SUMMARY: We previously developed the LDM for testing hypotheses about the microbiome that performs the test at both the community level and the individual taxon level. The LDM can be applied to relative abundance data and presence-absence data separately, which work well when associated taxa are abundant and rare, respectively. Here, we propose LDM-omni3 that combines LDM analyses at the relative abundance and presence-absence data scales, thereby offering optimal power across scenarios with different association mechanisms. The new LDM-omni3 test is available for the wide range of data types and analyses that are supported by the LDM. AVAILABILITY AND IMPLEMENTATION: The LDM-omni3 test has been added to the R package LDM, which is available on GitHub at https://github.com/yijuanhu/LDM. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

We propose CFS, a distributed file system for large scale container platforms. CFS supports both sequential and random file accesses with optimized storage for both large files and small files, and adopts different replication protocols for different write scenarios to improve the replication performance. It employs a metadata subsystem to store and distribute the file metadata across different storage nodes based on the memory usage. This metadata placement strategy avoids the need of data rebalancing during capacity expansion. CFS also provides POSIX-compliant APIs with relaxed semantics and metadata atomicity to improve the system performance. We performed a comprehensive comparison with Ceph, a widely-used distributed file system on container platforms. Our experimental results show that, in testing 7 commonly used metadata operations, CFS gives around 3 times performance boost on average. In addition, CFS exhibits better random-read/write performance in highly concurrent environments with multiple clients and processes.