Due to the diversity of brain anatomy and the scarcity of annotated data, supervised anomaly detection for brain MRI remains challenging, driving the development of unsupervised anomaly detection (UAD) approaches. Current UAD methods typically utilize synthetically generated noise perturbations on healthy MRIs to train generative models for normal anatomy reconstruction, enabling anomaly detection via residual maps. However, such simulated anomalies lack the biophysical fidelity and morphological complexity characteristic of true clinical lesions. To advance UAD in brain MRI, we conduct the first systematic frequency-domain analysis of pathological signatures, revealing two key properties: (1) anomalies exhibit unique frequency patterns distinguishable from normal anatomy, and (2) low-frequency signals maintain consistent representations across healthy scans. These insights motivate our Frequency-Decomposition Preprocessing (FDP) framework—the first UAD method to leverage frequency-domain reconstruction for simultaneous pathology suppression and anatomical preservation. FDP can integrate seamlessly with existing anomaly simulation techniques, consistently enhancing detection performance across diverse architectures while maintaining diagnostic fidelity. Experimental results demonstrate that FDP consistently improves anomaly detection performance when integrated with existing methods. Notably, FDP achieves a 17.63% increase in DICE score with LDM while maintaining robust improvements across multiple baselines.

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable effective modeling. A key challenge is that pathological tasks typically provide only bag-level labels, while instance-level descriptions generated by LLMs often suffer from bias due to a lack of fine-grained medical knowledge. To address this, we propose that constructing task-specific pathological entity prototypes is crucial for learning generalizable features and enhancing model interpretability. Furthermore, existing vision-language MIL methods often employ unidirectional guidance, limiting cross-modal synergy. In this paper, we introduce a novel approach, Multimodal Prototype-based Multi-Instance Learning, that promotes bidirectional interaction through a balanced information compression scheme. Specifically, we leverage a frozen LLM to generate task-specific pathological entity descriptions, which are learned as text prototypes. Concurrently, the vision branch learns instance-level prototypes to mitigate the model's reliance on redundant data. For the fusion stage, we employ the Stereoscopic Optimal Transport (SOT) algorithm, which is based on a similarity metric, thereby facilitating broader semantic alignment in a higher-dimensional space. We conduct few-shot classification and explainability experiments on three distinct cancer datasets, and the results demonstrate the superior generalization capabilities of our proposed method.

Significant disparities between the features of natural images and those inherent to histopathological images make it challenging to directly apply and transfer pre-trained models from natural images to histopathology tasks. Moreover, the frequent lack of annotations in histopathology patch images has driven researchers to explore self-supervised learning methods like mask reconstruction for learning representations from large amounts of unlabeled data. Crucially, previous mask-based efforts in self-supervised learning have often overlooked the spatial interactions among entities, which are essential for constructing accurate representations of pathological entities. To address these challenges, constructing graphs of entities is a promising approach. In addition, the diffusion reconstruction strategy has recently shown superior performance through its random intensity noise addition technique to enhance the robust learned representation. Therefore, we introduce H-MGDM, a novel self-supervised Histopathology image representation learning method through the Dynamic Entity-Masked Graph Diffusion Model. Specifically, we propose to use complementary subgraphs as latent diffusion conditions and self-supervised targets respectively during pre-training. We note that the graph can embed entities' topological relationships and enhance representation. Dynamic conditions and targets can improve pathological fine reconstruction. Our model has conducted pretraining experiments on three large histopathological datasets. The advanced predictive performance and interpretability of H-MGDM are clearly evaluated on comprehensive downstream tasks such as classification and survival analysis on six datasets.

International audience

Multiple instance learning is an effective paradigm for whole slide image (WSI) classification, where labels are only provided at the bag level. However, instance-level prediction is also crucial as it offers insights into fine-grained regions of interest. Existing multiple instance learning methods either solely focus on training a bag classifier or have the insufficient capability of exploring instance prediction. In this work, we propose a novel model-agnostic framework to boost existing multiple instance learning models, to improve the WSI classification performance in both bag and instance levels. Specifically, we propose a counterfactual inference-based sub-bag assessment method and a hierarchical instance searching strategy to help to search reliable instances and obtain their accurate pseudo labels. Furthermore, an instance classifier is well-trained to produce accurate predictions. The instance embedding it generates is treated as a prompt to refine the instance feature for bag prediction. This framework is model-agnostic, capable of adapting to existing multiple instance learning models, including those without specific mechanisms like attention. Extensive experiments on three datasets demonstrate the competitive performance of our method. Code will be available at https://github.com/centurion-crawler/CIMIL.

A glasses-free 3D display that tracks the observer position over a large viewing area is described in this paper. The head position tracking algorithm is employed to provide regions referred to as exit pupils to viewer's eyes. A head tracker controlling an LCD backlight has been specially designed. The backlight follows the position of the observer's eyes so that left and right images can be seen appropriately.

In this paper, we propose a method to optimize two-layer light field display using depth initialization. In contrast to existing trade-off work between performance and processing time, this paper firstly models the display principle of layered light field display, and then performs layered initialization with the prior known depth of 3D objects, and finally optimizes the layered images for light field display. Experiments demonstrate that the proposed initialization method can obviously save the iterations and related processing time for the existing online or offline algorithms to achieve the same reconstructed peak signal to noise ratio (PSNR) and present a better subjective reconstructed performance using the same computation resource.

Two displays that enable the formation of floating images in the air are proposed. A high-refresh-rate monitor and two Fresnel lenses are used in the first demo system to create the real image in the air. The second demo system is composed of a slanted lenticular sheet and multiple semi-transparent mirrors. The floating 3D image can be observed by multiple users simultaneously. The principle and performance of the proposed displays are analyzed in this paper. Two prototypes of the viewable floating displays have been built. The results indicate that the displays are a feasible means of producing the illusion of images with depth.