We study a new variant of the vehicle routing problem, which arises in hospital-wide scheduling of physical therapists. Multiple service locations exist for patients, and resource synchronization for the location capacities is required as only a limited number of patients can be treated at one location at a time. Additionally, operations synchronization between treatments is required as precedence relations exist. We develop an innovative exact branch-price-and-cut algorithm including two approaches targeting the synchronization constraints (1) based on branching on time windows and (2) based on adding combinatorial Benders cuts. We optimally solve realistic hospital instances with up to 120 treatments and find that branching on time windows performs better than adding cutting planes. Summary of Contribution: We present an exact branch-price-and-cut (BPC) algorithm for the therapist scheduling and routing problem (ThSRP), a daily planning problem arising at almost every hospital. The difficulty of this problem stems from its inherent structure that features routing and scheduling while considering multiple possible service locations with time-dependent location capacities. We model the ThSRP as a vehicle routing problem with time windows and flexible delivery locations and synchronization constraints, which are properties relevant to other vehicle routing problem variants as well. In our computational study, we show that the proposed exact BPC algorithm is capable of solving realistic hospital instances and can, thus, be used by hospital planners to derive better schedules with less manual work. Moreover, we show that time window branching can be a valid alternative to cutting planes when addressing synchronization constraints in a BPC algorithm.