The multi-lead electrocardiogram (ECG) stands as a cornerstone of cardiac diagnosis. Recent strides in electrocardiogram self-supervised learning (eSSL) have brightened prospects for enhancing representation learning without relying on high-quality annotations. Yet earlier eSSL methods suffer a key limitation: they focus on consistent patterns across leads and beats, overlooking the inherent differences in heartbeats rooted in cardiac conduction processes, while subtle but significant variations carry unique physiological signatures. Moreover, representation learning for ECG analysis should align with ECG diagnostic guidelines, which progress from individual heartbeats to single leads and ultimately to lead combinations. This sequential logic, however, is often neglected when applying pre-trained models to downstream tasks. To address these gaps, we propose CLEAR-HUG, a two-stage framework designed to capture subtle variations in cardiac conduction across leads while adhering to ECG diagnostic guidelines. In the first stage, we introduce an eSSL model termed Conduction-LEAd Reconstructor (CLEAR), which captures both specific variations and general commonalities across heartbeats. Treating each heartbeat as a distinct entity, CLEAR employs a simple yet effective sparse attention mechanism to reconstruct signals without interference from other heartbeats. In the second stage, we implement a Hierarchical lead-Unified Group head (HUG) for disease diagnosis, mirroring clinical workflow. Experimental results across six tasks show a 6.84% improvement, validating the effectiveness of CLEAR-HUG. This highlights its ability to enhance representations of cardiac conduction and align patterns with expert diagnostic guidelines.

Out-of-Distribution (OOD) detection is essential for the trustworthiness of AI systems. Methods using prior information (i.e., subspace-based methods) have shown effective performance by extracting information geometry to detect OOD data with a more appropriate distance metric. However, these methods fail to address the geometry distorted by ill-distributed samples, due to the limitation of statically extracting information geometry from the training distribution. In this paper, we argue that the influence of ill-distributed samples can be corrected by dynamically adjusting the prior geometry in response to new data. Based on this insight, we propose a novel approach that dynamically updates the prior covariance matrix using real-time input features, refining its information. Specifically, we reduce the covariance along the direction of real-time input features and constrain adjustments to the residual space, thus preserving essential data characteristics and avoiding effects on unintended directions in the principal space. We evaluate our method on two pre-trained models for the CIFAR dataset and five pre-trained models for ImageNet-1k, including the self-supervised DINO model. Extensive experiments demonstrate that our approach significantly enhances OOD detection across various models. The code is released at https://github.com/workerbcd/ooddcc.

The generalization ability of deep learning has been extensively studied in supervised settings, yet it remains less explored in unsupervised scenarios. Recently, the Unsupervised Domain Generalization (UDG) task has been proposed to enhance the generalization of models trained with prevalent unsupervised learning techniques, such as Self-Supervised Learning (SSL). UDG confronts the challenge of distinguishing semantics from variations without category labels. Although some recent methods have employed domain labels to tackle this issue, such domain labels are often unavailable in real-world contexts. In this paper, we address these limitations by formalizing UDG as the task of learning a Minimal Sufficient Semantic Representation: a representation that (i) preserves all semantic information shared across augmented views (sufficiency), and (ii) maximally removes information irrelevant to semantics (minimality). We theoretically ground these objectives from the perspective of information theory, demonstrating that optimizing representations to achieve sufficiency and minimality directly reduces out-of-distribution risk. Practically, we implement this optimization through Minimal-Sufficient UDG (MS-UDG), a learnable model by integrating (a) an InfoNCE-based objective to achieve sufficiency; (b) two complementary components to promote minimality: a novel semantic-variation disentanglement loss and a reconstruction-based mechanism for capturing adequate variation. Empirically, MS-UDG sets a new state-of-the-art on popular unsupervised domain-generalization benchmarks, consistently outperforming existing SSL and UDG methods, without category or domain labels during representation learning.

Computed tomography (CT) imaging, characterized by its high contrast sensitivity and spatial resolution, provides detailed insights into a patient’s internal anatomical structures, particularly the intricate details of the spinal vertebrae. Compared to conventional X-ray imaging, CT scans entail higher radiation exposure and increased costs. The reconstruction of three-dimensional CT images and precise spinal models from two-dimensional X-ray images has garnered clinical interest due to lower radiation risks and improved accessibility. Inspired by self-supervised learning principles, this study introduces a novel self-guided cross-domain learning approach, SGX2CT, aimed at simultaneously reconstructing three-dimensional lumbar CT scans and spinal models from two-dimensional X-rays while facilitating mutual reinforcement. Specifically, a multi-domain shared generator is employed to acquire robust global information, coupled with perceptual loss functions for alignment in image space. Domain-specific group normalization is utilized to disentangle distinct features across domains to enhance outcomes in each domain. Experimental findings demonstrate that SGX2CT achieves state-of-the-art performance in both lumbar CT reconstruction and spinal model generation, underscoring its potential utility in orthopedic practice.

Deep learning models often suffer from catastrophic forgetting when fine-tuned with samples of new classes. This issue becomes even more challenging when there is a domain shift between training and testing data. In this paper, we address the critical yet less explored Domain-Generalized Class-Incremental Learning (DGCIL) task. We propose a DGCIL approach designed to memorize old classes, adapt to new classes, and reliably classify objects from unseen domains. Specifically, our loss formulation maintains classification boundaries while suppressing domain-specific information for each class. Without storing old exemplars, we employ knowledge distillation and estimate the drift of old class prototypes as incremental training progresses. Our prototype representations are based on multivariate Normal distributions , with means and covariances continually adapted to reflect evolving model features, providing effective representations for old classes. We then sample pseudo-features for these old classes from the adapted Normal distributions using Cholesky decomposition . Unlike previous pseudo-feature sampling strategies that rely solely on average mean prototypes, our method captures richer semantic variations. Experiments on several benchmarks demonstrate the superior performance of our method compared to the state of the art.