When we perform a cognitive task, multiple brain regions are engaged. Understanding how these regions interact is a fundamental step to uncover the neural bases of behavior. Most research on the interactions between brain regions has focused on the univariate responses in the regions. However, fine grained patterns of response encode important information, as shown by multivariate pattern analysis. In the present article, we introduce and apply multivariate pattern dependence (MVPD): a technique to study the statistical dependence between brain regions in humans in terms of the multivariate relations between their patterns of responses. MVPD characterizes the responses in each brain region as trajectories in region-specific multidimensional spaces, and models the multivariate relationship between these trajectories. We applied MVPD to the posterior superior temporal sulcus (pSTS) and to the fusiform face area (FFA), using a searchlight approach to reveal interactions between these seed regions and the rest of the brain. Across two different experiments, MVPD identified significant statistical dependence not detected by standard functional connectivity. Additionally, MVPD outperformed univariate connectivity in its ability to explain independent variance in the responses of individual voxels. In the end, MVPD uncovered different connectivity profiles associated with different representational subspaces of FFA: the first principal component of FFA shows differential connectivity with occipital and parietal regions implicated in the processing of low-level properties of faces, while the second and third components show differential connectivity with anterior temporal regions implicated in the processing of invariant representations of face identity.

We present a Bayesian framework for explaining how people reason about and predict the actions of an intentional agent, based on observ- ing its behavior. Action-understanding is cast as a problem of inverting a probabilistic generative model, which assumes that agents tend to act rationally in order to achieve their goals given the constraints of their en- vironment. Working in a simple sprite-world domain, we show how this model can be used to infer the goal of an agent and predict how the agent will act in novel situations or when environmental constraints change. The model provides a qualitative account of several kinds of inferences that preverbal infants have been shown to perform, and also fits quantita- tive predictions that adult observers make in a new experiment.