Different brain diseases are associated with distinct patterns of affected brain regions. Neuroscientists aim to understand the variability of these patterns across different brain diseases. We used a user-centered design approach to develop support for neuroscientists in exploring and comparing which regions are affected by which diseases based on neuroscience literature. Our study involved six neuroscientists and nine visualization experts who evaluated the usability and explainability of our visualization tool for comparing disease patterns in brain regions. Our results show that our tool can help neuroscientists explore and visualize relationships between brain regions and diseases, and compare patterns of affected regions in an immersive AR environment.

Neuroscience researchers are interested in understanding relation between anatomical regions of the brain and disorders that affect them, for example. Using the topics themselves, rather than individual articles, to examine relation in a large body of literature, can provide a higher-level approach. I investigate the use of 3D representations in Augmented Reality to aid neuroscientists to explore literature and understand relations between brain-related topics, given the three-dimensional nature of the brain. Distant reading refers to comprehending the results of studies of a large number of articles, as opposed to the more common ”close reading” of individual publications. For distant reading of neuroscience literature, I identify visualization and interaction design requirements. My assumption is that by providing overviews of the correlations among topics through the use of literature, these will allow neuroscientists to better understand the gaps in the literature and more quickly identify the most suitable experiments to carry out. The DatAR team at Utrecht University has created a prototype 3D AR implementation using which I have carried out two studies of a literature exploration interface. These studies showed that visualizing topics and their relation in an immersive AR environment is clear, understandable and helpful for exploring neuroscience literature. In the following, I will carry out a study that participants can make parallel query and compare the results. I will further investigate in finding indirect relations between brain regions and brain diseases. The last study will support neuroscience students to understand course material. Interface improvements are considering where necessary.

To support scientists in maintaining an overview of disciplinary concepts and their interrelations, we investigate whether Augmented Reality can serve as a platform to make automated methods more accessible and integrated into current literature exploration practices. Building on insights from text and immersive analytics, we identify information and design requirements. We embody these in DatAR, a system design and implementation focussed on analysis of co-occurrences in neuroscientific text collections. We conducted a scenario-based video survey with a sample of neuroscientists and other domain experts, focusing on participants’ willingness to adopt such an AR system in their regular literature review practices. The AR-tailored epistemic and representational designs of our system were generally perceived as suitable for performing complex analytics. We also discuss several fundamental issues with our chosen 3D visualisations, making steps towards understanding in which ways AR is a suitable medium for high-level conceptual literature exploration.