Artificial Intelligence (AI) has rapidly transformed the medical field, necessitating significant changes in medical education to prepare healthcare professionals for future work requirements. However, the integration of AI into medical curricula has been slow and lacks standardization. In this paper, we present our work in developing a year-long postgraduate-level AI in Medicine program offered by a medical school at a public university in Singapore. Our curriculum design follows Kern's six-step approach to medical curriculum development, organized into a four-session framework. These sessions involved collaboration with hospital and university administrators, educators, industry experts, and healthcare professionals. The program is structured around three core courses: Foundational Healthcare AI, Clinical Applications of Healthcare AI, and Governance and Ethics for Healthcare AI. Each course comprises multiple modules with associated projects, emphasizing hands-on learning. The program adopts a problem-based learning approach, supported by a blended learning environment to accommodate the schedules of working healthcare professionals. Evaluations by industry experts highlight the program's potential to address critical gaps in the healthcare sector. This study contributes to the integration of AI into medical training by providing a standardized approach that can be adapted globally.

Vital signs, such as heart rate and blood pressure, are critical indicators of patient health and are widely used in clinical monitoring and decision-making. While deep learning models have shown promise in forecasting these signals, their deployment in healthcare remains limited in part because clinicians must be able to trust and interpret model outputs. Without reliable uncertainty quantification - particularly calibrated prediction intervals (PIs) - it is unclear whether a forecasted abnormality constitutes a meaningful warning or merely reflects model noise, hindering clinical decision-making. To address this, we present two methods for deriving PIs from the Reconstruction Uncertainty Estimate (RUE), an uncertainty measure well-suited to vital-sign forecasting due to its sensitivity to data shifts and support for label-free calibration. Our parametric approach assumes that prediction errors and uncertainty estimates follow a Gaussian copula distribution, enabling closed-form PI computation. Our non-parametric approach, based on k-nearest neighbours (KNN), empirically estimates the conditional error distribution using similar validation instances. We evaluate these methods on two large public datasets with minute- and hour-level sampling, representing high- and low-frequency health signals. Experiments demonstrate that the Gaussian copula method consistently outperforms conformal prediction baselines on low-frequency data, while the KNN approach performs best on high-frequency data. These results underscore the clinical promise of RUE-derived PIs for delivering interpretable, uncertainty-aware vital sign forecasts.

In recent years, deep learning has gained traction in medical research, particularly in addressing challenges related to predicting outcomes from irregularly sampled time-series data. This irregularity, stemming from inconsistent follow-up appointments and vital sign recordings, poses significant hurdles for traditional machine learning techniques reliant on regularly sampled data. To overcome this, researchers have developed two main categories of methods: interpolation-based and non-interpolation-based models. Our study proposes STraTS-mTAND, a novel approach that integrates techniques from both categories to predict outcomes from irregularly sampled time-series data. By leveraging the strengths of STraTS, a non-interpolation model, and mTAND, an interpolation model, our approach aims to mitigate their respective limitations. Evaluation on datasets like the PhysioNet Challenge 2012 and MIMIC-III demonstrates superior performance compared to existing methods, showing improvements in both PR-AUC and ROC-AUC metrics. Notably, our approach exhibits robustness with less training data and performs effectively with sparser and more irregular time series—characteristics inherent in recorded medical data. Additionally, our analysis offers insights into optimizing predictive modelling in healthcare, potentially reducing costs associated with data extraction and management, shortening operational cycles for model development and deployment, and enhancing digital agility and sustainability within the healthcare sector.

Analyzing patient health through irregular time series vital sign data demands innovative methods beyond conventional imputation techniques. This study introduces a novel approach diverging from prevailing attention-based models to explicitly capture temporal patient evolution. We adopt a paradigm where patients are viewed as dynamic systems evolving over time, with their vital signs encapsulating the system’s states. Our conceptual framework draws parallels to a Markov chain, exploring the transitions between states within a unit of time. To navigate the challenge of a vast state space, we employ a neural network to model expected transitions. Our method portrays the patient’s progression within one unit of time as the system evolves from one state to another, and forecasts states into the future. We outline the training process using irregular time series data and demonstrate its efficacy through analysis on two large vital sign data sets. Comparative analysis against attention-based models emphasizes the effectiveness and efficiency of our approach. This research heralds a promising avenue for patient vital sign analysis, providing insights into temporal patient evolution without relying on imputation methods, thereby enhancing predictive accuracy and interpretability of models.