Abstract The limited availability of 3D medical image datasets, due to privacy concerns and high collection or annotation costs, poses significant challenges in the field of medical imaging. There are few solutions for realistic 3D medical image synthesis due to difficulties in backbone design and fewer 3D training samples compared to 2D counterparts. In this paper, we propose GEM-3D , a novel generative approach to the synthesis of 3D medical images and the enhancement of existing datasets using conditional diffusion models. Our method begins with a 2D slice, noted as the informed slice to serve the patient prior, and propagates the generation process using a 3D segmentation mask. By decomposing the 3D medical images into editable masks and patient prior information, GEM-3D offers a flexible yet effective solution for generating versatile 3D images from existing datasets. Moreover, as the informed slice contains patient-wise information, GEM-3D can also facilitate counterfactual image synthesis and dataset-level de-enhancement with desired control. Experiments on brain MRI and abdomen CT images demonstrate that GEM-3D is capable of synthesizing high-quality 3D medical images with volumetric consistency, offering a straightforward solution for dataset enhancement during inference. The code is available at https://github.com/HKU-MedAI/GEM-3D .

Current methods for 3D generation still fall short in physically based rendering (PBR) texturing, primarily due to limited data and challenges in modeling multi-channel materials. In this work, we propose MuMA, a method for 3D PBR texturing through Multi-channel Multi-view generation and Albedo post-processing. Our approach features two key innovations: 1) we opt to model shaded and albedo appearance channels, where the shaded channels enables the integration intrinsic decomposition modules for material properties; and 2) leveraging multimodal large language models, we emulate artists' techniques for material assessment and selection. Experiments demonstrate that MuMA achieves superior results in visual quality and material fidelity compared to existing methods.

Customized text-to-video generation aims to generate high-quality videos guided by text prompts and subject references. Current approaches for personalizing text-to-video generation suffer from tackling multiple subjects, which is a more challenging and practical scenario. In this work, our aim is to promote multi-subject guided text-to-video customization. We propose CustomVideo, a novel framework that can generate identity-preserving videos with the guidance of multiple subjects. To be specific, firstly, we encourage the co-occurrence of multiple subjects via composing them in a single image. Further, upon a basic text-to-video diffusion model, we design a simple yet effective attention control strategy to disentangle different subjects in the latent space of diffusion model. Moreover, to help the model focus on the specific area of the object, we segment the object from given reference images and provide a corresponding object mask for attention learning. Also, we collect a multi-subject text-to-video generation dataset as a comprehensive benchmark. Extensive qualitative, quantitative, and user study results demonstrate the superiority of our method compared to previous state-of-the-art approaches.

While Implicit Neural Representations (INRs) have demonstrated significant success in image representation, they are often hindered by large training memory and slow decoding speed. Recently, Gaussian Splatting (GS) has emerged as a promising solution in 3D reconstruction due to its highquality novel view synthesis and rapid rendering capabilities, positioning it as a valuable tool for a broad spectrum of applications. In particular, a GS-based representation, 2DGS, has shown potential for image fitting. In our work, we present Large Images are Gaussians (LIG), which delves deeper into the application of 2DGS for image representations, addressing the challenge of fitting large images with 2DGS in the situation of numerous Gaussian points, through two distinct modifications: 1) we adopt a variant of representation and optimization strategy, facilitating the fitting of a large number of Gaussian points; 2) we propose a Level-of-Gaussian approach for reconstructing both coarse low-frequency initialization and fine high-frequency details. Consequently, we successfully represent large images as Gaussian points and achieve high-quality large image representation, demonstrating its efficacy across various types of large images.

Recent advances in auto-regressive transformers have revolutionized generative modeling across different domains, from language processing to visual generation, demonstrating remarkable capabilities. However, applying these advances to 3D generation presents three key challenges: the unordered nature of 3D data conflicts with sequential next-token prediction paradigm, conventional vector quantization approaches incur substantial compression loss when applied to 3D meshes, and the lack of efficient scaling strategies for higher resolution latent prediction. To address these challenges, we introduce MAR-3D, which integrates a pyramid variational autoencoder with a cascaded masked auto-regressive transformer (Cascaded MAR) for progressive latent upscaling in the continuous space. Our architecture employs random masking during training and auto-regressive denoising in random order during inference, naturally accommodating the unordered property of 3D latent tokens. Additionally, we propose a cascaded training strategy with condition augmentation that enables efficiently up-scale the latent token resolution with fast convergence. Extensive experiments demonstrate that MAR-3D not only achieves superior performance and generalization capabilities compared to existing methods but also exhibits enhanced scaling capabilities compared to joint distribution modeling approaches (e.g., diffusion transformers).

In this work, we tackle the task of learning 3D human Gaussians from a single image, focusing on recovering detailed appearance and geometry including unobserved regions. We introduce a single-view generalizable Human Gaussian Model (HGM), which employs a novel generate-then-refine pipeline with the guidance from human body prior and diffusion prior. Our approach uses a ControlNet to refine rendered back-view images from coarse predicted human Gaussians, then uses the refined image along with the input image to reconstruct refined human Gaussians. To mitigate the potential generation of unrealistic human poses and shapes, we incorporate human priors from the SMPL-X model as a dual branch, propagating image features from the SMPL-X volume to the image Gaussians using sparse convolution and attention mechanisms. Given that the initial SMPL-X estimation might be inaccurate, we gradually refine it with our HGM model. We validate our approach on several publicly available datasets. Our method surpasses previous methods in both novel view synthesis and surface reconstruction. Our approach also exhibits strong generalization for cross-dataset evaluation and in-the-wild images.

Multi-modality imaging is widely used in clinical practice and biomedical research to gain a comprehensive understanding of an imaging subject. Currently, multi-modality imaging is accomplished by post hoc fusion of independently reconstructed images under the guidance of mutual information or spatially registered hardware, which limits the accuracy and utility of multi-modality imaging. Here, we investigate a data-driven multi-modality imaging (DMI) strategy for synergetic imaging of CT and MRI. We reveal two distinct types of features in multi-modality imaging, namely intra- and inter-modality features, and present a multi-sensor learning (MSL) framework to utilize the crossover inter-modality features for augmented multi-modality imaging. The MSL imaging approach breaks down the boundaries of traditional imaging modalities and allows for optimal hybridization of CT and MRI, which maximizes the use of sensory data. We showcase the effectiveness of our DMI strategy through synergetic CT-MRI brain imaging. The principle of DMI is quite general and holds enormous potential for various DMI applications across disciplines.

Recent advancements in endoscopy video analysis have relied on the utilization of relatively short video clips extracted from longer videos or millions of individual frames. However, these approaches tend to neglect the domain-specific characteristics of endoscopy data, which is typically presented as a long stream containing valuable semantic spatial and temporal information. To address this limitation, we propose EndoFM-LV, a foundation model developed under a minute-level pre-training framework upon long endoscopy video sequences. To be specific, we propose a novel masked token modeling scheme within a teacher-student framework for self-supervised video pre-training, which is tailored for learning representations from long video sequences. For pre-training, we construct a large-scale long endoscopy video dataset comprising 6,469 long endoscopic video samples, each longer than 1 minute and totaling over 13 million frames. Our EndoFM-LV is evaluated on four types of endoscopy tasks, namely classification, segmentation, detection, and workflow recognition, serving as the backbone or temporal module. Extensive experimental results demonstrate that our framework outperforms previous state-of-the-art video-based and frame-based approaches by a significant margin, surpassing Endo-FM (5.6% F1, 9.3% Dice, 8.4% F1, and 3.3% accuracy for classification, segmentation, detection, and workflow recognition) and EndoSSL (5.0% F1, 8.1% Dice, 9.3% F1 and 3.1% accuracy for classification, segmentation, detection, and workflow recognition).

Whole slide image (WSI) analysis is gaining prominence within the medical imaging field. However, previous methods often fall short of efficiently processing entire WSIs due to their gigapixel size. Inspired by recent developments in state space models, this paper introduces a new Pathology Mamba (PAM) for more accurate and robust WSI analysis. PAM includes three carefully designed components to tackle the challenges of enormous image size, the utilization of local and hierarchical information, and the mismatch between the feature distributions of training and testing during WSI analysis. Specifically, we design a Bi-directional Mamba Encoder to process the extensive patches present in WSIs effectively and efficiently, which can handle large-scale pathological images while achieving high performance and accuracy. To further harness the local information and inherent hierarchical structure of WSI, we introduce a novel Local-aware Scanning module, which employs a local-aware mechanism alongside hierarchical scanning to adeptly capture both the local information and the overarching structure within WSIs. Moreover, to alleviate the patch feature distribution misalignment between training and testing, we propose a Test-time Importance Resampling module to conduct testing patch resampling to ensure consistency of feature distribution between the training and testing phases, and thus enhance model prediction. Extensive evaluation on nine WSI datasets with cancer subtyping and survival prediction tasks demonstrates that PAM outperforms current state-of-the-art methods and also its enhanced capability in modeling discriminative areas within WSIs. The source code is available at https://github.com/HKU-MedAI/PAM.

Animating virtual avatars to make co-speech gestures facilitates various applications in human-machine interaction. The existing methods mainly rely on generative adversarial networks (GANs), which typically suffer from notorious mode collapse and unstable training, thus making it difficult to learn accurate audio-gesture joint distributions. In this work, we propose a novel diffusion-based framework, named Diffusion Co-Speech Gesture (DiffGesture), to effectively capture the cross-modal audio-to-gesture associations and preserve temporal coherence for high-fidelity audio-driven co-speech gesture generation. Specifically, we first establish the diffusion-conditional generation process on clips of skeleton sequences and audio to enable the whole framework. Then, a novel Diffusion Audio-Gesture Transformer is devised to better attend to the information from multiple modalities and model the long-term temporal dependency. Moreover, to eliminate temporal inconsistency, we propose an effective Diffusion Gesture Stabilizer with an annealed noise sampling strategy. Benefiting from the architectural advantages of diffusion models, we further incorporate implicit classifier-free guidance to trade off between diversity and gesture quality. Extensive experiments demonstrate that DiffGesture achieves state-of-the-art performance, which renders coherent gestures with better mode coverage and stronger audio correlations. Code is available at https://github.com/Advocate99/DiffGesture.

Co-occurrent visual patterns suggest that pixel relation modeling facilitates dense prediction tasks, which inspires the development of numerous context modeling paradigms, \emph{e.g.}, multi-scale-driven and similarity-driven context schemes. Despite the impressive results, these existing paradigms often suffer from inadequate or ineffective contextual information aggregation due to reliance on large amounts of predetermined priors. To alleviate the issues, we propose a novel \textbf{I}ntervention-\textbf{D}riven \textbf{R}elation \textbf{Net}work (\textbf{IDRNet}), which leverages a deletion diagnostics procedure to guide the modeling of contextual relations among different pixels. Specifically, we first group pixel-level representations into semantic-level representations with the guidance of pseudo labels and further improve the distinguishability of the grouped representations with a feature enhancement module. Next, a deletion diagnostics procedure is conducted to model relations of these semantic-level representations via perceiving the network outputs and the extracted relations are utilized to guide the semantic-level representations to interact with each other. Finally, the interacted representations are utilized to augment original pixel-level representations for final predictions. Extensive experiments are conducted to validate the effectiveness of IDRNet quantitatively and qualitatively. Notably, our intervention-driven context scheme brings consistent performance improvements to state-of-the-art segmentation frameworks and achieves competitive results on popular benchmark datasets, including ADE20K, COCO-Stuff, PASCAL-Context, LIP, and Cityscapes.

Deploying device-to-device (D2D) communication over underlaying cellular network can significantly enhance the spectrum utilization. However, co-channel interference will occur when D2D pairs share the same radio resource with cellular users. To mitigate the interference within a reasonable range, a machine learning based resource reuse scheme for D2D and cellular users is proposed in this paper. Specifically, we formulate an optimization problem to maximize the total throughput of D2D pairs and cellular users by optimally allocating subcarrier and power within the limits of the interference threshold. Since the formulated problem is a mixed integer non-linear programming problem, we solve it in two steps. First, we assign the orthogonal subcarriers to different cellular users to maximize the total throughput of all cellular users. Then, D2D pairs are allowed to reuse different subcarriers to further enhance the throughput without affecting the performance of cellular users. The second step is still NP-hard and therefore we propose a low-complexity algorithm based on the pointer network, a specific neural network structure proposed recently. Results reveal that, with remarkably reduced complexity, the proposed scheme outperforms the conventional resource allocation algorithms.