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Marta Adinolfi

dblp:216/4447 · DBLP profile ↗
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1ranked-venue papers
0as first author
0since 2021 · last 2018
0000-0003-3910-0271ORCID · reported

Domains — the database's venue-derived domains; a paper can count in several

Applied, interdisciplinary, general and emerging computing · 1

Expertise — from the expertise taxonomy: the topics of the expert's papers under the CCF categories. A weight counts papers with recency: 1 for a paper about the topic, 0.3 when the topic is its context, halved every five years.

Interdisciplinary, comprehensive, and emerging computing
1 paper
Bioinformatics and computational biology · 100%

Topics — the 2 heaviest of 2, each with the papers that count most for it

TopicWeightPapersLastEvidence papers
Bioinformatics and computational biology › RNA biology › RNA analysis › RNA bioinformatics
RNA structure
0.312018
BEAM web server: a tool for structural RNA motif discovery · Bioinform. 2018
Bioinformatics and computational biology
structural bioinformatics
0.312018
BEAM web server: a tool for structural RNA motif discovery · Bioinform. 2018

Methods — techniques the papers use, named apart from their topics

substitution matrix · 0.3secondary structure prediction · 0.3BEAR encoding · 0.3
YearPublicationVenuePosition
2018 BEAM web server: a tool for structural RNA motif discovery
abstract
Motivation: RNA structural motif finding is a relevant problem that becomes computationally hard when working on high-throughput data (e.g. eCLIP, PAR-CLIP), often represented by thousands of RNA molecules. Currently, the BEAM server is the only web tool capable to handle tens of thousands of RNA in input with a motif discovery procedure that is only limited by the current secondary structure prediction accuracies. Results: The recently developed method BEAM (BEAr Motifs finder) can analyze tens of thousands of RNA molecules and identify RNA secondary structure motifs associated to a measure of their statistical significance. BEAM is extremely fast thanks to the BEAR encoding that transforms each RNA secondary structure in a string of characters. BEAM also exploits the evolutionary knowledge contained in a substitution matrix of secondary structure elements, extracted from the RFAM database of families of homologous RNAs. The BEAM web server has been designed to streamline data pre-processing by automatically handling folding and encoding of RNA sequences, giving users a choice for the preferred folding program. The server provides an intuitive and informative results page with the list of secondary structure motifs identified, the logo of each motif, its significance, graphic representation and information about its position in the RNA molecules sharing it. Availability and implementation: The web server is freely available at http://beam.uniroma2.it/ and it is implemented in NodeJS and Python with all major browsers supported. Contact: [email protected]. Supplementary information: Supplementary data are available at Bioinformatics online.
Marco Pietrosanto, Marta Adinolfi, Riccardo Casula, Gabriele Ausiello, Fabrizio Ferrè, Manuela Helmer-Citterich
Bioinform.2