Abstract Summary: Endeavour is a tool that detects the most promising genes within large lists of candidates with respect to a biological process of interest and by combining several genomic data sources. We have benchmarked Endeavour using 450 pathway maps and 826 disease marker sets from MetaCoreTM of GeneGo, Inc. containing a total of 9911 and 12 432 genes, respectively. We obtained an area under the receiver operating characteristic curves of 0.97 for pathway and of 0.91 for disease gene sets. These results indicate that Endeavour can be used to efficiently prioritize candidate genes for pathways and diseases. Availability: Endeavour is available at http://www.esat.kuleuven.be/endeavour Contact: [email protected]; [email protected] Supplementary information: Supplementary data are available at Bioinformatics online.

Abstract Summary: The 3Dee database is a repository of protein structural domains. It stores alternative domain definitions for the same protein, organises domains into sequence and structural hierarchies, contains non-redundant set(s) of sequences and structures, multiple structure alignments for families of domains, and allows previous versions of the database to be regenerated. Availability: 3Dee is accessible on the World Wide Web at the URL http://barton.ebi.ac.uk/servers/3Dee.html Contact: [email protected]; http://barton.ebi.ac.uk * To whom correspondence should be addressed. Present address: EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.