Abstract State-of-the-art program-analysis techniques are not yet able to effectively verify safety properties of heterogeneous systems, that is, systems with components implemented using diverse technologies. This shortcoming is pinpointed by programs invoking neural networks despite their acclaimed role as innovation drivers across many application areas. In this paper, we embark on the verification of system-level properties for systems characterized by interaction between programs and neural networks. Our technique provides a tight two-way integration of a program and a neural-network analysis and is formalized in a general framework based on abstract interpretation. We evaluate its effectiveness on 26 variants of a widely used, restricted autonomous-driving benchmark.