A problem is \emph{downward self-reducible} if it can be solved efficiently given an oracle that returns solutions for strictly smaller instances. In the decisional landscape, downward self-reducibility is well studied and it is known that all downward self-reducible problems are in \textsc{PSPACE}. In this paper, we initiate the study of downward self-reducible search problems which are guaranteed to have a solution -- that is, the downward self-reducible problems in \textsc{TFNP}. We show that most natural $\PLS$-complete problems are downward self-reducible and any downward self-reducible problem in \textsc{TFNP} is contained in \textsc{PLS}. Furthermore, if the downward self-reducible problem is in \textsc{TFUP} (i.e. it has a unique solution), then it is actually contained in \textsc{UEOPL}, a subclass of \textsc{CLS}. This implies that if integer factoring is \emph{downward self-reducible} then it is in fact in \textsc{UEOPL}, suggesting that no efficient factoring algorithm exists using the factorization of smaller numbers.

We revisit the planning problem in the blocks world, and we implement a known heuristic for this task. Importantly, our implementation is biologically plausible, in the sense that it is carried out exclusively through the spiking of neurons. Even though much has been accomplished in the blocks world over the past five decades, we believe that this is the first algorithm of its kind. The input is a sequence of symbols encoding an initial set of block stacks as well as a target set, and the output is a sequence of motion commands such as "put the top block in stack 1 on the table". The program is written in the Assembly Calculus, a recently proposed computational framework meant to model computation in the brain by bridging the gap between neural activity and cognitive function. Its elementary objects are assemblies of neurons (stable sets of neurons whose simultaneous firing signifies that the subject is thinking of an object, concept, word, etc.), its commands include project and merge, and its execution model is based on widely accepted tenets of neuroscience. A program in this framework essentially sets up a dynamical system of neurons and synapses that eventually, with high probability, accomplishes the task. The purpose of this work is to establish empirically that reasonably large programs in the Assembly Calculus can execute correctly and reliably; and that rather realistic --- if idealized --- higher cognitive functions, such as planning in the blocks world, can be implemented successfully by such programs.

We identify several genres of search problems beyond NP for which existence of solutions is guaranteed. One class that seems especially rich in such problems is PEPP (for "polynomial empty pigeonhole principle"), which includes problems related to existence theorems proved through the union bound, such as finding a bit string that is far from all codewords, finding an explicit rigid matrix, as well as a problem we call Complexity, capturing Complexity Theory’s quest. When the union bound is generous, in that solutions constitute at least a polynomial fraction of the domain, we have a family of seemingly weaker classes α-PEPP, which are inside FP^NP|poly. Higher in the hierarchy, we identify the constructive version of the Sauer-Shelah lemma and the appropriate generalization of PPP that contains it, as well as the problem of finding a king in a tournament (a vertex k such that all other vertices are defeated by k, or by somebody k defeated).