Myocardial infarction (MI) is a leading cause of death worldwide. Late gadolinium enhancement (LGE) and T2-weighted cardiac magnetic resonance (CMR) imaging can respectively identify scarring and edema areas, both of which are essential for MI risk stratification and prognosis assessment. Although combining complementary information from multi-sequence CMR is useful, acquiring these sequences can be time-consuming and prohibitive, e.g., due to the administration of contrast agents. Cine CMR is a rapid and contrast-free imaging technique that can visualize both motion and structural abnormalities of the myocardium induced by acute MI. Therefore, we present a new end-to-end deep neural network, referred to as CineMyoPS, to segment myocardial pathologies, i.e., scars and edema, solely from cine CMR images. Specifically, CineMyoPS extracts both motion and anatomy features associated with MI. Given the interdependence between these features, we design a consistency loss (resembling the co-training strategy) to facilitate their joint learning. Furthermore, we propose a time-series aggregation strategy to integrate MI-related features across the cardiac cycle, thereby enhancing segmentation accuracy for myocardial pathologies. Experimental results on a multi-center dataset demonstrate that CineMyoPS achieves promising performance in myocardial pathology segmentation, motion estimation, and anatomy segmentation.

Optical deep learning (DL) accelerators have attracted significant interests due to their latency and power advantages. In this article, we focus on incoherent optical designs. A significant challenge is that there is no known solution to perform single-wavelength accumulation (a key operation required for DL workloads) using incoherent optical signals efficiently. Therefore, we devise a hybrid approach, where accumulation is done in the electrical domain, and multiplication is performed in the optical domain. The key technology enabler of our design is the transistor laser, which performs electrical-to-optical and optical-to-electrical conversions efficiently. Through detailed design and evaluation of our design, along with a comprehensive benchmarking study against state-of-the-art RRAM-based designs, we derive the following key results: (1) For a four-layer multilayer perceptron network, our design achieves 115× and 17.11× improvements in latency and energy, respectively, compared to the RRAM-based design. We can take full advantage of the speed and energy benefits of the optical technology because the inference task can be entirely mapped onto our design. (2) For a complex workload (Resnet50), weight reprogramming is needed, and intermediate results need to be stored/re-fetched to/from memories. In this case, for the same area, our design still outperforms the RRAM-based design by 15.92× in inference latency, and 8.99× in energy.

Myocardial pathology segmentation (MyoPS) is critical for the risk stratification and treatment planning of myocardial infarction (MI). Multi-sequence cardiac magnetic resonance (MS-CMR) images can provide valuable information. For instance, balanced steady-state free precession cine sequences present clear anatomical boundaries, while late gadolinium enhancement and T2-weighted CMR sequences visualize myocardial scar and edema of MI, respectively. Existing methods usually fuse anatomical and pathological information from different CMR sequences for MyoPS, but assume that these images have been spatially aligned. However, MS-CMR images are usually unaligned due to the respiratory motions in clinical practices, which poses additional challenges for MyoPS. This work presents an automatic MyoPS framework for unaligned MS-CMR images. Specifically, we design a combined computing model for simultaneous image registration and information fusion, which aggregates multi-sequence features into a common space to extract anatomical structures (i.e., myocardium). Consequently, we can highlight the informative regions in the common space via the extracted myocardium to improve MyoPS performance, considering the spatial relationship between myocardial pathologies and myocardium. Experiments on a private MS-CMR dataset and a public dataset from the MYOPS2020 challenge show that our framework could achieve promising performance for fully automatic MyoPS.

We present a hybrid optical-electrical analog deep learning (DL) accelerator, the first work to use incoherent optical signals for DL workloads. Incoherent optical designs are more attractive than coherent ones as the former can be more easily realized in practice. However, a significant challenge in analog DL accelerators, where multiply-accumulate operations are dominant, is that there is no known solution to perform accumulation using incoherent optical signals. We overcome this challenge by devising a hybrid approach: accumulation is done in the electrical domain, while multiplication is performed in the optical domain. The key technology enabler of our design is the transistor laser, which performs electrical-to-optical and optical-to-electrical conversions efficiently to tightly integrate electrical and optical devices into compact circuits. As such, our design fully realizes the ultra high-speed and high-energy-efficiency advantages of analog and optical computing. Our evaluation results using the MNIST benchmark show that our design achieves 2214× and 65× improvements in latency and energy, respectively, compared to a state-of-the-art memristor-based analog design.

We present the first all-optical network, Baldur, to enable power-efficient and high-speed communications in future exascale computing systems. The essence of Baldur is its ability to perform packet routing on-the-fly in the optical domain using an emerging technology called the transistor laser (TL), which presents interesting opportunities and challenges at the system level. Optical packet switching readily eliminates many inefficiencies associated with the crossings between optical and electrical domains. However, TL gates consume high power at the current technology node, which makes TL-based buffering and optical clock recovery impractical. Consequently, we must adopt novel (bufferless and clock-less) architecture and design approaches that are substantially different from those used in current networks. At the architecture level, we support a bufferless design by turning to techniques that have fallen out of favor for current networks. Baldur uses a low-radix, multi-stage network with a simple routing algorithm that drops packets to handle congestion, and we further incorporate path multiplicity and randomness to minimize packet drops. This design also minimizes the number of TL gates needed in each switch. At the logic design level, a non-conventional, length-based data encoding scheme is used to eliminate the need for clock recovery. We thoroughly validate and evaluate Baldur using a circuit simulator and a network simulator. Our results show that Baldur achieves up to 3,000X lower average latency while consuming 3.2X-26.4X less power than various state-of-the art networks under a wide variety of traffic patterns and real workloads, for the scale of 1,024 server nodes. Baldur is also highly scalable, since its power per node stays relatively constant as we increase the network size to over 1 million server nodes, which corresponds to 14.6X-31.0X power improvements compared to state-of-the-art networks at this scale.