Ruixuan Liu

dblp:243/0195 · DBLP profile ↗
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26ranked-venue papers
12as first author
22since 2021 · last 2026
—ORCID · conflict

Domains — the database's venue-derived domains; a paper can count in several

Artificial intelligence and machine learning · 11 · 5 first-author · 10 since 2021Security and privacy · 5 · 4 first-author · 4 since 2021Databases, data management, data science and information retrieval · 5 · 3 first-author · 3 since 2021Graphics, computer vision, multimedia, augmented reality and games · 5 · 1 first-author · 5 since 2021Applied, interdisciplinary, general and emerging computing · 5 · 1 first-author · 4 since 2021Systems, architecture and hardware · 2 · 1 first-author · 2 since 2021Computer networks · 2 · 1 first-author · 1 since 2021
YearPublicationVenuePosition
2026 ExpShield: Safeguarding Web Text from Unauthorized Crawling and LLM Exploitation
Ruixuan Liu, Tianhao Wang 0001, Hongsheng Hu, Shuo Wang 0012, Li Xiong 0001
NDSS1
2026 Beyond Indistinguishability: Measuring Extraction Risk in LLM APIs
Ruixuan Liu, David Evans 0001, Li Xiong 0001
SP1
2026 Patient-specific multimodal learning with multi-view contrastive alignment for chest X-ray report generation
abstract
MOTIVATION: Radiology reports play a pivotal role in guiding treatment planning and enabling effective doctor-patient communication. However, their manual composition imposes a substantial workload on radiologists. Although automatic radiology report generation has emerged as a promising alternative, existing approaches predominantly rely on single-view chest X-rays and fail to adequately leverage patient-specific context, thereby limiting diagnostic accuracy. RESULTS: To address this challenge, we propose EVOKE, a novel chest X-ray report generation framework that incorporates multi-view contrastive learning and patient-specific knowledge. Specifically, we introduce a multi-view contrastive learning method that captures semantic correspondences both among multi-view radiographs within a study and between these radiographs and their associated report, thereby improving visual representation learning. We further present a knowledge-guided report generation module that integrates available patient-specific knowledge (i.e., indication, which includes symptom descriptions) to facilitate the generation of accurate and coherent radiology reports. To support research in multi-view report generation, we construct Multiview CXR and Two-view CXR datasets using publicly available sources. Our proposed EVOKE surpasses recent state-of-the-art methods across multiple datasets, achieving a 2.9% F1 RadGraph improvement on MIMIC-CXR, a 5.0% BLEU-1 improvement on MIMIC-ABN, a 1.5% BLEU-4 improvement on Multi-view CXR, and an 8.2% F1,mic-14 CheXbert improvement on Two-view CXR. AVAILABILITY: Code is publicly available at https://github.com/mk-runner/EVOKE, with an archived release available on Zenodo (doi:10.5281/zenodo.21000219).
Qiguang Miao, Kang Liu 0025, Zhuoqi Ma, Yunan Li 0001, Xiaolu Kang, Ruixuan Liu, Kun Xie 0011
Bioinform.6
2025 MultiSFL: Towards Accurate Split Federated Learning via Multi-Model Aggregation and Knowledge Replay
abstract
Although Split Federated Learning (SFL) effectively enables knowledge sharing among resource-constrained clients, it suffers from low training performance due to the neglect of data heterogeneity and catastrophic forgetting problems. To address these issues, we propose a novel SFL approach named MultiSFL, which adopts i) an effective multi-model aggregation mechanism to alleviate gradient divergence caused by heterogeneous data and ii) a novel knowledge replay strategy to deal with the catastrophic forgetting problem. MultiSFL adopts two servers (i.e., the fed server and main server) to maintain multiple branch models for local training and an aggregated master model for knowledge sharing among branch models. To mitigate catastrophic forgetting, the main server of MultiSFL selects multiple assistant devices for knowledge replay according to the training data distribution of each full branch model. Experimental results obtained from various non-IID and IID scenarios demonstrate that MultiSFL significantly outperforms conventional SFL methods by up to a 23.25% test accuracy improvement.
Zeke Xia, Ming Hu 0003, Dengke Yan, Ruixuan Liu, Anran Li 0001, Xiaofei Xie, Mingsong Chen 0001
AAAI4
2025 Generating Physically Stable and Buildable Brick Structures from Text
Ava Pun, Kangle Deng, Ruixuan Liu, Deva Ramanan, Changliu Liu, Jun-Yan Zhu
ICCV3
2025 Towards Realistic Lens Flare Removal: A Data-Centric Approach with Enhanced Synthetic Diversity
Ruixuan Liu
ICIC (14)1
2025 Towards hyperparameter-free optimization with differential privacy
abstract
Differential privacy (DP) is a privacy-preserving paradigm that protects the training data when training deep learning models. Critically, the performance of models is determined by the training hyperparameters, especially those of the learning rate schedule, thus requiring fine-grained hyperparameter tuning on the data. In practice, it is common to tune the learning rate hyperparameters through the grid search that (1) is computationally expensive as multiple runs are needed, and (2) increases the risk of data leakage as the selection of hyperparameters is data-dependent. In this work, we adapt the automatic learning rate schedule to DP optimization for any models and optimizers, so as to significantly mitigate or even eliminate the cost of hyperparameter tuning when applied together with automatic per-sample gradient clipping. Our hyperparameter-free DP optimization is almost as computationally efficient as the standard non-DP optimization, and achieves state-of-the-art DP performance on various language and vision tasks.
Ruixuan Liu, Zhiqi Bu
ICLR1
2025 Time-Optimal Trajectory Generation with Multi-level Continuous Kinodynamics Constraints
abstract
Time-optimal trajectory generation (TOTG) is critical in robotics applications to minimize travel time and increase robot task efficiency. To ensure the trajectory is feasible and executable by the robot, it is important to constrain the trajectory kinodynamics subject to the robot actuator limits. A typical actuator has multiple limits, 1) peak limit, and 2) multi-level continuous limits with different operation time windows. The peak limit bounds the instantaneous kinodynamics (IKD), whereas the continuous limits bound the system continuous kinodynamics (CKD). Existing works only constrain IKD, usually by the actuator peak limit, to achieve time optimality. However, a joint capable of operating at its peak limit momentarily will overheat and damage robot life if the motion continues. Alternatively, users can constrain the IKD with a reduced peak limit to avoid violating continuous limits. However, the reduced peak limit would inevitably sacrifice task efficiency. To address the challenge, this paper studies TOTG with both IKD and CKD, and proposes TOTG-C. It formulates the TOTG as a nonlinear programming (NLP). In particular, it proposes a novel formulation to encode the multi-level CKD constraints efficiently. To the best of our knowledge, TOTG-C is the first work that explicitly considers multi-level CKD constraints. We demonstrate the effectiveness and robustness of the proposed TOTG-C both in simulation and real robot experiments.
Ruixuan Liu, Changliu Liu, Jessica Leu
IROS1
2025 Eye-In-Finger: Smart Fingers for Delicate Assembly and Disassembly of LEGO
abstract
Manipulation and insertion of small and tight-toleranced objects in robotic assembly remain a critical challenge for vision-based robotics systems due to the required precision and cluttered environment. Conventional global or wrist-mounted cameras often suffer from occlusions when either assembling or disassembling from an existing structure. To address the challenge, this paper introduces "Eye-In-Finger", a novel tool design approach that enhances robotic manipulation by embedding low-cost, high-resolution perception directly at the tool tip. We validate our approach using LEGO assembly and disassembly tasks, which require the robot to manipulate in a cluttered environment and achieve sub-millimeter accuracy and robust error correction due to the tight tolerances. Experimental results demonstrate that our proposed system enables real-time, fine corrections to alignment error, increasing the tolerance of calibration error from 0.4mm to up to 2.0mm for the LEGO manipulation robot.
Zhenran Tang, Ruixuan Liu, Changliu Liu
IROS2
2025 Differentially Private Visual Learning with Public Subspace Augmented by Synthetic Data
abstract
Subspace-based DPSGD has emerged as a robust solution for alleviating excessive noise in high-dimensional, privacy-preserving visual learning. It achieves a favorable privacy-utility balance by projecting privatized gradients onto a low-rank subspace derived from in-distribution public data. However, relying solely on limited public data can narrow the diversity of the anchored subspace and induce over-memorization into model training, leading to suboptimal private optimization.To overcome these limitations, we propose a synthesis-augmented subspace-based DPSGD framework, SAS-DPSGD, which integrates synthetic data into the subspace construction process. We quantitatively analyze the private optimization performance using the subspace derived from the mixed public and synthetic data, revealing the benefits as well as the saturation effects of incorporating synthetic data in private visual learning. To the best of our knowledge, this is the first work to provide a unified theoretical guarantee to synthesis-augmented subspace-based DPSGD. Moreover, we design an early projection mechanism within our framework that projects the gradient onto the subspace before performing gradient clipping. This mechanism effectively reduces the gradient clipping bias and lowers the synthetic data requirement, resulting in a faster convergence rate. Extensive experiments on two real-world datasets validate that SAS-DPSGD outperforms nine baselines by up to 9.78% in accuracy and can reduce the amount of synthetic data required by 66.7%.
Haichao Sha, Yuncheng Wu, Ruixuan Liu, Yang Cao 0011, Hong Chen 0001
ACM Multimedia3
2025 TransFed: cross-domain feature alignment for semi-supervised federated transfer learning
Linghui Zeng, Ruixuan Liu, Li Xiong 0001, Joyce C. Ho
Mach. Learn.2
2025 FedGraft: Memory-Aware Heterogeneous Federated Learning via Model Grafting
abstract
Although Federated Learning (FL) is good at collaborative learning among devices without compromising their data privacy, it suffers from the problem of large-scale deployment in Mobile Edge Computing (MEC) applications. This is mainly because the varying memory sizes of edge devices inevitably result in limited sizes of their hosting models. According to the Cannikin Law, when dealing with heterogeneous devices with different memory sizes, the learning capability of existing homogeneous FL schemes is greatly restricted by the weakest device. Worse still, although existing heterogeneous FL methods enable a MEC application to involve numerous devices equipped with heterogeneous models, their knowledge aggregation processes require either extra training data or architecture similarity of models. To address the above issues, this paper presents a novel FL method named FedGraft that enables effective knowledge sharing among heterogeneous device models of different sizes without imposing unrealistic assumptions. In FedGraft, all the device models are grafted to a common rootstock based on our proposed model partitioning and grafting mechanism, facilitating knowledge sharing among heterogeneous models on top of a tree-like global model. Meanwhile, using our proposed device selection strategy, the reassembled submodels extracted from the global model can be reasonably dispatched to corresponding devices with sufficient memory, thus enhancing the overall FL performance. Comprehensive experimental results show that, compared with state-of-the-art heterogeneous FL methods, FedGraft can improve inference accuracy by up to 17% in various memory-constrained scenarios.
Ruixuan Liu, Ming Hu 0003, Zeke Xia, Xiaofei Xie, Jun Xia 0003, Yihao Huang 0001, Mingsong Chen 0001
IEEE Trans. Mob. Comput.1
2024 PreCurious: How Innocent Pre-Trained Language Models Turn into Privacy Traps
abstract
The pre-training and fine-tuning paradigm has demonstrated its effectiveness and has become the standard approach for tailoring language models to various tasks. Currently, community-based platforms offer easy access to various pre-trained models, as anyone can publish without strict validation processes. However, a released pre-trained model can be a privacy trap for fine-tuning datasets if it is carefully designed. In this work, we propose PreCurious framework to reveal the new attack surface where the attacker releases the pre-trained model and gets a black-box access to the final fine-tuned model. PreCurious aims to escalate the general privacy risk of both membership inference and data extraction on the fine-tuning dataset. The key intuition behind PreCurious is to manipulate the memorization stage of the pre-trained model and guide fine-tuning with a seemingly legitimate configuration. While empirical and theoretical evidence suggests that parameter-efficient and differentially private fine-tuning techniques can defend against privacy attacks on a fine-tuned model, PreCurious demonstrates the possibility of breaking up this invulnerability in a stealthy manner compared to fine-tuning on a benign pre-trained model. While DP provides some mitigation for membership inference attack, by further leveraging a sanitized dataset, PreCurious demonstrates potential vulnerabilities for targeted data extraction even under differentially private tuning with a strict privacy budget e.g. ε=0.05. Thus, PreCurious raises warnings for users on the potential risks of downloading pre-trained models from unknown sources, relying solely on tutorials or common-sense defenses, and releasing sanitized datasets even after perfect scrubbing.
Ruixuan Liu, Tianhao Wang 0001, Yang Cao 0011, Li Xiong 0001
CCS1
2023 PrivateRec: Differentially Private Model Training and Online Serving for Federated News Recommendation
abstract
Federated recommendation can potentially alleviate the privacy concerns in collecting sensitive and personal data for training personalized recommendation systems. However, it suffers from a low recommendation quality when a local serving is inapplicable due to the local resource limitation and the data privacy of querying clients is required in online serving. Furthermore, a theoretically private solution in both the training and serving of federated recommendation is essential but still lacking. Naively applying differential privacy (DP) to the two stages in federated recommendation would fail to achieve a satisfactory trade-off between privacy and utility due to the high-dimensional characteristics of model gradients and hidden representations. In this work, we propose a federated news recommendation method for achieving better utility in model training and online serving under a DP guarantee. We first clarify the DP definition over behavior data for each round in the pipeline of federated recommendation systems. Next, we propose a privacy-preserving online serving mechanism under this definition based on the idea of decomposing user embeddings with public basic vectors and perturbing the lower-dimensional combination coefficients. We apply a random behavior padding mechanism to reduce the required noise intensity for better utility. Besides, we design a federated recommendation model training method, which can generate effective and public basic vectors for serving while providing DP for training participants. We avoid the dimension-dependent noise for large models via label permutation and differentially private attention modules. Experiments on real-world news recommendation datasets validate that our method achieves superior utility under a DP guarantee in both training and serving of federated news recommendations.
Ruixuan Liu, Yang Cao 0011, Yanlin Wang 0001, Lingjuan Lyu, Yun Chen 0007, Hong Chen 0001
KDD1
2023 Hadamard Encoding Based Frequent Itemset Mining under Local Differential Privacy
Dan Zhao 0009, Suyun Zhao, Hong Chen 0001, Ruixuan Liu, Cuiping Li 0001
J. Comput. Sci. Technol.4
2023 LuxGeo: Efficient and Security-Enhanced Geometric Range Queries
abstract
As the location-based applications ourishing, we will witness soon the transferring of a prodigious amount of data from the local to a public cloud. The rising demand for outsourced data is moving toward a wider geographical area with arbitrary distribution (i.e., dense or sparse) and query scope (i.e., limited or vast). In terms of cloud risks, the outsourced individual data should be preserved when being queried, especially for location information. Geometric range queries are one of the most fundamental search functions. However, the existed works of secure geometric queries are far from practical usage on efciency and security simultaneously. In this paper, we propose a novel scheme, LuxGeo. Our scheme reaches a constant navigation and a linear sweep, which is tailored for secure and efcient location-lookup. Our experiments over three real-world spatial datasets have shown its practical efciency. For example, it only takes 10.01s with 728 tuples retrieved over 63, 369 ciphertext dataset for a single query. LuxGeo has better performance than the existed solutions for a GSE problem on efciency and security.
Ruoyang Guo, Yuncheng Wu, Ruixuan Liu, Hong Chen 0001, Cuiping Li 0001
IEEE Trans. Knowl. Data Eng.4
2022 Fldp: Flexible Strategy For Local Differential Privacy
abstract
Local differential privacy (LDP), a technique applying unbiased statistical estimations instead of real data, is often adopted in data collection. In particular, this technique is used in frequency oracles (FO) because it can protect each user’s privacy and prevent leakage of sensitive information. However, the definition of LDP is so conservative that it requires all inputs to be indistinguishable after perturbation. Indeed, LDP protects each value; however, it is rarely used in practical scenarios owing to its cost in terms of accuracy. In this paper, we address the challenge of providing weakened but flexible protection where each value only needs to be indistinguishable from part of the domain after perturbation. First, we present this weakened but flexible LDP (FLDP) notion which splits the domain. We then prove the association with LDP. Second, we design a Flexible Hadamard Response (FHR) approach for the common FO issue while satisfying FLDP. The proposed approach balances communication cost, computational complexity, and estimation accuracy. Finally, experimental results using practical and synthetic datasets verify the effectiveness and efficiency of our approach.
Dan Zhao 0009, Hong Chen 0001, Suyun Zhao, Ruixuan Liu, Cuiping Li 0001
ICASSP4
2022 No One Left Behind: Inclusive Federated Learning over Heterogeneous Devices
abstract
Federated learning (FL) is an important paradigm for training global models from decentralized data in a privacy-preserving way. Existing FL methods usually assume the global model can be trained on any participating client. However, in real applications, the devices of clients are usually heterogeneous, and have different computing power. Although big models like BERT have achieved huge success in AI, it is difficult to apply them to heterogeneous FL with weak clients. The straightforward solutions like removing the weak clients or using a small model to fit all clients will lead to some problems, such as under-representation of dropped clients and inferior accuracy due to data loss or limited model representation ability. In this work, we propose InclusiveFL, a client-inclusive federated learning method to handle this problem. The core idea of InclusiveFL is to assign models of different sizes to clients with different computing capabilities, bigger models for powerful clients and smaller ones for weak clients. We also propose an effective method to share the knowledge among local models with different sizes. In this way, all the clients can participate in FL training, and the final model can be big and powerful enough. Besides, we propose a momentum knowledge distillation method to better transfer knowledge in big models on powerful clients to the small models on weak clients. Extensive experiments on many real-world benchmark datasets demonstrate the effectiveness of InclusiveFL in learning accurate models from clients with heterogeneous devices under the FL framework.
Ruixuan Liu, Fangzhao Wu, Chuhan Wu, Yanlin Wang 0001, Lingjuan Lyu, Hong Chen 0001, Xing Xie 0001
KDD1
2022 A hybrid BCI system combining motor imagery and conceptual imagery in a smart home environment
abstract
In this study, we combined the advantages of two spontaneous brain-computer interface instruction paradigms, conceptual imagery and motor imagery, to develop a smart home control system with better semantics for device selection and more types of device operations. The BCI system allowed users to control three kinds of household equipment: lamps, water heaters, and electric fans. A Raspberry Pi was used to simulate the usage scenarios, where users issued instructions for home equipment selection through conceptual imagery and issued specific instructions for home equipment control through motor imagery. We used Emotiv Epoc to collect EEG data and sent the data to Raspberry Pi, and we built a deep learning-based model for data processing and classification, converting EEG signals into command signals that could control home equipment. Five subjects were recruited to test the performance of the smart home control system and completed a questionnaire to evaluate their willingness to use the system after the experiments. The average accuracy rate of the system operation was 68.9%, with the highest of 73.3%, which proved that the brain-computer interface control system combining the two instruction paradigms was feasible. Users generally showed acceptance of the ease of the system use, giving an average of 5.4 out of 6 ratings.
Ruixuan Liu, Muyang Lyu, Jiangrong Yang
TrustCom1
2022 Efficient protocols for heavy hitter identification with local differential privacy
Dan Zhao 0009, Suyun Zhao, Hong Chen 0001, Ruixuan Liu, Cuiping Li 0001, Wenjuan Liang
Frontiers Comput. Sci.4
2021 FLAME: Differentially Private Federated Learning in the Shuffle Model
abstract
Federated Learning (FL) is a promising machine learning paradigm that enables the analyzer to train a model without collecting users' raw data. To ensure users' privacy, differentially private federated learning has been intensively studied. The existing works are mainly based on the curator model or local model of differential privacy. However, both of them have pros and cons. The curator model allows greater accuracy but requires a trusted analyzer. In the local model where users randomize local data before sending them to the analyzer, a trusted analyzer is not required but the accuracy is limited. In this work, by leveraging the \textit{privacy amplification} effect in the recently proposed shuffle model of differential privacy, we achieve the best of two worlds, i.e., accuracy in the curator model and strong privacy without relying on any trusted party. We first propose an FL framework in the shuffle model and a simple protocol (SS-Simple) extended from existing work. We find that SS-Simple only provides an insufficient privacy amplification effect in FL since the dimension of the model parameter is quite large. To solve this challenge, we propose an enhanced protocol (SS-Double) to increase the privacy amplification effect by subsampling. Furthermore, for boosting the utility when the model size is greater than the user population, we propose an advanced protocol (SS-Topk) with gradient sparsification techniques. We also provide theoretical analysis and numerical evaluations of the privacy amplification of the proposed protocols. Experiments on real-world dataset validate that SS-Topk improves the testing accuracy by 60.7% than the local model based FL. We highlight an observation that SS-Topk improves the accuracy by 33.94\% than the curator model based FL without any trusted party. Compared with non-private FL, our protocol SS-Topk only lose 1.48% accuracy under (2.348, 5e-6)-DP per epoch.
Ruixuan Liu, Yang Cao 0011, Hong Chen 0001, Ruoyang Guo, Masatoshi Yoshikawa
AAAI1
2021 Efficient-FedRec: Efficient Federated Learning Framework for Privacy-Preserving News Recommendation
abstract
News recommendation is critical for personalized news access.Most existing news recommendation methods rely on centralized storage of users' historical news click behavior data, which may lead to privacy concerns and hazards.Federated Learning is a privacy-preserving framework for multiple clients to collaboratively train models without sharing their private data.However, the computation and communication cost of directly learning many existing news recommendation models in a federated way are unacceptable for user clients.In this paper, we propose an efficient federated learning framework for privacy-preserving news recommendation.Instead of training and communicating the whole model, we decompose the news recommendation model into a large news model maintained in the server and a light-weight user model shared on both server and clients, where news representations and user model are communicated between server and clients.More specifically, the clients request the user model and news representations from the server, and send their locally computed gradients to the server for aggregation.The server updates its global user model with the aggregated gradients, and further updates its news model to infer updated news representations.Since the local gradients may contain private information, we propose a secure aggregation method to aggregate gradients in a privacy-preserving way.Experiments on two real-world datasets show that our method can reduce the computation and communication cost on clients while keep promising model performance.
Jingwei Yi, Fangzhao Wu, Chuhan Wu, Ruixuan Liu, Guangzhong Sun, Xing Xie 0001
EMNLP (1)4
2020 FedSel: Federated SGD Under Local Differential Privacy with Top-k Dimension Selection
Ruixuan Liu, Yang Cao 0011, Masatoshi Yoshikawa, Hong Chen 0001
DASFAA (1)1
2020 A Pufferfish privacy mechanism for monitoring web browsing behavior under temporal correlations
Wenjuan Liang, Hong Chen 0001, Ruixuan Liu, Yuncheng Wu, Cuiping Li 0001
Comput. Secur.3
2019 Local Differential Privacy with K-anonymous for Frequency Estimation
abstract
Data release, such as statistics of data distribution, in many data analysis and machine learning tasks is needed, which poses significant risks of user's privacy. Usually, to preserve privacy of every individual, frequency estimation based on LDP (Local Differential Privacy) is used to replace the real distribution of data. Unfortunately, when an individual sends values multiple times, privacy leakage, i.e., same value problems may occur, along with other performance problems such as memory usage problem. To narrow these gaps, SAnonLDP (Sample Anonymous Local Differential Privacy) is proposed in this paper. We build the SAnonLDP framework by integrating k-anonymous into LDP, which includes four blocks: random grouping; anonymous and Walsh-Fourier transforms; random response; singular value decomposition (SVD). Among them, the second block 'Anonymous and Walsh-Fourier transforms' significantly decreases the communication cost and the memory requirements. The left blocks make up for the loss of information to achieve an acceptable frequency estimation. More important, we verify that this estimation is unbiased by the strict mathematical reasoning. Finally, the numerical experiments demonstrate that SAnonLAP achieves better KL-divergence and estimation error compared to another known privacy model: RAPPOR.
Dan Zhao 0009, Hong Chen 0001, Suyun Zhao, Cuiping Li 0001, Ruixuan Liu
IEEE BigData6
2019 MixGeo: efficient secure range queries on encrypted dense spatial data in the cloud
abstract
As the location-based applications are flourishing, we will witness soon a prodigious amount of spatial data will be stored in the public cloud with the geometric range query as one of the most fundamental search functions. The rising demand of outsourced data is moving larger-scale datasets and wider-scope query size. To protect the confidentiality of the geographic information of individuals, the outsourced data stored at the cloud server should be preserved especially when they are queried. While the problem of secure range query on outsourced encrypted data has been extensively studied, the current schemes are far from the practice in terms of efficiency and scalability. In this paper, we propose a novel solution based on Geohash and predicate symmetric searchable encryption for secure range queries named as MixGeo. We present a multi-level indexes structure tailored for efficient and large-scale spatial data lookup in the cloud server while preserving data privacy.
Ruoyang Guo, Yuncheng Wu, Ruixuan Liu, Hong Chen 0001, Cuiping Li 0001
IWQoS4