Cloud detection plays a major role for remote sensing image processing. Most of the existed cloud detection methods use the low-level feature of the cloud, which often cause error result especially for thin cloud and complex scene. In this paper, a novel cloud detection method based on deep learning framework is proposed. The designed deep Convolutional Neural Networks (CNNs) consists of four convolutional layers and two fully-connected layers, which can mine the deep features of cloud. The image is firstly clustered into superpixels as sub-region through simple linear iterative cluster (SLIC) method. Through the designed network model, the probability of each superpixel that belongs to cloud region is predicted, so that the cloud probability map of the image is generated. Lastly, the cloud region is obtained according to the gradient of the cloud map. Through the proposed method, both thin cloud and thick cloud can be detected well, and the result is insensitive to complex scene. Experimental results indicate that the proposed method is more robust and effective than compared methods.