Test-time adaptation (TTA) is crucial for robust medical image analysis, particularly in low-dose CT denoising where models trained on one noise level often fail to generalize to unseen noise intensities. This work proposes a novel TTA method that adapts the parameters of any pre-trained denoising model to denoise unknown test images. We demonstrate that surprisingly, fine-tuning only the convolutional layer biases achieves optimal TTA performance for this task. Building upon this, we introduce a novel pseudo-labeling strategy: re-corrupting the initially restored images to generate targets for further adaptation. This pseudo-labeling is combined with a knowledge distillation framework to efficiently update the model parameters during testing. Evaluations on low-dose CT scans demonstrate significant improvements in denoising performance, with peak signal-to-noise ratio (PSNR) gains of up to 3 dB observed.

The resurgence of deep neural networks has created an alternative pathway for low-dose computed tomography denoising by learning a nonlinear transformation function between low-dose CT (LDCT) and normal-dose CT (NDCT) image pairs. However, those paired LDCT and NDCT images are rarely available in the clinical environment, making deep neural network deployment infeasible. This study proposes a novel method for self-supervised low-dose CT denoising to alleviate the requirement of paired LDCT and NDCT images. Specifically, we have trained an invertible neural network to minimize the pixel-based mean square distance between a noisy slice and the average of its two immediate adjacent noisy slices. We have shown the aforementioned is similar to training a neural network to minimize the distance between clean NDCT and noisy LDCT image pairs. Again, during the reverse mapping of the invertible network, the output image is mapped to the original input image, similar to cycle consistency loss. Finally, the trained invertible network’s forward mapping is used for denoising LDCT images. Extensive experiments on two publicly available datasets showed that our method performs favourably against other existing unsupervised methods.

This study proposes an image domain restoration network for metal artifact reduction in clinical computed tomography images. Specifically, we have proposed a pool and excite module to identify the streaking artifacts in the hidden latent space via learning a sigmoidal mask and a novel gated convolution layer, which utilises the previously learned gating weights for the reduction of metal artifacts. Our formulation of gated convolution is unique and custom-made to deal with metal artifacts. Extensive experiments on real CT images show that our method accomplishes significant improvement over the current state-of-the-art methods without requiring additional data, e.g., projection data, metal trace, etc.

Low level image restoration is an integral component of modern artificial intelligence (AI) driven camera pipelines. Most of these frameworks are based on deep neural networks which present a massive computational overhead on resource constrained platform like a mobile phone. In this paper, we propose several lightweight low-level modules which can be used to create a computationally low cost variant of a given baseline model. Recent works for efficient neural networks design have mainly focused on classification. However, low-level image processing falls under the `image-to-image' translation genre which requires some additional computational modules not present in classification. This paper seeks to bridge this gap by designing generic efficient modules which can replace essential components used in contemporary deep learning based image restoration networks. We also present and analyse our results highlighting the drawbacks of applying depthwise separable convolutional kernel (a popular method for efficient classification network) for sub-pixel convolution based upsampling (a popular upsampling strategy for low-level vision applications). This shows that concepts from domain of classification cannot always be seamlessly integrated into `image-to-image' translation tasks. We extensively validate our findings on three popular tasks of image inpainting, denoising and super-resolution. Our results show that proposed networks consistently output visually similar reconstructions compared to full capacity baselines with significant reduction of parameters, memory footprint and execution speeds on contemporary mobile devices.

The explosive rise of the use of Computer tomography (CT) imaging in medical practice has heightened public concern over the patient's associated radiation dose. On the other hand, reducing the radiation dose leads to increased noise and artifacts, which adversely degrades the scan's interpretability. In recent times, the deep learning-based technique has emerged as a promising method for low dose CT(LDCT) denoising. However, some common bottleneck still exists, which hinders deep learning-based techniques from furnishing the best performance. In this study, we attempted to mitigate these problems with three novel accretions. First, we propose a novel convolutional module as the first attempt to utilize neighborhood similarity of CT images for denoising tasks. Our proposed module assisted in boosting the denoising by a significant margin. Next, we moved towards the problem of non-stationarity of CT noise and introduced a new noise aware mean square error loss for LDCT denoising. The loss mentioned above also assisted to alleviate the laborious effort required while training CT denoising network using image patches. Lastly, we propose a novel discriminator function for CT denoising tasks. The conventional vanilla discriminator tends to overlook the fine structural details and focus on the global agreement. Our proposed discriminator leverage self-attention and pixel-wise GANs for restoring the diagnostic quality of LDCT images. Our method validated on a publicly available dataset of the 2016 NIH-AAPM-Mayo Clinic Low Dose CT Grand Challenge performed remarkably better than the existing state of the art method. The corresponding source code is available at: https://github.com/reach2sbera/ldct_nonlocal.