The process of new drug development is complex, whereas drug-disease association (DDA) prediction aims to identify new therapeutic uses for existing medications. However, existing graph contrastive learning approaches typically rely on single-view contrastive learning, which struggle to fully capture drug-disease relationships. Subsequently, we introduce a novel multi-view contrastive learning framework, named CDPMF-DDA, which enhances the model's ability to capture drug-disease associations by incorporating diverse information representations from different views. First, we decompose the original drug-disease association matrix into drug and disease feature matrices, which are then used to reconstruct the drug-disease association network, as well as the drug-drug and disease-disease similarity networks. This process effectively reduces noise in the data, establishing a reliable foundation for the networks produced. Next, we generate multiple contrastive views from both the original and generated networks. These views effectively capture hidden feature associations, significantly enhancing the model's ability to represent complex relationships. Extensive cross-validation experiments on three standard datasets show that CDPMF-DDA achieves an average AUC of 0.9475 and an AUPR of 0.5009, outperforming existing models. Additionally, case studies on Alzheimer's disease and epilepsy further validate the model's effectiveness, demonstrating its high accuracy and robustness in drug-disease association prediction. Based on a multi-view contrastive learning framework, CDPMF-DDA is capable of integrating multi-source information and effectively capturing complex drug-disease associations, making it a powerful tool for drug repositioning and the discovery of new therapeutic strategies.

Real-time nonlinear multimode process monitoring of actual industrial systems has attracted increasing attention recently. In this article, the time-weighed kernel sparse representation (TWKSR) method is proposed to partition the mode of the training dataset by introducing the time-series-dependent characteristics into the kernel sparse representation algorithm. The alternating direction method of multipliers is utilized to solve the optimization problem of the proposed TWKSR method. Then, the representative samples from each identified mode are selected to update the dictionary matrix. Based on the updated dictionary matrix, the sparse coefficient is used for online mode identification, and the reconstruction error is utilized for fault detection. Finally, a numerical simulation case and the wastewater treatment process example verify the effectiveness of the proposed method.

The multi-hop protocols are proved effective in the railway disaster wireless monitoring system. However, farther transmission distance with the larger data will decline the valid lifetime and reliability of the system. Most existing studies focused primarily on the communication protocols optimization, and some works tried to utilize the limited computation ability at the network-level or node-level, which are insufficient for the stiff disaster information monitoring demands. This paper presents an adaptive hybrid computation and communication strategy to fully taking advantage of the sensor processing ability, and improve the energy efficiency at the link-level. Furthermore, an adaptive optimization model is designed to meet the different monitoring demands of the system, and the valid lifetime is improved accordingly. Numerical examples with various operational scenarios are developed to demonstrate the superiority and practicality of the proposed protocol in the lifetime improvement, energy consumption minimization and equalization compared with other outstanding protocols.

Energy efficiency of wireless sensors is critical to maintaining the function of the monitoring system. Generally, the energy consumed in data transmission is much larger than in compression. Hence, decreasing data packet size with the aid of data compression before transmission can facilitate the reduction of energy consumption in communication. However, the energy consumed in data computation is also considerable, and improper computation ways may incur more energy consumption. To address this issue, in this article, two-hierarchy communication and computation hybrid optimization protocol is presented to minimize the total energy consumption. First, the cluster heads (CHs) rotation and clusters updating strategies are proposed in the communication layer, and the optimized adaptive compression ratios for the CHs are adopted in the computation layer. The hybrid optimization scheme is performed from the views of communication and computation synergistically to improve energy efficiency. The simulation results show the superiority of the proposed protocol compared with other outstanding protocols.