Convolutional neural networks (CNNs) play a key role in deep learning applications. However, the large storage overheads and the substantial computational cost of CNNs are problematic in hardware accelerators. Computing-in-memory (CIM) architecture has demonstrated great potential to effectively compute large-scale matrix–vector multiplication. However, the intensive multiply and accumulation (MAC) operations executed on CIM macros remain bottlenecks for further improvement of energy efficiency and throughput. To reduce computational costs, model compression is a widely studied method to shrink the model size. For implementation in a static random access memory (SRAM) CIM–based accelerator, the model compression algorithm must consider the hardware limitations of CIM macros. In this study, a software and hardware co-design approach is proposed to design MARS, a SRAM-based CIM (SRAM CIM)-based CNN accelerator that can utilize multiple SRAM CIM macros as processing units and support a sparse CNN, and an SRAM CIM-aware model compression algorithm that considers a CIM architecture to reduce the number of network parameters. With the proposed hardware software co-designed method, MARS can reach over 700 and 400 FPS for CIFAR-10 and CIFAR-100, respectively. In addition, MARS achieves 52.3 and 88.2 TOPs/W in VGG16 and ResNet18, respectively.