Electric vehicles offer a pathway to more sustainable transportation, but their adoption entails new challenges not faced by their petroleum-based counterparts. A difficult task in vehicle routing problems addressing these challenges is determining how to make good charging decisions for an electric vehicle traveling a given route. This is known as the fixed route vehicle charging problem. An exact and efficient algorithm for this task exists, but its implementation is sufficiently complex to deter researchers from adopting it. In this work we introduce frvcpy, an open-source Python package implementing this algorithm. Our aim with the package is to make it easier for researchers to solve electric vehicle routing problems, facilitating the development of optimization tools that may ultimately enable the mass adoption of electric vehicles. Summary of Contribution: This work describes a novel software tool for the vehicle routing community. The tool, frvcpy, addresses one of the primary challenges faced by the vehicle routing community when considering problems involving the adoption of electric vehicles (EVs): how to make optimal charging decisions. The state-of-the-art algorithm for solving these problems is sufficiently complex to deter researchers from using it, leading them to adopt less robust methods. frvcpy offers an easy-to-use, lightweight implementation of this algorithm, providing optimal solutions in low (∼5 ms) runtime. It is designed to be easily embedded in larger solution schemes for general EV routing problems, requiring minimal input, offering compatibility with the community standard file types, and offering access both through the command line and a Python API. The tool has thus far proven adaptable, having been used by researchers studying EV routing problems with novel constraints. Our aim with frvcpy is to make it easier for researchers to solve EV routing problems, facilitating the development of optimization tools that may contribute toward the mass adoption of electric vehicles.

SUMMARY: Analysis of HIV-1 virions from participants infected in a randomized controlled preventive HIV-1 vaccine efficacy trial can help elucidate mechanisms of partial protection. By comparing the genetic sequence of viruses from vaccine and placebo recipients to the sequence of the vaccine itself, a technique called 'sieve analysis', one can identify functional specificities of vaccine-induced immune responses. We have created an interactive web-based visualization and data access tool for exploring the results of sieve analyses performed on four major preventive HIV-1 vaccine efficacy trials: (i) the HIV Vaccine Trial Network (HVTN) 502/Step trial, (ii) the RV144/Thai trial, (iii) the HVTN 503/Phambili trial and (iv) the HVTN 505 trial. The tool acts simultaneously as a platform for rapid reinterpretation of sieve effects and as a portal for organizing and sharing the viral sequence data. Access to these valuable datasets also enables the development of novel methodology for future sieve analyses. AVAILABILITY AND IMPLEMENTATION: Visualization: http://sieve.fredhutch.org/viz . Source code: https://github.com/nkullman/SIEVE . Data API: http://sieve.fredhutch.org/data . CONTACT: [email protected].