For a data-generating process for random variables that can be described with a linear structural equation model, we consider a situation in which (i) a set of covariates satisfying the back-door criterion cannot be observed or (ii) such a set can be observed, but standard statistical estimation methods cannot be applied to estimate causal effects because of multicollinearity/high-dimensional data problems. We propose a novel two-stage penalized regression approach, the penalized covariate-mediator selection operator (PCM Selector), to estimate the causal effects in such scenarios. Unlike existing penalized regression analyses, when a set of intermediate variables is available, PCM Selector provides a consistent or less biased estimator of the causal effect. In addition, PCM Selector provides a variable selection procedure for intermediate variables to obtain better estimation accuracy of the causal effects than does the back-door criterion.

In this paper, we deal with the evaluation problem of "causes of effects" (CoE), which focuses on the likelihood that one event was the cause of another. To assess this likelihood, three types of probabilities of causation have been utilized: probability of necessity, probability of sufficiency, and probability of necessity and sufficiency. However, these usually cannot be estimated, even if "effects of causes" (EoC) is estimable from statistical data, regardless of how large the data is. To solve this problem, we propose novel identification conditions for CoE, using an intermediate variable together with covariate information. Additionally, we also propose a new method for estimating CoE that is applicable whenever they are identifiable through the proposed identification conditions.

*Probabilities of causation* (PoC) are valuable concepts for explainable artificial intelligence and practical decision-making. PoC are originally defined for scalar binary variables. In this paper, we extend the concept of PoC to continuous treatment and outcome variables, and further generalize PoC to capture causal effects between multiple treatments and multiple outcomes. In addition, we consider PoC for a sub-population and PoC with multi-hypothetical terms to capture more sophisticated counterfactual information useful for decision-making. We provide a nonparametric identification theorem for each type of PoC we introduce. Finally, we illustrate the application of our results on a real-world dataset about education.

There has been considerable recent interest in estimating heterogeneous causal effects. In this paper, we study conditional average partial causal effects (CAPCE) to reveal the heterogeneity of causal effects with continuous treatment. We provide conditions for identifying CAPCE in an instrumental variable setting. Notably, CAPCE is identifiable under a weaker assumption than required by a commonly used measure for estimating heterogeneous causal effects of continuous treatment. We develop three families of CAPCE estimators: sieve, parametric, and reproducing kernel Hilbert space (RKHS)-based, and analyze their statistical properties. We illustrate the proposed CAPCE estimators on synthetic and real-world data.

We propose novel identification conditions and a statistical estimation method for the probabilities of potential outcome types using covariate information in randomized trials in which the treatment assignment is randomized but subject compliance is not perfect. Different from existing studies, the proposed identification conditions do not require strict assumptions such as the assumption of monotonicity. When the probabilities of potential outcome types are identifiable through the proposed conditions, the problem of estimating the probabilities of potential outcome types is reduced to that of singular models. Thus, the probabilities cannot be evaluated using standard statistical likelihood-based estimation methods. Rather, the proposed identification conditions show that we can derive consistent estimators of the probabilities of potential outcome types via the method of moments, which leads to the asymptotic normality of the proposed estimators through the delta method under regular conditions. We also propose a new statistical estimation method based on the bounded constrained augmented Lagrangian method to derive more efficient estimators than can be derived through the method of moments.

The concept of potential outcome types is one of the fundamental components of causal inference. However, even in randomized experiments, assumptions on the data generating process, such as monotonicity, are required to evaluate the probabilities of the potential outcome types. To solve the problem without such assumptions in experimental studies, a novel identification condition based on proxy covariate information is proposed in this paper. In addition, the estimation problem of the probabilities of the potential outcome types reduces to that of singular models when they are identifiable through the proposed condition. Thus, they cannot be evaluated by standard statistical estimation methods. To overcome this difficulty, new plug-in estimators of these probabilities are presented, and the asymptotic normality of the proposed estimators is shown.

Instrumental variable (IV) analysis is a powerful tool widely used to elucidate causal relationships. We study the problem of estimating the average partial causal effect (APCE) of a continuous treatment in an IV setting. Specifically, we develop new methods for estimating APCE based on a recent identification condition via an integral equation. We develop two families of methods, nonparametric and parametric - the former uses the Picard iteration to solve the integral equation; the latter parameterizes APCE using a linear basis function model. We analyze the statistical and computational properties of the proposed methods and illustrate them on synthetic and real data.

This paper assumes that cause-effect relationships among variables can be described with a linear structural equation model. Then, a situation is considered where a set of observed covariates satisfies the back-door criterion but the ordinary least squares method cannot be applied to estimate linear causal effects because of multicollinearity/high-dimensional data problems. In this situation, we propose a novel regression approach, the “partially adaptive L$_p$-regularized multiple regression analysis” (PAL$_p$MA) method for estimating the total effects. Different from standard regularized regression analysis, PAL$_p$MA provides a consistent or less-biased estimator of the linear causal effect. PAL$_p$MA is also applicable to evaluating direct effects through the single-door criterion. Given space constraints, the proofs, some numerical experiments, and an industrial case study on setting up painting conditions of car bodies are provided in the Supplementary Material.

The joint probabilities of potential outcomes are fundamental components of causal inference in the sense that (i) if they are identifiable, then the causal risk is also identifiable, but not vise versa (Pearl, 2009; Tian and Pearl, 2000) and (ii) they enable us to evaluate the probabilistic aspects of necessity'',sufficiency'', and ``necessity and sufficiency'', which are important concepts of successful explanation (Watson, et al., 2020). However, because they are not identifiable without any assumptions, various assumptions have been utilized to evaluate the joint probabilities of potential outcomes, e.g., the assumption of monotonicity (Pearl, 2009; Tian and Pearl, 2000), the independence between potential outcomes (Robins and Richardson, 2011), the condition of gain equality (Li and Pearl, 2019), and the specific functional relationships between cause and effect (Pearl, 2009). Unlike existing identification conditions, in order to evaluate the joint probabilities of potential outcomes without such assumptions, this paper proposes two types of novel identification conditions using covariate information. In addition, when the joint probabilities of potential outcomes are identifiable through the proposed conditions, the estimation problem of the joint probabilities of potential outcomes reduces to that of singular models and thus they can not be evaluated by standard statistical estimation methods. To solve the problem, this paper proposes a new statistical estimation method based on the augmented Lagrangian method and shows the asymptotic normality of the proposed estimators. Given space constraints, the proofs, the details on the statistical estimation method, some numerical experiments, and the case study are provided in the supplementary material.

This paper considers the problem of estimating causal effects of a treatment on a response using supplementary variables. Under the assumption that a treatment is associated with a response through a univariate supplementary variable in the framework of linear regression models, Cox (1960) showed that the estimation accuracy of the regression coefficient of the treatment on the response in the single linear regression model can be improved by using the recursive linear regression model based on the supplementary variable from the viewpoint of the asymptotic variance. However, such assumptions may not hold in many practical situations. In this paper, we consider the situation where a treatment is associated with a response through a set of supplementary variables in both linear and discrete models. Then, we show that the estimation accuracy of the causal effect can be improved by using the supplementary variables. Different from Cox (1960), the results of this paper are derived without the assumption of Gaussian error terms in linear models or dichotomous variables in discrete models. The results of this paper help us to obtain the reliable evaluation of causal effects from observed data.