ECG-imaging has been receiving increasing clinical and commercialization interest as a non-invasive technology for computing cardiac electrical activity and facilitating clinical management of heart rhythm disorders. Despite its potential, the standard ECG-imaging pipeline requires thorax imaging for constructing patient-specific heart-thorax geometry - being outside standard-of-care clinical workflow, this component constitutes a major barrier to the clinical adoption of ECG-imaging. The advent of 3D cameras into ECG-imaging workflow to replace thorax imaging has shown promise, although existing works largely neglect the registration between camera-derived thorax models with an individual's heart geometry. In this work, we address this gap with a novel system that generates patient-specific torso geometry using a 3D camera, registers the torso to heart geometry obtained from pre-existing cardiac scans, and optimally deforms the torso to the skin surface of the patient. We evaluated the presented camera-based ECG-imaging system on five patients undergoing ablation of scar-related ventricular tachycardia, where we evaluate both the accuracy of the surface electrode localization and the ECG-imaging solutions in comparison to those obtained from computed tomography based thorax imaging. We further evaluate the use of the presented camera-based patient-specific heart-thorax model versus a generic heart-thorax model, highlighting the importance of the registration between the camera-based thorax models with cardiac scans.

Predicting low-energy molecular conformations given a molecular graph is an important but challenging task in computational drug discovery. Existing state- of-the-art approaches either resort to large scale transformer-based models that diffuse over conformer fields, or use computationally expensive methods to gen- erate initial structures and diffuse over torsion angles. In this work, we introduce Equivariant Transformer Flow (ET-Flow). We showcase that a well-designed flow matching approach with equivariance and harmonic prior alleviates the need for complex internal geometry calculations and large architectures, contrary to the prevailing methods in the field. Our approach results in a straightforward and scalable method that directly operates on all-atom coordinates with minimal assumptions. With the advantages of equivariance and flow matching, ET-Flow significantly increases the precision and physical validity of the generated con- formers, while being a lighter model and faster at inference. Code is available https://github.com/shenoynikhil/ETFlow.