With the rapid development of e-health technology and artificial intelligence, healthcare services have undergone significant digitalization and intelligence transformation. This drives the emergence of innovative models such as personalized care and telemedicine, making electronic medical information sharing a critical research focus. However, due to the high sensitivity of medical data, existing sharing platforms face challenges, including insufficient privacy protection, inadequate guarantees of data integrity and authenticity, and reliance on centralized systems. These issues can lead to risks including identity information leakage, data tampering, and single points of failure. To address these challenges, this paper proposes a blockchain-based framework for electronic medical information sharing, namely PCTRS, which stands for Privacy and Control in Electronic Medical Records through Blockchain and Threshold Traceable Ring Signatures. The framework integrates InterPlanetary File System for off-chain storage, reducing costs while enhancing data security through Elliptic Curve Diffie–Hellman Ephemeral key exchange and Advanced Encryption Standard – Galois/Counter Mode encryption. By integrating smart contracts with a threshold-based traceable ring signature scheme, the system achieves an optimal balance between privacy protection and transparency. Furthermore, the system implements a reputation mechanism combined with decentralized arbitration to ensure reliability, effectively mitigating security risks in medical data sharing.

MOTIVATION: Exploring the potential long noncoding RNA (lncRNA)-disease associations (LDAs) plays a critical role for understanding disease etiology and pathogenesis. Given the high cost of biological experiments, developing a computational method is a practical necessity to effectively accelerate experimental screening process of candidate LDAs. However, under the high sparsity of LDA dataset, many computational models hardly exploit enough knowledge to learn comprehensive patterns of node representations. Moreover, although the metapath-based GNN has been recently introduced into LDA prediction, it discards intermediate nodes along the meta-path and results in information loss. RESULTS: This paper presents a new multi-view contrastive heterogeneous graph attention network (GAT) for lncRNA-disease association prediction, MCHNLDA for brevity. Specifically, MCHNLDA firstly leverages rich biological data sources of lncRNA, gene and disease to construct two-view graphs, feature structural graph of feature schema view and lncRNA-gene-disease heterogeneous graph of network topology view. Then, we design a cross-contrastive learning task to collaboratively guide graph embeddings of the two views without relying on any labels. In this way, we can pull closer the nodes of similar features and network topology, and push other nodes away. Furthermore, we propose a heterogeneous contextual GAT, where long short-term memory network is incorporated into attention mechanism to effectively capture sequential structure information along the meta-path. Extensive experimental comparisons against several state-of-the-art methods show the effectiveness of proposed framework.The code and data of proposed framework is freely available at https://github.com/zhaoxs686/MCHNLDA.

The diversified top-k weight clique (DTKWC) search problem is an important generalization of the diversified top-k clique search problem, which extends the DTKC search problem by taking into account the weight of vertices. This problem involves finding at most k maximal weighted cliques that cover maximum weight of vertices with low overlapping in a given graph. In this study, a mixed integer linear program constraint formulation is proposed to model DTKWC search problem and an efficient hybrid evolutionary algorithm (HEA-D) based on some heuristic strategies is proposed to tackle it. Experiments on two sets of 110 graphs show that HEA-D outperforms the state-of-art methods.

The diversified top-k weight clique (DTKWC) search problem is an important generalization of the diversified top-k clique (DTKC) search problem with extensive applications, which extends the DTKC search problem by taking into account the weight of vertices. In this paper, we formulate DTKWC search problem using mixed integer linear program constraints and propose an efficient hybrid evolutionary algorithm (HEA-D) that combines a clique-based crossover operator and an effective simulated annealing-based local optimization procedure to find high-quality local optima. The experimental results show that HEA-D performs much better than the existing methods on two representative real-world benchmarks.

The diversified top-k s-plex (DTKSP) search problem aims to find k maximal s-plexes that cover the maximum number of vertices with lower overlapping in a given graph. In this paper, we first formalize the diversified top-k s-plex search problem and prove the NP-hardness of it. Second, we proposed a local search algorithm for solving the diversified top-k s-plex search problem based on some novel ideas. Experiments on real-world massive graphs show the effectiveness of our algorithm.