Named entity recognition (NER) is a key task in natural language processing, but existing methods often fail to effectively handle nested structures due to fuzzy entity boundaries and structural ambiguity. To address this challenge, we propose a novel nested NER method based on an IoU-aware denoising diffusion model, which formulates the nested NER task as a generative denoising process that progressively recovers gold entity spans from noisy span proposals. We generate noisy samples during training by gradually adding Gaussian noise to the ground-truth entity boundaries. We then train a denoiser incorporating a top-k selective attention mechanism to refine entity span proposals iteratively. To strengthen the alignment between boundary localization and entity classification, we introduce an IoU-aware loss function that optimizes the overlap between predicted and ground-truth spans. This design more accurately guides boundary regression and effectively reduces misalignment caused by conventional regression losses. Our model leverages sentence features and timesteps as conditional inputs to capture contextual information throughout the denoising process. During inference, the model generates final entity predictions by starting from random noise spans and iteratively refining them through a multi-step reverse diffusion process. We conduct extensive experiments on four nested NER datasets, ACE2004, ACE2005, GENIA, and KBP2017, as well as two flat NER datasets, CoNLL2003 and OntoNotes. Experimental results show that the proposed method consistently outperforms existing advanced models across all benchmarks, demonstrating its effectiveness.

With the increasing complexity of Integrated Circuit design and the globalization of the supply chain, the threat posed by Hardware Trojans is becoming increasingly significant. Currently, HT detection methods based on graph neural networks demonstrate the most promising performance. However, existing GNN-based methods fail to capture global representations and edge distinctiveness, and their corresponding sampling methods are not sufficiently efficient, resulting in a low F1 score. We propose GREAT, a detection framework that accurately locates Trojans in gate-level netlists. GREAT leverages feature fusion technology to mitigate the deficiency in global representation inherent in GNN. We introduce Wire Encoding, which assigns a unique identifier to each edge, enhancing sensitivity to shared wires. Additionally, GREAT incorporates a novel graph sampling technique to reduce resource consumption and improve training efficiency. The experimental results demonstrate that the GREAT has achieved a recall of 94.58% and an F1 score of 96.18%, surpassing all existing HT detection methods on gate-level netlists.

BACKGROUND: Cryo-electron microscopy (Cryo-EM) plays an increasingly important role in the determination of the three-dimensional (3D) structure of macromolecules. In order to achieve 3D reconstruction results close to atomic resolution, 2D single-particle image classification is not only conducive to single-particle selection, but also a key step that affects 3D reconstruction. The main task is to cluster and align 2D single-grain images into non-heterogeneous groups to obtain sharper single-grain images by averaging calculations. The main difficulties are that the cryo-EM single-particle image has a low signal-to-noise ratio (SNR), cannot manually label the data, and the projection direction is random and the distribution is unknown. Therefore, in the low SNR scenario, how to obtain the characteristic information of the effective particles, improve the clustering accuracy, and thus improve the reconstruction accuracy, is a key problem in the 2D image analysis of single particles of cryo-EM. RESULTS: Aiming at the above problems, we propose a learnable deep clustering method and a fast alignment weighted averaging method based on frequency domain space to effectively improve the class averaging results and improve the reconstruction accuracy. In particular, it is very prominent in the feature extraction and dimensionality reduction module. Compared with the classification method based on Bayesian and great likelihood, a large amount of single particle data is required to estimate the relative angle orientation of macromolecular single particles in the 3D structure, and we propose that the clustering method shows good results. CONCLUSIONS: SimcryoCluster can use the contrastive learning method to perform well in the unlabeled high-noise cryo-EM single particle image classification task, making it an important tool for cryo-EM protein structure determination.