Drug combinations are essential in cancer therapy, leveraging synergistic drug-drug interactions (DDI) to enhance efficacy and combat resistance. However, the vast combinatorial space makes experimental screening impractical, and existing computational models struggle to capture the complex, bidirectional nature of DDIs, often relying on independent drug encoding or simplistic fusion strategies. To address this, we propose DPASyn, a novel drug synergy prediction framework featuring a dual-attention mechanism and Precision-Aware Quantization (PAQ). The dual-attention architecture jointly models intra-drug structures and inter-drug interactions via shared projections and cross-drug attention, enabling biologically plausible synergy modeling. Our PAQ strategy dynamically optimizes numerical precision during training based on feature sensitivity—reducing memory usage by 40% and accelerating training threefold without sacrificing accuracy. With LayerNorm-stabilized residual connections for stability, DPASyn outperforms seven state-of-the-art methods on the O'Neil dataset (13,243 combinations) [1] and supports full-batch processing of up to 256 graphs on a single GPU—setting a new standard for efficient and expressive drug synergy prediction. The data and source code are available at https://github.com/Echo-Nie/DPASyn.

The 3D point cloud is a common 3D data representation that has received increasing attention for remote sensing applications. However, processing 3D point cloud semantics, especially local semantic information, has always been a challenge and has attracted much attention. In this paper, we propose a novel enhanced local semantic learning transformer for 3D point cloud analysis, which aims to enhance the transformer awareness of local semantic features to handle complex point cloud tasks. First, we propose a novel transformer framework, the local semantic learning point cloud transformer (LSLPCT), which not only learns 3D point clouds the global information, but also enhances the perception of local semantic information end-to-end. Second, we design an efficient local semantic learning self-attention mechanism, namely LSL-SA, which can parallelize the perception of global contextual information and the capture of finer-grained local semantic features. Third, our proposed LSL-SA is easy to implement and can integrate existing transformers and CNN-based networks for processing various point cloud tasks. Numerous experiments in different types of point cloud tasks have been conducted, and our method performs better or is competitive with other state-of-the-art methods.