One can fix the randomness used by a randomized algorithm, but there is no analogous notion of fixing the quantumness used by a quantum algorithm. Underscoring this fundamental difference, we show that, in the black-box setting, the behavior of quantum polynomial-time ($\mathsf{BQP}$) can be remarkably decoupled from that of classical complexity classes like $\mathsf{NP}$. Specifically: -There exists an oracle relative to which $\mathsf{NP^{BQP}}\not\subset\mathsf{BQP^{PH}}$, resolving a 2005 problem of Fortnow. As a corollary, there exists an oracle relative to which $\mathsf{P}=\mathsf{NP}$ but $\mathsf{BQP}\neq\mathsf{QCMA}$. -Conversely, there exists an oracle relative to which $\mathsf{BQP^{NP}}\not\subset\mathsf{PH^{BQP}}$. -Relative to a random oracle, $\mathsf{PP}=\mathsf{PostBQP}$ is not contained in the "$\mathsf{QMA}$ hierarchy" $\mathsf{QMA}^{\mathsf{QMA}^{\mathsf{QMA}^{\cdots}}}$. -Relative to a random oracle, $\mathsfΣ_{k+1}^\mathsf{P}\not\subset\mathsf{BQP}^{\mathsfΣ_{k}^\mathsf{P}}$ for every $k$. -There exists an oracle relative to which $\mathsf{BQP}=\mathsf{P^{\# P}}$ and yet $\mathsf{PH}$ is infinite. -There exists an oracle relative to which $\mathsf{P}=\mathsf{NP}\neq\mathsf{BQP}=\mathsf{P^{\# P}}$. To achieve these results, we build on the 2018 achievement by Raz and Tal of an oracle relative to which $\mathsf{BQP}\not \subset \mathsf{PH}$, and associated results about the Forrelation problem. We also introduce new tools that might be of independent interest. These include a "quantum-aware" version of the random restriction method, a concentration theorem for the block sensitivity of $\mathsf{AC^0}$ circuits, and a (provable) analogue of the Aaronson-Ambainis Conjecture for sparse oracles.