Self-supervised visual foundation models produce powerful embeddings that achieve remarkable performance on a wide range of downstream tasks. However, unlike vision-language models such as CLIP [67], self-supervised visual features are not readily aligned with language, hindering their adoption in open-vocabulary tasks. Our method, named dino.txt, unlocks this new ability for DINOv2 [63], a widely used self-supervised visual encoder. We build upon the LiT training strategy [97], which trains a text encoder to align with a frozen vision model but leads to unsatisfactory results on dense tasks. We propose several key ingredients to improve performance on both global and dense tasks, such as concatenating the [CLS] token with the patch average to train the alignment and curating data using both text and image modalities. With these, we successfully train a CLIP-like model with only a fraction of the computational cost compared to CLIP while achieving state-of-the-art results in zero-shot classification and open-vocabulary semantic segmentation.

Vector-quantized autoencoders have recently gained interest in image compression, generation and self-supervised learning. However, as a neural compression method, they lack the possibility to allocate a variable number of bits to each image location, e.g. according to the semantic content or local saliency. In this paper, we address this limitation in a simple yet effective way. We adopt a product quantizer (PQ) that produces a set of discrete codes for each image patch rather than a single index. This PQ-autoencoder is trained end-to-end with a structured dropout that selectively masks a variable number of codes at each location. These mechanisms force the decoder to reconstruct the original image based on partial information and allow us to control the local rate. The resulting model can compress images on a wide range of operating points of the rate-distortion curve and can be paired with any external method for saliency estimation to control the compression rate at a local level. We demonstrate the effectiveness of our approach on the popular Kodak and ImageNet datasets by measuring both distortion and perceptual quality metrics.

MOTIVATION: Proteins are ubiquitous molecules whose function in biological processes is determined by their 3D structure. Experimental identification of a protein's structure can be time-consuming, prohibitively expensive and not always possible. Alternatively, protein folding can be modeled using computational methods, which however are not guaranteed to always produce optimal results. GraphQA is a graph-based method to estimate the quality of protein models, that possesses favorable properties such as representation learning, explicit modeling of both sequential and 3D structure, geometric invariance and computational efficiency. RESULTS: GraphQA performs similarly to state-of-the-art methods despite using a relatively low number of input features. In addition, the graph network structure provides an improvement over the architecture used in ProQ4 operating on the same input features. Finally, the individual contributions of GraphQA components are carefully evaluated. AVAILABILITY AND IMPLEMENTATION: PyTorch implementation, datasets, experiments and link to an evaluation server are available through this GitHub repository: github.com/baldassarreFe/graphqa. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.