Surround suppression (SS) is a fundamental property of sensory processing throughout the brain. In the auditory system, the early processing stream encodes sounds using a one dimensional physical space-frequency. Previous studies in the auditory system have shown SS to manifest as bandwidth tuning around the preferred frequency. We asked whether bandwidth tuning can be found around frequencies away from the preferred frequency. We exploited the simplicity of spectral representation of sounds to study SS by manipulating both sound frequency and bandwidth. We recorded single unit spiking activity from the auditory cortex (ACx) of awake mice in response to an array of broadband stimuli with varying central frequencies and bandwidths. Our recordings revealed that a significant portion of neuronal response profiles had a preferred bandwidth that varied in a regular way with the sound's central frequency. To gain insight into the possible mechanism underlying these responses, we modelled neuronal activity using a variation of the "Mexican hat" function often used to model SS. The model accounted for response properties of single neurons with high accuracy. Our data and model show that these responses in ACx obey simple rules resulting from the presence of lateral inhibitory sidebands, mostly above the excitatory band of the neuron, that result in sensitivity to the location of top frequency edges, invariant to other spectral attributes. Our work offers a simple explanation for auditory edge detection and possibly other computations of spectral content in sounds.

The attentional blink (AB) effect is the reduced probability of reporting a second target (T2) that appears shortly after a first one (T1) within a rapidly presented sequence of distractors. The AB effect has been shown to be reduced following intensive mental training in the form of mindfulness meditation, with a corresponding reduction in T1-evoked P3b brain potentials. However, the mechanisms underlying these effects remain unknown. We propose a dynamical-systems model of the AB, in which attentional load is described as the response of a dynamical system to incoming impulse signals. Non-task related mental activity is represented by additive noise modulated by meditation. The model provides a parsimonious computational framework relating behavioral performance, evoked brain potentials and training through the concept of reduced mental noise.

The perception of sound in real-life acoustic environments, such as enclosed rooms or open spaces with reflective objects, is affected by reverberation. Hence, reverberation is extensively studied in the context of auditory perception, with many studies highlighting the importance of the direct sound for perception. Based on this insight, speech processing methods often use time-frequency (TF) analysis to detect TF bins that are dominated by the direct sound, and then use the detected bins to reproduce or enhance the speech signals. The detection of bins dominated by the direct sound is typically based on an objective measure, such as the direct-to-reverberant ratio (DRR). However, the relation between the DRR in the TF bins and the spatial perception of the reverberant sound which is reproduced from these bins is still not clear. It is the aim of this paper to provide some insights into this relation, specifically for reverberant speech, focusing on bins with high DRR. This is performed using a listening experiment, where high DRR bins within a reverberant speech signal have been masked in the TF domain, based on various DRR thresholds. The results show that the percentage of high-DRR TF bins that were masked may better indicate the quality of spatial perception, compared to the specific value of the DRR threshold. The insights from this work could be incorporated into spatial audio techniques that reproduce the direct sound of reverberant speech, and potentially improve spatial perception. This was illustrated with an implementation of directional audio coding that was studied with an additional listening experiment supporting the previously described results.

We introduce a novel methodology for describing animal behavior as a tradeoff between value and complexity, using the Morris Water Maze navigation task as a concrete example. We develop a dynamical system model of the Water Maze navigation task, solve its optimal control under varying complexity constraints, and analyze the learning process in terms of the value and complexity of swimming trajectories. The value of a trajectory is related to its energetic cost and is correlated with swimming time. Complexity is a novel learning metric which measures how unlikely is a trajectory to be generated by a naive animal. Our model is analytically tractable, provides good fit to observed behavior and reveals that the learning process is characterized by early value optimization followed by complexity reduction. Furthermore, complexity sensitively characterizes behavioral differences between mouse strains.

Stimulus-specific adaptation (SSA) occurs when neurons decrease their responses to frequently-presented (standard) stimuli but not, or not as much, to other, rare (deviant) stimuli. SSA is present in all mammalian species in which it has been tested as well as in birds. SSA confers short-term memory to neuronal responses, and may lie upstream of the generation of mismatch negativity (MMN), an important human event-related potential. Previously published models of SSA mostly rely on synaptic depression of the feedforward, thalamocortical input. Here we study SSA in a recurrent neural network model of primary auditory cortex. When the recurrent, intracortical synapses display synaptic depression, the network generates population spikes (PSs). SSA occurs in this network when deviants elicit a PS but standards do not, and we demarcate the regions in parameter space that allow SSA. While SSA based on PSs does not require feedforward depression, we identify feedforward depression as a mechanism for expanding the range of parameters that support SSA. We provide predictions for experiments that could help differentiate between SSA due to synaptic depression of feedforward connections and SSA due to synaptic depression of recurrent connections. Similar to experimental data, the magnitude of SSA in the model depends on the frequency difference between deviant and standard, probability of the deviant, inter-stimulus interval and input amplitude. In contrast to models based on feedforward depression, our model shows true deviance sensitivity as found in experiments.

To survive, organisms must extract information from the past that is relevant for their future. How this process is expressed at the neural level remains unclear. We address this problem by developing a novel approach from first principles. We show here how to generate low-complexity representations of the past that produce optimal predictions of future events. We then illustrate this framework by studying the coding of 'oddball' sequences in auditory cortex. We find that for many neurons in primary auditory cortex, trial-by-trial fluctuations of neuronal responses correlate with the theoretical prediction error calculated from the short-term past of the stimulation sequence, under constraints on the complexity of the representation of this past sequence. In some neurons, the effect of prediction error accounted for more than 50% of response variability. Reliable predictions often depended on a representation of the sequence of the last ten or more stimuli, although the representation kept only few details of that sequence.

Probabilistic modeling of temporal phenomena is of central importance in a variety of fields ranging from neuroscience to economics to speech recognition. While the task has received extensive attention in recent decades, learning temporal models for multivariate real-valued data that is non-Gaussian is still a formidable challenge. Recently, the power of copulas, a framework for representing complex multi-modal and heavy-tailed distributions, was fused with the formalism of Bayesian networks to allow for flexible modeling of high-dimensional distributions. In this work we introduce Dynamic Copula Bayesian Networks, a generalization aimed at capturing the distribution of rich temporal sequences. We apply our model to three markedly different real-life domains and demonstrate substantial quantitative and qualitative advantage.

We tackle the task of localizing speech signals on the horizontal plane using monaural cues. We show that monaural cues as incorporated in speech are efficiently captured by amplitude modulation spectra patterns. We demonstrate that by using these patterns, a linear Support Vector Machine can use directionality related information to learn to discriminate and classify sound location at high resolution. We propose a straightforward and robust way of integrating information from two ears: treating each ear as an independent processor and integrate the information at the decision level by doing that ambiguity is to a large extent resolved.

We present a novel approach to the characterization of complex sensory neurons. One of the main goals of characterizing sensory neurons is to characterize dimensions in stimulus space to which the neurons are highly sensitive (causing large gradients in the neural responses) or al- ternatively dimensions in stimulus space to which the neuronal response are invariant (defining iso-response manifolds). We formulate this prob- lem as that of learning a geometry on stimulus space that is compatible with the neural responses: the distance between stimuli should be large when the responses they evoke are very different, and small when the re- sponses they evoke are similar. Here we show how to successfully train such distance functions using rather limited amount of information. The data consisted of the responses of neurons in primary auditory cortex (A1) of anesthetized cats to 32 stimuli derived from natural sounds. For each neuron, a subset of all pairs of stimuli was selected such that the responses of the two stimuli in a pair were either very similar or very dissimilar. The distance function was trained to fit these constraints. The resulting distance functions generalized to predict the distances between the responses of a test stimulus and the trained stimuli.

The way groups of auditory neurons interact to code acoustic in(cid:173) formation is investigated using an information theoretic approach. We develop measures of redundancy among groups of neurons, and apply them to the study of collaborative coding efficiency in two processing stations in the auditory pathway: the inferior colliculus (IC) and the primary auditory cortex (AI). Under two schemes for the coding of the acoustic content, acoustic segments coding and stimulus identity coding, we show differences both in information content and group redundancies between IC and AI neurons. These results provide for the first time a direct evidence for redundancy reduction along the ascending auditory pathway, as has been hy(cid:173) pothesized for theoretical considerations [Barlow 1959,2001]. The redundancy effects under the single-spikes coding scheme are signif(cid:173) icant only for groups larger than ten cells, and cannot be revealed with the redundancy measures that use only pairs of cells. The results suggest that the auditory system transforms low level rep(cid:173) resentations that contain redundancies due to the statistical struc(cid:173) ture of natural stimuli, into a representation in which cortical neu(cid:173) rons extract rare and independent component of complex acoustic signals, that are useful for auditory scene analysis.

The goal of most learning processes is to bring a machine into a set of "correct" states. In practice, however, it may be difficult to show that the process enters this target set. We present a condition that ensures that the process visits the target set infinitely often almost surely. This condition is easy to verify and is true for many well-known learning rules. To demonstrate the utility of this method, we apply it to four types of learning processes: the perceptron, learning rules governed by continuous energy functions, the Kohonen rule, and the committee machine.

We present results from an ongoing electrophysiological study of cortical function in the awake, behaving monkey. Single and multiple neuron activity is recorded from the frontal cortex, while the monkey is engaged in a sensory-motor association task. Results show that neighboring neurons in the frontal cortex may be functionally related and share common features. However, even when neurons were reduced by the same microelectrode, they were not all activated in unison, nor did they all show the same functional properties. Correlation analysis reveals that interactions between neurons may strongly depend on stimulus context and/or behavioral state. Moreover, the interactions may be highly dynamic, with time constants of modulation as low as tens of milliseconds. These findings point at the need to distinguish between anatomical connectivity and functional coupling. The underlying mechanisms as well as the functional implications of such dynamic coupling in cortical networks are discussed.