MOTIVATION: Accurate prediction of adverse drug reactions (ADRs) is essential for drug safety surveillance, and recent advances in machine learning with heterogeneous biomedical information have improved predictive performance. However, two challenges remain: current methods often learn inadequate ADR representations that fail to capture dependencies among ADRs, and generalize poorly to novel drugs. RESULTS: To obtain informative ADR embeddings, we construct a multi-source, multi-relational ADR graph that integrates hierarchical structure and empirical ADR co-occurrence, and apply a relational graph convolutional network (R-GCN) to learn relation-aware ADR representations. To enhance generalization to novel drugs, we exploit the hierarchical structure of the Anatomical Therapeutic Chemical (ATC) classification to link drugs via shared higher-level categories for effective knowledge transfer and model these relations with an R-GCN. We further introduce a Conditional Domain Adversarial Network (CDAN) to reduce distribution shifts between known and novel drugs by aligning features conditioned on predicted ADR labels, learning domain-invariant yet task-relevant representations. Additionally, to exploit similar ADR patterns among related drugs, we introduce a dual-branch mixture-of-experts (Dual-MoE) module where each expert captures ADR commonalities within a drug category in one branch, while a separate branch models global patterns. Extensive experiments show that our method consistently outperforms seven baselines, achieving F1 improvements of 4.3% and 4.7% over the best baseline on two datasets, respectively, with more balanced precision-recall trade-offs. It also improves AUC on uncommon ADRs by 7% more than on common ADRs, and remains more robust under data sparsity, with more gradual performance degradation as training data decreases. AVAILABILITY AND IMPLEMENTATION: The code of our model is available at https://github.com/fzsdb/Knowledge-guided-ADR-prediction.git.

Automated captioning for remote sensing imagery often struggles to balance the high descriptive power of large models with the deployment feasibility of smaller ones. To bridge this gap, this paper introduces ONIR, a LLM-efficient, tag-guided framework that empowers compact language models (1-3B parameters) to achieve state-of-the-art captioning accuracy. Specifically, the proposed approach synthesizes a large-scale pseudo-caption dataset by leveraging GPT-4O on existing segmentation benchmarks. Explicit semantic tags are then extracted to train a multi-label Contrastive Language-Image Pre-Training (CLIP) encoder, providing interpretable visual guidance. To maintain parameter efficiency, the architecture incorporates a simple Multilayer Perceptron (MLP) bridge and a two-stage LoRA fine-tuning strategy. Extensive experiments on standard benchmark dataset, such as UCM and Sydney Captions, demonstrate that ONIR significantly outperforms models up to four times its size (7-13B). By combining superior performance with computational efficiency and tag-based controllability, ONIR offers a highly practical solution for real-world remote sensing applications.

Recently, vision-language models (e.g. CLIP) have demonstrated remarkable performance in zero-shot anomaly detection (ZSAD). By leveraging auxiliary data during training, these models can directly perform cross-category anomaly detection on target datasets, such as detecting defects on industrial product surfaces or identifying tumors in organ tissues. Existing approaches typically construct text prompts through either manual design or the optimization of learnable prompt vectors. However, these methods face several challenges: 1) handcrafted prompts require extensive expert knowledge and trial-and-error; 2) single-form learnable prompts struggle to capture complex anomaly semantics; and 3) an unconstrained prompt space limits generalization to unseen categories. To address these issues, we propose Bayesian Prompt Flow Learning (Bayes-PFL), which models the prompt space as a learnable probability distribution from a Bayesian perspective. Specifically, a prompt flow module is designed to learn both image-specific and image-agnostic distributions, which are jointly utilized to regularize the text prompt space and improve the model's generalization on unseen categories. These learned distributions are then sampled to generate diverse text prompts, effectively covering the prompt space. Additionally, a residual cross-model attention (RCA) module is introduced to better align dynamic text embeddings with fine-grained image features. Extensive experiments on 15 industrial and medical datasets demonstrate our method's superior performance. The code is available at https://github.com/xiaozhen228/Bayes-PFL.

Recent vision-language models (e.g., CLIP) have demonstrated remarkable class-generalizable ability to unseen classes in few-shot anomaly segmentation (FSAS), leveraging supervised prompt learning or fine-tuning on seen classes. However, their cross-category generalization largely depends on prior knowledge of real seen anomaly samples. In this paper, we propose a novel framework, namely DictAS, which enables a unified model to detect visual anomalies in unseen object categories without any retraining on the target data, only employing a few normal reference images as visual prompts. The insight behind DictAS is to transfer dictionary lookup capabilities to the FSAS task for unseen classes via self-supervised learning, instead of merely memorizing the normal and abnormal feature patterns from the training set. Specifically, DictAS mainly consists of three components: (1) Dictionary Construction - to simulate the index and content of a real dictionary using features from normal reference images. (2) Dictionary Lookup - to retrieve queried region features from the dictionary via a sparse lookup strategy. When a query feature cannot be retrieved, it is classified as an anomaly. (3) Query Discrimination Regularization - to enhance anomaly discrimination by making abnormal features harder to retrieve from the dictionary. To achieve this, Contrastive Query Constraint and Text Alignment Constraint are further proposed. Extensive experiments on seven public industrial and medical datasets demonstrate that DictAS consistently outperforms state-of-the-art FSAS methods.

Modern engineering, spanning electrical, mechanical, aerospace, civil, and computer disciplines, stands as a cornerstone of human civilization and the foundation of our society. However, engineering design poses a fundamentally different challenge for large language models (LLMs) compared with traditional textbook-style problem solving or factual question answering. Although existing benchmarks have driven progress in areas such as language understanding, code synthesis, and scientific problem solving, real-world engineering design demands the synthesis of domain knowledge, navigation of complex trade-offs, and management of the tedious processes that consume much of practicing engineers' time. Despite these shared challenges across engineering disciplines, no benchmark currently captures the unique demands of engineering design work. In this work, we introduce EngDesign, an Engineering Design benchmark that evaluates LLMs' abilities to perform practical design tasks across nine engineering domains. Unlike existing benchmarks that focus on factual recall or question answering, EngDesign uniquely emphasizes LLMs' ability to synthesize domain knowledge, reason under constraints, and generate functional, objective-oriented engineering designs. Each task in EngDesign represents a real-world engineering design problem, accompanied by a detailed task description specifying design goals, constraints, and performance requirements. EngDesign pioneers a simulation-based evaluation paradigm that moves beyond textbook knowledge to assess genuine engineering design capabilities and shifts evaluation from static answer checking to dynamic, simulation-driven functional verification, marking a crucial step toward realizing the vision of engineering Artificial General Intelligence (AGI).

Multi-unmanned aerial vehicle (UAV) cooperative maritime object recognition aims to maintain high accuracy under dynamic aerial perspectives for maritime search and rescue missions. Existing continual learning methods retain knowledge by approximating the global distribution of prior data but fail to address cross-perspective knowledge conflicts caused by distribution shifts across aerial perspectives, leading to gradient perturbations that harm consistency and accuracy in dynamic maritime environments. To address the issues, we propose a conflict-modulated generative continual learning (ConMod) framework, comprising generative perspective-robust conflict estimation and conflict-modulated continual learning modules. The generative perspective-robust conflict estimation employs a perspective-aware scene generator that embeds maritime knowledge priors as perspective constraints to augment the data distribution, thereby facilitating explainable cross-perspective conflict association and promoting robust conflict index estimation. It also incorporates a dual-modal conflict index estimator that integrates geometric distortion and environmental variation branches to estimate conflict indices by associating simulated scenes with perspective-robust data distributions. Furthermore, conflict-modulated continual learning introduces a perspective-specific triplet loss to regularize consistency by aligning geometric and environmental features within perspective-specific representation space. Additionally, a conflict-modulated loss treats conflict indices as modulation weights to identify and reinforce representative conflict experiences from a cross-perspective memory buffer, guiding gradient updates toward global optimization. Results on the SeaDronesSee-CL and SeaDronesSee-CL-v2 datasets show that ConMod effectively improves multi-UAV cooperative maritime object recognition by identifying and mitigating cross-perspective knowledge conflicts.

Auxiliary information, such as knowledge graph (KG), has become increasingly crucial in recommender systems. However, the current KG-based recommendation still has some limitations: (1) low link rates between items and KG entities, (2) redundant knowledge in KG. In this paper, we introduce the aspect, which refers to keywords describing item attributes in reviews, to KG-based recommendation, and propose a new model, Collaborative Aspect Graph enhanced Knowledge-based Network (CAGK). Firstly, CAGK builds a Collaborative Aspect Graph (CAG) with user-item interactions, aspects and KG, where aspects can fill most of the sparsity. Secondly, we leverage interactive information and aspect features to generate aspect-aware guidance signals to customize knowledge extraction and eliminate redundant knowledge. Lastly, we utilize low ratings and negative aspect sentiment to capture features of that users dislike to prevent repetitive recommendations of disliked items. Experimental results on two widely used benchmark datasets, Amazon-book and Yelp2018, confirm the superiority of CAGK.

This article focuses on automatic inspection for the commonly used component called spring-wire socket. An automatic inspection system is built that adopts an endoscope to improve the imaging quality. To detect the low contrast targets in complex background, we adopt the pipeline of Faster R-CNN but with several improvements. The improved network specifies the targets in the form of quadrangular bounding box as opposed to previous methods that specify them by rectangular bounding box. With the quadrangular representation, additional shape and pose information is provided and unexpected overlaps and background disturbance could be avoided. In the network, an eight-dimensional (8-D) vector is designed to represent the quadrangular bounding box followed by the improved anchor mechanism in the region proposal network. And also, a novel overlap score calculation method is proposed. On the basis of the detection result, rules arisen from expertise are provided to determine the quality of the component in which way automatic quality inspection could be accomplished. The superiority of our detection network over existing ones is sufficiently demonstrated with the detection result of irregular targets in images captured in the industrial scenario. Meanwhile, successful inspection result proves that the system meets the industrial requirements in terms of both accuracy and speed and thus is of practical significance to industrial applications.