MRI has become essential in clinical diagnosis due to its high resolution and multiple contrast mechanisms. However, the relatively long acquisition time limits its broader application. To address this issue, this study presents an innovative conditional guided diffusion model, named TC-KANRecon, which incorporates the Multi-Free U-KAN module and a dynamic clipping strategy. TC-KANRecon model aims to accelerate the MRI reconstruction process through deep learning methods while maintaining the reconstruction quality. The MF-UKAN module can effectively balance the tradeoff between image denoising and structure preservation. Specifically, it presents the multi-head attention mechanisms and scalar modulation factors, which significantly enhance the model's robustness and structure preservation capabilities in complex noise environments. Moreover, the dynamic clipping strategy in TC-KANRecon adjusts the cropping interval according to the sampling steps, thereby mitigating image detail loss while preserving the visual features of the images. Furthermore, the Conditional Guidance Model incorporates full-sampling k-space information, realizing efficient fusion of conditional information, enhancing the model's ability to process complex data, and improving the realism and detail richness of reconstructed images. Experimental results demonstrate that the proposed method outperforms other MRI reconstruction methods in both qualitative and quantitative evaluations. Notably, TC-KANRecon method exhibits excellent reconstruction results when processing high-noise, low-sampling-rate MRI data.

Brain tumor segmentation from low-quality MRI scans poses significant challenges, particularly in sub-Saharan Africa, where the scans frequently suffer from low resolution and artifacts. Such degradations introduce substantial domain shifts that hinder the effectiveness of existing test-time adaptation (TTA) methods, largely due to catastrophic forgetting and the unreliability of pseudo-labels. In response, we introduce DRTTA, a dynamic and robust framework designed for effective test-time adaptation. This method maintains essential knowledge from the source domain by freezing certain parameters and utilizing adaptive BatchNorm, allowing for successful alignment with the target domain. During inference, DR-TTA employs a learnable augmentation strategy that is optimized to simulate distortions specific to the target domain. Additionally, a hybrid loss function incorporating geometric constraints is used to filter out unreliable pseudo-labels, thus stabilizing the training process. Our extensive experiments on the BraTS-SSA and BraTS-SIM datasets demonstrate that DR-TTA significantly surpasses existing state-of-the-art methods across key performance metrics. This advancement provides a viable solution for deploying brain tumor segmentation technology in real-world scenarios, particularly within resource-limited environments. Our source code is available at https://github.com/baiyou1234/DR-TTA.

Alzheimer’s Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to misdiagnosis with traditional unimodal diagnostic methods due to their limited scope. This study introduces an advanced multimodal classification model that integrates clinical, cognitive, neuroimaging, and EEG data to enhance diagnostic accuracy. The model incorporates a feature tagger with a tabular data coding architecture and utilizes the TimesBlock module to capture intricate temporal patterns in Electroencephalograms (EEG) data. By employing Cross-modal Attention Aggregation module, the model effectively fuses Magnetic Resonance Imaging (MRI) spatial information with EEG temporal data, significantly improving the distinction between AD, Mild Cognitive Impairment, and Normal Cognition. Simultaneously, we have constructed the first AD classification dataset that includes three modalities: EEG, MRI, and tabular data. Our innovative approach aims to facilitate early diagnosis and intervention, potentially slowing the progression of AD. The source code and our private ADMC dataset are available at https://github.com/JustlfC03/MSTNet.

The incidence and mortality rates of malignant tumors, such as acute leukemia, have risen significantly. Clinically, hospitals rely on cytological examination of peripheral blood and bone marrow smears to diagnose malignant tumors, with accurate blood cell counting being crucial. Existing automated methods face challenges such as low feature expression capability, poor interpretability, and redundant feature extraction when processing high-dimensional microimage data. We propose a novel fine-grained classification model, SCKansformer, for bone marrow blood cells, which addresses these challenges and enhances classification accuracy and efficiency. The model integrates the Kansformer Encoder, SCConv Encoder, and Global-Local Attention Encoder. The Kansformer Encoder replaces the traditional MLP layer with the KAN, improving nonlinear feature representation and interpretability. The SCConv Encoder, with its Spatial and Channel Reconstruction Units, enhances feature representation and reduces redundancy. The Global-Local Attention Encoder combines Multi-head Self-Attention with a Local Part module to capture both global and local features. We validated our model using the Bone Marrow Blood Cell Fine-Grained Classification Dataset (BMCD-FGCD), comprising over 10,000 samples and nearly 40 classifications, developed with a partner hospital. Comparative experiments on our private dataset, as well as the publicly available PBC and ALL-IDB datasets, demonstrate that SCKansformer outperforms both typical and advanced microcell classification methods across all datasets.