In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is crucial in resolving near-atomic resolution 3D structures of proteins, such as the SARS-COV-2 spike protein. To achieve high-resolution reconstruction, a comprehensive data processing pipeline has been adopted. However, its performance is still limited as it lacks high-quality annotated datasets for training. To address this, we introduce physics-informed generative cryo-electron microscopy (CryoGEM), which for the first time integrates physics-based cryo-EM simulation with a generative unpaired noise translation to generate physically correct synthetic cryo-EM datasets with realistic noises. Initially, CryoGEM simulates the cryo-EM imaging process based on a virtual specimen. To generate realistic noises, we leverage an unpaired noise translation via contrastive learning with a novel mask-guided sampling scheme. Extensive experiments show that CryoGEM is capable of generating authentic cryo-EM images. The generated dataset can be used as training data for particle picking and pose estimation models, eventually improving the reconstruction resolution.

Nowadays, time-sync comment (TSC), a new form of interactive comments, has become increasingly popular on Chinese video websites. By posting TSCs, people can easily express their feelings and exchange their opinions with others when watching online videos. However, some spoilers appear among the TSCs. These spoilers reveal crucial plots in videos that ruin people's surprise when they first watch the video. In this paper, we proposed a novel Similarity-Based Network with Interactive Variance Attention (SBN-IVA) to classify comments as spoilers or not. In this framework, we firstly extract textual features of TSCs through the word-level attentive encoder. We design Similarity-Based Network (SBN) to acquire neighbor and keyframe similarity according to semantic similarity and timestamps of TSCs. Then, we implement Interactive Variance Attention (IVA) to eliminate the impact of noise comments. Finally, we obtain the likelihood of spoiler based on the difference between the neighbor and keyframe similarity. Experiments show SBN-IVA is on average 11.2% higher than the state-of-the-art method on F1-score in baselines.

Time-sync comment (TSC) is a new form of user-interaction review associated with real-time video contents, which contains a user's preferences for videos and therefore well suited as the data source for video recommendations. However, existing review-based recommendation methods ignore the context-dependent (generated by user-interaction), real-time, and time-sensitive properties of TSC data. To bridge the above gaps, in this paper, we use video images and users' TSCs to design an Image-Text Fusion model with a novel Herding Effect Attention mechanism (called ITF-HEA), which can predict users' favorite videos with model-based collaborative filtering. Specifically, in the HEA mechanism, we weight the context information based on the semantic similarities and time intervals between each TSC and its context, thereby considering influences of the herding effect in the model. Experiments show that ITF-HEA is on average 3.78% higher than the state-of-the-art method upon F1-score in baselines.

Time-sync comments (TSCs) reveal a new way of extracting the online video tags. However, such TSCs have lots of noises due to users’ diverse comments, introducing great challenges for accurate and fast video tag extractions. In this article, we propose an unsupervised video tag extraction algorithm named Semantic Weight-Inverse Document Frequency (SW-IDF). Specifically, we first generate corresponding semantic association graph (SAG) using semantic similarities and timestamps of the TSCs. Second, we propose two graph cluster algorithms, i.e., dialogue-based algorithm and topic center-based algorithm, to deal with the videos with different density of comments. Third, we design a graph iteration algorithm to assign the weight to each comment based on the degrees of the clustered subgraphs, which can differentiate the meaningful comments from the noises. Finally, we gain the weight of each word by combining Semantic Weight (SW) and Inverse Document Frequency (IDF). In this way, the video tags are extracted automatically in an unsupervised way. Extensive experiments have shown that SW-IDF (dialogue-based algorithm) achieves 0.4210 F1-score and 0.4932 MAP (Mean Average Precision) in high-density comments, 0.4267 F1-score and 0.3623 MAP in low-density comments; while SW-IDF (topic center-based algorithm) achieves 0.4444 F1-score and 0.5122 MAP in high-density comments, 0.4207 F1-score and 0.3522 MAP in low-density comments. It has a better performance than the state-of-the-art unsupervised algorithms in both F1-score and MAP.

Time-sync comments reveal a new way of extracting the online video tags. However, such time-sync comments have lots of noises due to users' diverse comments, introducing great challenges for accurate and fast video tag extractions. In this paper, we propose an unsupervised video tag extraction algorithm named Semantic Weight-Inverse Document Frequency (SW-IDF). SW-IDF first generates corresponding semantic association graph (SAG) using semantic similarities and timestamps of the time-sync comments. Then it clusters the comments into sub-graphs of different topics and assigns weight to each comment based on SAG. This can clearly differentiate the meaningful comments with the noises. In this way, the noises can be identified, and effectively eliminated. Extensive experiments have shown that SW-IDF can achieve 0.3045 precision and 0.6530 recall in high-density comments; 0.3800 precision and 0.4460 recall in low-density comments. It is the best performance among the existing unsupervised algorithms.