OBJECTIVE: To introduce 2 R-packages that facilitate conducting health economics research on OMOP-based data networks, aiming to standardize and improve the reproducibility, transparency, and transferability of health economic models. MATERIALS AND METHODS: We developed the software tools and demonstrated their utility by replicating a UK-based heart failure data analysis across 5 different international databases from Estonia, Spain, Serbia, and the United States. RESULTS: We examined treatment trajectories of 47 163 patients. The overall incremental cost-effectiveness ratio (ICER) for telemonitoring relative to standard of care was 57 472 €/QALY. Country-specific ICERs were 60 312 €/QALY in Estonia, 58 096 €/QALY in Spain, 40 372 €/QALY in Serbia, and 90 893 €/QALY in the US, which surpassed the established willingness-to-pay thresholds. DISCUSSION: Currently, the cost-effectiveness analysis lacks standard tools, is performed in ad-hoc manner, and relies heavily on published information that might not be specific for local circumstances. Published results often exhibit a narrow focus, central to a single site, and provide only partial decision criteria, limiting their generalizability and comprehensive utility. CONCLUSION: We created 2 R-packages to pioneer cost-effectiveness analysis in OMOP CDM data networks. The first manages state definitions and database interaction, while the second focuses on Markov model learning and profile synthesis. We demonstrated their utility in a multisite heart failure study, comparing telemonitoring and standard care, finding telemonitoring not cost-effective.

Abstract Artificial intelligence (AI) permeates all fields of life, which resulted in new challenges in requirements engineering for artificial intelligence (RE4AI), e.g., the difficulty in specifying and validating requirements for AI or considering new quality requirements due to emerging ethical implications. It is currently unclear if existing RE methods are sufficient or if new ones are needed to address these challenges. Therefore, our goal is to provide a comprehensive overview of RE4AI to researchers and practitioners. What has been achieved so far, i.e., what practices are available, and what research gaps and challenges still need to be addressed? To achieve this, we conducted a systematic mapping study combining query string search and extensive snowballing. The extracted data was aggregated, and results were synthesized using thematic analysis. Our selection process led to the inclusion of 126 primary studies. Existing RE4AI research focuses mainly on requirements analysis and elicitation, with most practices applied in these areas. Furthermore, we identified requirements specification, explainability, and the gap between machine learning engineers and end-users as the most prevalent challenges, along with a few others. Additionally, we proposed seven potential research directions to address these challenges. Practitioners can use our results to identify and select suitable RE methods for working on their AI-based systems, while researchers can build on the identified gaps and research directions to push the field forward.

Abstract The domain of cyber‐physical systems (CPS) has recently seen strong growth, for example, due to the rise of the Internet of Things (IoT) in industrial domains, commonly referred to as “Industry 4.0.” However, CPS challenges like the strong hardware focus can impact modern software development practices, especially in the context of modernizing legacy systems. While microservices and DevOps have been widely studied for enterprise applications, there is insufficient coverage for the CPS domain. Our goal is therefore to analyze the peculiarities of such systems regarding challenges and practices for using and migrating towards microservices and DevOps. We conducted a rapid review based on 146 scientific papers, and subsequently validated our findings in an interview‐based case study with nine CPS professionals in different business units at Siemens AG. The combined results picture the specifics of microservices and DevOps in the CPS domain. While several differences were revealed that may require adapted methods, many challenges and practices are shared with typical enterprise applications. Our study supports CPS researchers and practitioners with a summary of challenges, practices to address them, and research opportunities.

AI-based software systems have seen more widespread production deployment in recent years. However, many challenges currently complicate the integration of AI-based software components into production systems, and their operation and maintenance remains complex. In this research proposal, we summarize these challenges and propose a framework that enables the efficient design, integration, and operation of AI components.