the underlying structural connectivity, our model serves as a powerful tool to assess individual differences in task performances, to dissociate the effect of targeted stimulation in tasks that differ in cognitive demand, and to pave the way for the development of personalized therapeutics.

Brain anatomy and physiology support the human ability to navigate a complex space of perceptions and actions. To maneuver across an ever-changing landscape of mental states, the brain invokes cognitive control-a set of dynamic processes that engage and disengage different groups of brain regions to modulate attention, switch between tasks, and inhibit prepotent responses. Current theory posits that correlated and anticorrelated brain activity may signify cooperative and competitive interactions between brain areas that subserve adaptive behavior. In this study, we use a quantitative approach to identify distinct topological motifs of functional interactions and examine how their expression relates to cognitive control processes and behavior. In particular, we acquire fMRI BOLD signal in twenty-eight healthy subjects as they perform two cognitive control tasks-a Stroop interference task and a local-global perception switching task using Navon figures-each with low and high cognitive control demand conditions. Based on these data, we construct dynamic functional brain networks and use a parts-based, network decomposition technique called non-negative matrix factorization to identify putative cognitive control subgraphs whose temporal expression captures distributed network structures involved in different phases of cooperative and competitive control processes. Our results demonstrate that temporal expression of the subgraphs fluctuate alongside changes in cognitive demand and are associated with individual differences in task performance. These findings offer insight into how coordinated changes in the cooperative and competitive roles of cognitive systems map trajectories between cognitively demanding brain states.

[This corrects the article DOI: 10.1371/journal.pcbi.1006234.].