Cell detection is a fundamental task in computational pathology that can be used for extracting high-level medical information from whole-slide images. For accurate cell detection, pathologists often zoom out to understand the tissue-level structures and zoom in to classify cells based on their morphology and the surrounding context. However, there is a lack of efforts to reflect such behaviors by pathologists in the cell detection models, mainly due to the lack of datasets containing both cell and tissue annotations with overlapping regions. To overcome this limitation, we propose and publicly release OCELOT, a dataset purposely dedicated to the study of cell-tissue relationships for cell detection in histopathology. OCELOT provides overlapping cell and tissue annotations on images acquired from multiple organs. Within this setting, we also propose multi-task learning approaches that benefit from learning both cell and tissue tasks simultaneously. When compared against a model trained only for the cell detection task, our proposed approaches improve cell detection performance on 3 datasets: proposed OCELOT, public TIGER, and internal CARP datasets. On the OCELOT test set in particular, we show up to 6.79 improvement in F1-score. We believe the contributions of this paper, including the release of the OCELOT dataset at https://lunit-io.github.io/research/publications/OCELOT are a crucial starting point toward the important research direction of incorporating cell-tissue relationships in computation pathology.

Homomorphic encryption (HE) enables the secure offloading of computations to the cloud by providing computation on encrypted data (ciphertexts). HE is based on noisy encryption schemes in which noise accumulates as more computations are applied to the data. The limited number of operations applicable to the data prevents practical applications from exploiting HE. Bootstrapping enables an unlimited number of operations or fully HE (FHE) by refreshing the ciphertext. Unfortunately, bootstrapping requires a significant amount of additional computation and memory bandwidth as well. Prior works have proposed hardware accelerators for computation primitives of FHE. However, to the best of our knowledge, this is the first to propose a hardware FHE accelerator that supports bootstrapping as a first-class citizen.

Mobile and edge devices become common platforms for inferring convolutional neural networks (CNNs) due to superior privacy and service quality. To reduce the computational costs of convolution (CONV) , recent CNN models adopt depth-wise CONV (DW-CONV) and Squeeze-and-Excitation (SE) . However, existing area-efficient CNN accelerators are sub-optimal for these latest CNN models because they were mainly optimized for compute-intensive standard CONV layers with abundant data reuse that can be pipelined with activation and normalization operations. In contrast, DW-CONV and SE are memory-intensive with limited data reuse. The latter also strongly depends on the nearby CONV layers, making an effective pipelining a daunting task. Therefore, DW-CONV and SE only occupy 10% of entire operations but become memory bandwidth bound, spending more than 60% of the processing time in systolic-array-based accelerators. We propose a CNN acceleration architecture called MVP, which efficiently processes both compute- and memory-intensive operations with a small area overhead on top of the baseline systolic-array-based architecture. We suggest a specialized vector unit tailored for processing DW-CONV, including multipliers, adder trees, and multi-banked buffers to meet the high memory bandwidth requirement. We augment the unified buffer with tiny processing elements to smoothly pipeline SE with the subsequent CONV, enabling concurrent processing of DW-CONV with standard CONV, thereby achieving the maximum utilization of arithmetic units. Our evaluation shows that MVP improves performance by 2.6 \( \times \) and reduces energy by 47% on average for EfficientNet-B0/B4/B7, MnasNet, and MobileNet-V1/V2 with only a 9% area overhead compared to the baseline.

Homomorphic Encryption (HE) [11] draws significant attention as a privacy-preserving way for cloud computing because it allows computation on encrypted messages called ciphertexts. Among numerous FHE schemes [2]–[4], [8], [9], HE for Arithmetic of Approximate Numbers (HEAAN [3]), which is also known as CKKS (Cheon-Kim-Kim-Song), is rapidly gaining popularity [10] as it supports computation on real numbers. A critical shortcoming of HE is the high computational complexity of ciphertext arithmetic, especially, HE multiplication (HE Mul). For example, the execution time for computation on encrypted data (ciphertext) increases from 100s to 10,000s of times compared to that on native, unen-crypted messages. However, a large body of HE acceleration studies, including ones exploiting GPUs and FPGAs, lack a rigorous analysis of computational complexity and data access patterns of HE Mul with large parameter sets on CPUs, the most popular computing platform.

OBJECTIVE: Pressure injuries are common and serious complications for hospitalized patients. The pressure injury rate is an important patient safety metric and an indicator of the quality of nursing care. Timely and accurate prediction of pressure injury risk can significantly facilitate early prevention and treatment and avoid adverse outcomes. While many pressure injury risk assessment tools exist, most were developed before there was access to large clinical datasets and advanced statistical methods, limiting their accuracy. In this paper, we describe the development of machine learning-based predictive models, using phenotypes derived from nurse-entered direct patient assessment data. METHODS: We utilized rich electronic health record data, including full assessment records entered by nurses, from 5 different hospitals affiliated with a large integrated healthcare organization to develop machine learning-based prediction models for pressure injury. Five-fold cross-validation was conducted to evaluate model performance. RESULTS: Two pressure injury phenotypes were defined for model development: nonhospital acquired pressure injury (N = 4398) and hospital acquired pressure injury (N = 1767), representing 2 distinct clinical scenarios. A total of 28 clinical features were extracted and multiple machine learning predictive models were developed for both pressure injury phenotypes. The random forest model performed best and achieved an AUC of 0.92 and 0.94 in 2 test sets, respectively. The Glasgow coma scale, a nurse-entered level of consciousness measurement, was the most important feature for both groups. CONCLUSIONS: This model accurately predicts pressure injury development and, if validated externally, may be helpful in widespread pressure injury prevention.

Recurrent Neural Networks (RNNs) spend most of their execution time performing matrix-vector multiplication (MV-mul). Because the matrices in RNNs have poor reusability and the ever-increasing size of the matrices becomes too large to fit in the on-chip storage of mobile/IoT devices, the performance and energy efficiency of MV-mul is determined by those of main-memory DRAM. Therefore, computing MV-mul within DRAM draws much attention. However, previous studies lacked consideration for the matrix sparsity, the power constraints of DRAM devices, and concurrency in accessing DRAM from processors while performing MV-mul. We propose a main-memory architecture called MViD, which performs MV-mul by placing MAC units inside DRAM banks. For higher computational efficiency, we use a sparse matrix format and exploit quantization. Because of the limited power budget for DRAM devices, we implement the MAC units only on a portion of the DRAM banks. We architect MViD to slow down or pause MV-mul for concurrently processing memory requests from processors while satisfying the limited power budget. Our results show that MViD provides 7.2× higher throughput compared to the baseline system with four DRAM ranks (performing MV-mul in a chip-multiprocessor) while running inference of Deep Speech 2 with a memory-intensive workload.