We present PathoOpenGait, a cloud-based platform for comprehensive gait analysis. Gait assessment is crucial in neurodegenerative diseases such as Parkinson's and multiple system atrophy, yet current techniques are neither affordable nor efficient. PathoOpenGait utilizes 2D and 3D data from a binocular 3D camera for monitoring and analyzing gait parameters. Our algorithms, including a semi-supervised learning-boosted neural network model for turn time estimation and deterministic algorithms to estimate gait parameters, were rigorously validated on annotated gait records, demonstrating high precision and consistency. We further demonstrate PathoOpenGait's applicability in clinical settings by analyzing gait trials from Parkinson's patients and healthy controls. PathoOpenGait is the first open-source, cloud-based system for gait analysis, providing a user-friendly tool for continuous patient care and monitoring. It offers a cost-effective and accessible solution for both clinicians and patients, revolutionizing the field of gait assessment. PathoOpenGait is available at https://pathoopengait.cmdm.tw.

SUMMARY: Drug discovery targeting G protein-coupled receptors (GPCRs), the largest known class of therapeutic targets, is challenging. To facilitate the rapid discovery and development of GPCR drugs, we built a system, PanGPCR, to predict multiple potential GPCR targets and their expression locations in the tissues, side effects and possible repurposing of GPCR drugs. With PanGPCR, the compound of interest is docked to a library of 36 experimentally determined crystal structures comprising of 46 docking sites for human GPCRs, and a ranked list is generated from the docking studies to assess all GPCRs and their binding affinities. Users can determine a given compound's GPCR targets and its repurposing potential accordingly. Moreover, potential side effects collected from the SIDER (Side-Effect Resource) database and mapped to 45 tissues and organs are provided by linking predicted off-targets and their expressed sequence tag profiles. With PanGPCR, multiple targets, repurposing potential and side effects can be determined by simply uploading a small ligand. AVAILABILITY AND IMPLEMENTATION: PanGPCR is freely accessible at https://gpcrpanel.cmdm.tw/index.html. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.